期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
静脉麻醉药物群体药代学、药效学研究近况 被引量:1
1
作者 张兴安 李复金 《国外医学(麻醉学与复苏分册)》 2004年第1期36-38,共3页
群体药代学与药效学研究即药代动力学和药效动力学的群体分析法,它定量地考察患者群体中药物浓度的决定因素,常采用的统计学方法为非线性混合效应模型。对几种常用的静脉麻醉药物药动学和药效学进展一并综述。
关键词 静脉麻醉 群体药代学 群体效学 靶控输注 硫喷妥钠 安定
下载PDF
致患识消失的药物效应室浓度可指导实施个体化的靶控输注
2
作者 董佳(编译) 《麻醉与监护论坛》 2005年第5期327-327,共1页
近年来.靶控输注技术以其精准、可控性强等优点而备受麻醉学界的推崇。但由于这项技术是建立在群体药代学特性之上.所以一旦忽略了个体化用药的原则.它的技术优势往往很难得到发挥。甚至还容易引发循环和呼吸抑制等一系列不良反应。... 近年来.靶控输注技术以其精准、可控性强等优点而备受麻醉学界的推崇。但由于这项技术是建立在群体药代学特性之上.所以一旦忽略了个体化用药的原则.它的技术优势往往很难得到发挥。甚至还容易引发循环和呼吸抑制等一系列不良反应。目前.人们对临床上可供指导实施靶控输注的最佳方法尚未达成一致.新近。Iwakiri等(Iwokkiri H,Nishlhara N,Nagata O,et al. 展开更多
关键词 个体化用 靶控输注 效应室浓度 群体药代学 不良反应 呼吸抑制 麻醉学 可控性
下载PDF
Population pharmacokinetics of paeoniflorin in guanxin Ⅱ prescription 被引量:3
3
作者 陈文倩 胡渝慧 +4 位作者 张彦青 张关敏 李良 杨维宁 卢炜 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第1期55-63,共9页
To evaluate the effect of components in Guanxin Ⅱ prescription on the pharmacokinetic profiles of paeoniflorin. Plasma concentration of Paeoniflorin in rats after intravenous injection of Paronia Pall Extract (PPE)... To evaluate the effect of components in Guanxin Ⅱ prescription on the pharmacokinetic profiles of paeoniflorin. Plasma concentration of Paeoniflorin in rats after intravenous injection of Paronia Pall Extract (PPE) and oral administration of PPE and three types of decoctions in Guanxin Ⅱ prescription, respectively, were determined by HPLC analyses. NONMEM (nonlinear mixed-effect modeling) method was used to analyze full set of pharmacokinetic data directly. A two-compartment model with first-order degradation in absorption compartment was employed for the data analysis. The mean of population parameters, CL1, V1, CL2, V2, Ka0, and Kal, were measured to be 0.509 L/h, 0.104 L, 0.113 L/h, 0.123 L, 0.135/h, and 0.0135/h, respectively. Inter-individual variabilities were estimated and dose formulation (DF) was identified as a significant covariate of Ka 1, Ka0, and V1. It is concluded that the pharmacokinetic behaviors of paeoniflorin in rats can alter with different dose formulations. 展开更多
关键词 PAEONIFLORIN Population pharmacokinetics Traditional Chinese Medicine Guanxin Compound formulae
下载PDF
Bayesian analysis for mixed-effects model defined by stochastic differential equations
4
作者 言方荣 张萍 +1 位作者 陆涛 林金官 《Journal of Southeast University(English Edition)》 EI CAS 2014年第1期122-127,共6页
The nonlinear mixed-effects model with stochastic differential equations (SDEs) is used to model the population pharmacokinetic (PPK) data that are extended from ordinary differential equations (ODEs) by adding ... The nonlinear mixed-effects model with stochastic differential equations (SDEs) is used to model the population pharmacokinetic (PPK) data that are extended from ordinary differential equations (ODEs) by adding a stochastic term to the state equation. Compared with the ODEs, the SDEs can model correlated residuals which are ubiquitous in actual pharmacokinetic problems. The Bayesian estimation is provided for nonlinear mixed-effects models based on stochastic differential equations. Combining the Gibbs and the Metropolis-Hastings algorithms, the population and individual parameter values are given through the parameter posterior predictive distributions. The analysis and simulation results show that the performance of the Bayesian estimation for mixed-effects SDEs model and analysis of population pharmacokinetic data is reliable. The results suggest that the proposed method is feasible for population pharmacokinetic data. 展开更多
关键词 population pharmacokinetics mixed-effectsmodels stochastic differential equations Bayesian analysis
下载PDF
Population pharmacokinetics of risperidone based on meta-analysis and its application in therapeutic drug monitoring of Chinese schizophrenic patients 被引量:2
5
作者 季双敏 尚德为 +6 位作者 王曦培 李安宁 任宇鹏 李良 周田彦 王传跃 卢炜 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第2期75-82,共8页
Population pharmacokinetic meta-analysis method was used in order to obtain the pharmacokinetic characteristics of risperidone and its active metabolite. Eighteen studies were selected from published papers from 1995 ... Population pharmacokinetic meta-analysis method was used in order to obtain the pharmacokinetic characteristics of risperidone and its active metabolite. Eighteen studies were selected from published papers from 1995 to 2011. A model consisted of two compartments for parent drug and one compartment for its active metabolite combined with a flexible absorption process was developed based on the meta-dataset. The population-predicted apparent clearance for risperidone and 9-hydroxyrisperidone, the active metabolite was 7.66 L/h and 7.38 L/h, and the apparent volume of distribution in the central compartment was 70.6 L and 117 L, respectively. The final model was evaluated by visual predictive check(VPC) based on 1000 times model simulation. This model was adequately used to predict clinical therapeutic drug monitoring(TDM) data from 42 Chinese inpatients. Bias(mean prediction errors, MPE) and precision(root mean squared prediction errors, RMSE) were calculated to statistically analysis the population prediction error. It was demonstrated that the model developed from the meta-dataset was reliable and can be used to facilitate the individualized treatment for a target population. 展开更多
关键词 META-ANALYSIS Population pharmacokinetics RISPERIDONE 9-HYDROXYRISPERIDONE
原文传递
Population pharmacokinetic of losartan and its active metabolite E-3174 in five different ethnic populations of China
6
作者 杨璐 孙路路 +4 位作者 郭涛 夏东亚 王曦培 李新刚 卢炜 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第8期548-557,共10页
The aim of this study was to develop a combined population pharmacokinetic (PPK) model for losartan and its active metabolite E-3174 in five Chinese ethnicities for individualized drug therapy in clinical practice. ... The aim of this study was to develop a combined population pharmacokinetic (PPK) model for losartan and its active metabolite E-3174 in five Chinese ethnicities for individualized drug therapy in clinical practice. HPLC method was used to determine the blood levels of losartan and E-3174 simultaneously. One-, two- and three-compartment models were fitted to plasma concentration time data of 50 Chinese healthy subjects (including Han, Mongolian, Korean, Hui and Uigur) using nonlinear mixed-effect modeling (NONMEM). From the basic model of losartan, the effects of demography and biochemical covariates were investigated, which were added one by one by the forward inclusion and backward elimination. The final models of losartan and E-3174 were connected by first order or transit compartment model. Pharmacokinetic parameters of losartan and its active metabolite E-3174 were assessed simultaneously in one integrated model with the plausible covariates on the key pharmacokinetic parameters of E-3174. Nonparametric bootstrap was used for the model stability validation. The data of losartan were best described using a two-compartment model with linear elimination. The time to reach Cmax of losartan and E-3174 were obtained to be 0.9 and 3.8 h, respectively. Two transit compartments were chosen with adequate fit of the delayed Tmax of E-3174. The population estimates for transformation of losartan to E-3174 was about 73.9%. Ethnicity factor showed significant influence on the non-metabolizing E-3174 clearance CL10, the peripheral compartment clearance CL2 and the central compartment volume Vj of losartan and also has a significant effect on the transit rate (Kt). A total of 925 out of 1000 iterations succeeded in minimization. The PPK models were steady and reliable. Ethnicity factor showed significant influence on both losartan clearance and the transition from losartan to E-3174, no covariate influencing the PK parameters of E-3174 was identified. 展开更多
关键词 LOSARTAN E-3174 Population pharmacokinetics NONMEM ETHNICITY
原文传递
A validated HPLC method for the determination of donepezil in human plasma after derivatization with 9-fluorenylmethyl chloroformate 被引量:2
7
作者 Reza Ahmadkhaniha Abdolrahman Nazari +1 位作者 Mohsen Amini Effat Souri 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第2期118-123,共6页
A new HPLC method has been developed for determining donepezil in human plasma. To find the optimum conditions, a derivatization reaction was performed in different media, and the reaction product was identified by NM... A new HPLC method has been developed for determining donepezil in human plasma. To find the optimum conditions, a derivatization reaction was performed in different media, and the reaction product was identified by NMR and GC-MS after a semi-preparative HPLC separation. Under optimized conditions, donepezil was derivatized by 9-fluorenylmethyl chloroformate in chloroform and carbonate buffer at pH 9.5 in the presence of NaI after solid-phase extraction from a plasma sample. The reaction product was quantified on a reversed-phase TRACER EXCEL ODS-A, 5 μm column using a mixture of acetonitrile–10 mM acetate buffer(pH 6.0)–THF(60:35:5, v/v/v) as the mobile phase with fluorescence detection at 264 nm(ex) and 313 nm(em). Fluoxetine was used as the internal standard. The total run-time of the analysis was about 10 min, and a clean chromatogram was obtained. The developed method was linear over the range of 1–100 ng/mL in 500 μL of plasma samples(r2>0.998). The intra-day and inter-day precision values were in the range of 2.6%–11.6%. The limit of quantification was 1 ng/mL. 展开更多
关键词 9-Fluorenylmethyl chloroformate DERIVATIZATION HPLC
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部