群构建筑的可进入性空间设计探索与实践——以杭州湾信息港六期建筑设计为例

以萧山杭州湾信息港建筑设计为例,从城市设计的视角,通过可进入性解决空间的“公共”和“私有”之间的矛盾,从群构建筑空间的整体性、层次性和延续性三个层面提出了设计对策,可为城市建筑中可进入性空间的相似设计提供一定的参考与借鉴。

Synthesis, Growth, and Characterization of a New Thiourea and Bismuth Chloride Complex with Excellent Nonlinear Optical Properties

Crystals of a new organometallic nonlinear optical （NLO） compound, di-ta-chloro-bis[chlorotri（thiourea）bismuth（Ⅲ）]- pentachloro（thiourea）bismuth-ate（Ⅲ） （DCBPB）, have been successfully grown from formic acid aqueous solutions of thio-urea and bismuth chloride by a slow evaporation technique. The crystal structure and atomic composition of DCBPB have been confirmed by single crystal X-ray diffraction （SCXRD）, Fourier transform infrared spectra, and elemental analysis. The SCXRD results proved that DCBPB crystallizes in triclinic space group P1 with unit cell dimensions of a = 7.0606（2） A, b = 8.8106（4） A, c = 16.3247（8） A, a = 99.242（4）°, fl = 95.309（3）°, ）/= 105.856（3）°, and Z= 2. DCBPB crystal exhibits excel-lent transmittance from 500 to 2500 nm and green fluorescence with maximum emission at 508 nm. The thermogravimetric-differential scanning calorimetry （TG-DSC） analysis indicates that a solid-phase reaction took place at 170.1 ℃, whereas the decomposition temperature of the crystal material was 189℃. The NLO property obtained by the Kurtz powder test showed that the second harmonic generation efficiency of DCBPB crystal is two-seventh of KDP crystal.

LincRNA-1614 coordinates Sox2/PRC2-mediated repression of developmental genes in pluripotency maintenance

Large-intergenic noncoding RNAs （lincRNAs） cooperate with core transcription factors to coordinate the pluripotency network of embryonic stem cells. The mechanisms by which lincRNAs affect chromatin structure and gene transcription remain mostly unknown. Here, we identified that a UncRNA （linc1614）, occupied by pluripotency factors at its promoter, was indispensable for both maintenance and acquisition of pluripotency. Linc1614 sewed as a specific partner of core factor Sox2 in maintaining pluripotency, primarily by mediating the function of Sox2 in the repression of developmental genes. Moreover, Ezh2, an essential subunit of polycomb repressive complex 2 （PRC2）, physically interacted with linc1614 and contributed to lincRNA-mediated transcriptional silencing. Thus, we propose that the interplay of linc1614 with Sox2 implicates this lincRNA as a recruitment platform that mediates transcriptional silencing by guiding the PRC2 complex to the loci of developmental genes.

Lanthanide complexes mediated coordinative chain transfer polymerization of conjugated dienes

Tremendous advances has been witnessed in the past few years in the lanthanide complexes mediated coordinative chain transfer polymerization(CCTP) of conjugated dienes. CCTP features catalyst economy, well-controlling over both microstructure and architecture of the resulting polymers, and accessibility for novel(co)polymers. This review highlights the recent progresses made in the field of CCTP of dienes. After a brief introduction, the body of this review is divided into three parts:(1) principle of CCTP;(2) coordinative chain transfer homopolymerization of dienes;(3) coordinative chain transfer copolymerization of dienes.At the end, we present some challenges remaining in this area and our personal opinion regarding where this field should continue to develop. CCTP represents a novel strategy to prepare polydiene synthetic rubbers with controlled high molecular weight and narrow molecular weight distribution, which has reached the practical industrial application level, demonstrating a great potential in industrialization.

Application of computer-assisted surgery techniques in the management of zygomatic complex fractures

Patients suffering from zygomatic complex fractures always present facial deformity and dyslunctions, and thereafter develop psychological and physiological problems. It is really hard to get an ideal prog- nosis for the zygomatic complex fractures because of the complicated anatomical structures. Computer- assisted surgery techniques, as the new emerging auxiliary methods, can optimize the surgical protocol, predict operation outcomes, and improve the accuracy and quality of the operation. Meanwhile the postoperative complications can be reduced effectively. This review aims to provide a comprehensive overview of the application of computer-assisted surgery techniques in the management of zygomatic complex fractures.

Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6

The Clustered Regularly Interspaced Short _Palindromic Repeats （CRISPR）-CRISPR-associated （Cas） system is an adaptive immune system in bacteria and archaea that resists exogenous invasion through nucleic acid-mediated cleavage. In the type III-A system, the Csm complex contains five effectors and a CRISPR RNA, which edits both single stranded RNA and double stranded DNA. It has recently been demonstrated that cyclic oligoadenylates （cOAs）, which are synthesized by the Csm complex, act as second messengers that bind and activate Csm6. Here, we report the crystal structures of Staphylococcus epiderrnidis Csm3 （SeCsm3） and an N-terminally truncated Csm6 （SeCsm6AN） at 2.26 and 2.0 A, respectively. The structure of SeCsm3 highly resembled previously reported Csm3 structures from other species; however, it provided novel observations allowing further enzyme characterization. The homodimeric SeCsm6AN folds into a compact structure. The dimerization of the HEPN domain leads to the formation of the ribonuclease active site, which is consistent with the reported Csm6 structures. Altogether, our studies provide a struc- tural view of the ribonuclease activity mediated by Csm3 and Csm6 of the type III-A CRISPR-Cas system.

Controlling the solid-state luminescence of gold(I) N-heterocyclic carbene complexes through changes in the structure of molecular aggregates

Thermally stable, solid-state luminescent organic materials are highly desired for the development of practical applications.Herein we synthesized new gold(I) complexes with N-heterocyclic carbene ligands, which have the ability to form strong metalorganic bond. Consequently, their thermochemical stability is enhanced at temperatures around 300 °C. Precise design of the molecular structure of the ligands, with a focus on ensuring low steric hindrance around Au atoms in order to limit disturbances to Au/Au interactions, provided a complex with a densely packed crystal with a shorter intermolecular Au–Au distance(3.17 ?)than the typical distance. In the solid state, this complex exhibited strong aurophilic interactions, which generated intense phosphorescence even in air at room temperature(quantum yield=16%) in spite of absence of any phosphorescence in solution.This behavior is characteristic for solid-state luminescence referred to as aggregation-controlled emission. Furthermore, the gold(I) complex displays capacity for mechano-and vapo-chromism—that is, the ability to change color reversibly in response to the application of external stimuli. We believe that the proposed design framework, which involves controlling thermal stability and luminescence property separately, provides a new opportunity for the development of practical applications using solid-state luminescent organic molecules.

Highly efficient green organic light-emitting devices based on terbium complex by employing hole block material as host

In this work,efficient green electroluminescent（EL）devices with simplified device structure were prepared by doping trivalent terbium complex Tb（PMIP）3into hole block material Tm Py PB.The high triplet energy of Tm Py PB helps to confine excitons within light-emitting layer,while the electron transport characteristic of Tm Py PB facilitates the balance of carriers on Tb（PMIP）a3molecules.By optimizing the doping concentration of Tb（PMIP）a3and the thickness of each functional layer,highly efficient green EL device with the structure of ITO/Mo Oa3（3 nm）/TAPC（50 nm）/Tb（PMIP）a3（30 wt%）：Tm Py PB（25 nm）/Tm Py PB（60 nm）/Li F（1 nm）/Al（100 nm）displayed pure Tb^3＋ characteristic emission with maximum current efficiency,power efficiency and brightness up to 47.24 cd/A（external quantum efficiency（EQE）of 14.4%）,43.63 lm/W and 1694 cd/m^2,respectively.At certain brightness of 100 cd/m^2,the device still maintained a current efficiency of 19.96 cd/A（EQE=6.1%）.Such a device design strategy helps to improve the EL performances of Tb（PMIP）a3and to simplify device fabrication processes,thus reduce the fabrication cost.