We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis （AIH） and systemic lupus erythematosus （SLE）. The patient presented with jaundice, hepatosplenomegaly, malaise, polya...We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis （AIH） and systemic lupus erythematosus （SLE）. The patient presented with jaundice, hepatosplenomegaly, malaise, polyarthralgia, arthritis and butterfly rash on the face. Laboratory tests revealed severe liver dysfunction, Coombs positive hemolytic anemia and a positive ANA/ anti-dsDNA test. Renal biopsy showed class IIA kidney disease, while liver biopsy showed chronic hepatitis with severe inflammatory activity. The patient satisfied the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with high dose treatment with corticosteroids and azathioprine, however, remission of the liver disease could not be achieved. Repeat biopsy of the liver after three years of therapy revealed ongoing chronic hepatitis with high level of inflammatory activity. The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome.展开更多
The Lithuania 2011 Childhood is not just a product of human development but also a product of society＇s educational and spiritual culture development. This paper aims to disclose how nowadays the family helps the chi...The Lithuania 2011 Childhood is not just a product of human development but also a product of society＇s educational and spiritual culture development. This paper aims to disclose how nowadays the family helps the child to develop adaptation instruments which would help to adapt to the society in a micromacro environment, to show what helps the child to become a member of a social group, of the society, what adaptation problems arise during the childhood. Problems of school adaptation of the first-formers have not been properly assessed and analysed so far, though they foresee the future. No proper attention has been paid to the development of the harmonious personality during the pre-school period and to the correction of their adaptation during the firstschool year. The paper deals with the child＇s experiences of the pre-school period as the factor influencing school adaptation in the first form. Variety and quality of children＇s experiences are directly related and most of all depend on the family of the spiritual institution, so its impact is the strongest in terms of the development of the child＇s personality. The goal is to disclose the importance of selfdevelopment in childhood, which determines future success. The object is selfdevelopment during childhood today in the Lithuania. Methods of investigation are： the analysis of pedagogical, psychological, philosophical literature; the analysis of empiri.cal researches and statistic data; and the method of observation. The hypothesis is： The cause of the firstformers＇ school adaptation difficulties incompletely realised adaptation potential during the preschool period.展开更多
We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE we...We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.展开更多
Autism spectrum disorder(ASD) is diagnosed on the basis of core impairments in pragmatic language skills, which are found across all ages and subtypes. In contrast, there is significant heterogeneity in language pheno...Autism spectrum disorder(ASD) is diagnosed on the basis of core impairments in pragmatic language skills, which are found across all ages and subtypes. In contrast, there is significant heterogeneity in language phenotypes, ranging from nonverbal to superior linguistic abilities, as defined on standardized tests of vocabulary and grammatical knowledge. The majority of children are verbal but impaired in language, relative to age-matched peers. One hypothesis is that this subgroup has ASD and co-morbid specific language impairment(SLI). An experiment was conducted comparing children with ASD to children with SLI and typically developing controls on aspects of language processing that have been shown to be impaired in children with SLI: repetition of nonsense words. Patterns of performance among the children with ASD and language impairment were similar to those with SLI, and contrasted with the children with ASD and no language impairment and typical controls, providing further evidence for the hypothesis that a subgroup of children with ASD has co-morbid SLI. The findings are discussed in the context of brain imaging studies that have explored the neural bases of language impairment in ASD and SLI, and overlap in the genes associated with elevated risk for these disorders.展开更多
The paper examines how the British woman writer Angela Carter rewrites Charles Perrault＇s household fairy tale--＂Little Red Riding Hood＂ in her short story--＂The Company of Wolves.＂ This paper attempts to analyze...The paper examines how the British woman writer Angela Carter rewrites Charles Perrault＇s household fairy tale--＂Little Red Riding Hood＂ in her short story--＂The Company of Wolves.＂ This paper attempts to analyze the two distinctive narrative strategies--re-characterization and second-person narration, skillfully deployed by Carter in order to rewrite Perrault＇ s classic tale into a feminist story. In Carter＇s version, Little Red Riding Hood is represented as a witty new woman who embraces her own sexuality and regards herself as a subject rather than an object. Through the transposition between reader and character, Carter＇s tale produces a new subject position for readers, particularly for young female readers.展开更多
文摘We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis （AIH） and systemic lupus erythematosus （SLE）. The patient presented with jaundice, hepatosplenomegaly, malaise, polyarthralgia, arthritis and butterfly rash on the face. Laboratory tests revealed severe liver dysfunction, Coombs positive hemolytic anemia and a positive ANA/ anti-dsDNA test. Renal biopsy showed class IIA kidney disease, while liver biopsy showed chronic hepatitis with severe inflammatory activity. The patient satisfied the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with high dose treatment with corticosteroids and azathioprine, however, remission of the liver disease could not be achieved. Repeat biopsy of the liver after three years of therapy revealed ongoing chronic hepatitis with high level of inflammatory activity. The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome.
文摘The Lithuania 2011 Childhood is not just a product of human development but also a product of society＇s educational and spiritual culture development. This paper aims to disclose how nowadays the family helps the child to develop adaptation instruments which would help to adapt to the society in a micromacro environment, to show what helps the child to become a member of a social group, of the society, what adaptation problems arise during the childhood. Problems of school adaptation of the first-formers have not been properly assessed and analysed so far, though they foresee the future. No proper attention has been paid to the development of the harmonious personality during the pre-school period and to the correction of their adaptation during the firstschool year. The paper deals with the child＇s experiences of the pre-school period as the factor influencing school adaptation in the first form. Variety and quality of children＇s experiences are directly related and most of all depend on the family of the spiritual institution, so its impact is the strongest in terms of the development of the child＇s personality. The goal is to disclose the importance of selfdevelopment in childhood, which determines future success. The object is selfdevelopment during childhood today in the Lithuania. Methods of investigation are： the analysis of pedagogical, psychological, philosophical literature; the analysis of empiri.cal researches and statistic data; and the method of observation. The hypothesis is： The cause of the firstformers＇ school adaptation difficulties incompletely realised adaptation potential during the preschool period.
文摘We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.
基金supported by the National Institutes of Health(Grant Nos.U19 DC03610,RO1 DC 10290,and M01 RR00533)
文摘Autism spectrum disorder(ASD) is diagnosed on the basis of core impairments in pragmatic language skills, which are found across all ages and subtypes. In contrast, there is significant heterogeneity in language phenotypes, ranging from nonverbal to superior linguistic abilities, as defined on standardized tests of vocabulary and grammatical knowledge. The majority of children are verbal but impaired in language, relative to age-matched peers. One hypothesis is that this subgroup has ASD and co-morbid specific language impairment(SLI). An experiment was conducted comparing children with ASD to children with SLI and typically developing controls on aspects of language processing that have been shown to be impaired in children with SLI: repetition of nonsense words. Patterns of performance among the children with ASD and language impairment were similar to those with SLI, and contrasted with the children with ASD and no language impairment and typical controls, providing further evidence for the hypothesis that a subgroup of children with ASD has co-morbid SLI. The findings are discussed in the context of brain imaging studies that have explored the neural bases of language impairment in ASD and SLI, and overlap in the genes associated with elevated risk for these disorders.
文摘The paper examines how the British woman writer Angela Carter rewrites Charles Perrault＇s household fairy tale--＂Little Red Riding Hood＂ in her short story--＂The Company of Wolves.＂ This paper attempts to analyze the two distinctive narrative strategies--re-characterization and second-person narration, skillfully deployed by Carter in order to rewrite Perrault＇ s classic tale into a feminist story. In Carter＇s version, Little Red Riding Hood is represented as a witty new woman who embraces her own sexuality and regards herself as a subject rather than an object. Through the transposition between reader and character, Carter＇s tale produces a new subject position for readers, particularly for young female readers.
