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翻译组学相关技术的应用研究进展
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作者 罗锦堂 张晓娟 +5 位作者 奚英杰 张林林 郭益文 丁向彬 郭宏 李新 《天津农业科学》 CAS 2020年第7期12-16,共5页
随着高通量测序技术和质谱技术的兴起与发展,全基因组学、转录组学、蛋白质组学等多种组学技术被广泛的应用于生物研究领域用以深入探究细胞或组织中基因和蛋白的表达模式及调控机理。转录组测序和蛋白质谱技术是当前研究基因和蛋白功... 随着高通量测序技术和质谱技术的兴起与发展,全基因组学、转录组学、蛋白质组学等多种组学技术被广泛的应用于生物研究领域用以深入探究细胞或组织中基因和蛋白的表达模式及调控机理。转录组测序和蛋白质谱技术是当前研究基因和蛋白功能的主要技术手段,但因从mRNA到蛋白质的翻译过程受到转录及转录后水平、翻译及翻译后水平等多种不同水平的调控影响。转录组结果和蛋白组结果二者间相关性较低,匹配度较差,无法对基因和蛋白的功能及调控途径进行最为有效的机制分析,而翻译组学技术作为蛋白质组学与转录组学之间的“桥梁”,可以提供参与核糖体翻译过程的RNA信息,显著增加了RNA和蛋白质之间的相关性,揭示了RNA到蛋白质的中间进程,为阐释转录本丰度与蛋白质丰度之间差异原因,分析遗传信息从核苷酸到氨基酸的过程途径提供了技术支撑。本文介绍了目前翻译组学中最常用的四种技术方法的原理、应用以及优缺点,以期为将来利用翻译组学技术手段开展相关研究提供参考。 展开更多
关键词 转录 蛋白质 核糖体新生肽链复合物 MRNA 翻译组学
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The Current Situation and Strategy of College English Translation Teaching
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作者 CHEN Meng-jie SHI Xi-chun 《Sino-US English Teaching》 2015年第12期979-983,共5页
College English translation teaching is an important part of college English teaching. It is the principal way to train translators. However, there are too many problems in the process of college English translation t... College English translation teaching is an important part of college English teaching. It is the principal way to train translators. However, there are too many problems in the process of college English translation teaching and it is really out-dated. Therefore, it is a must to improve college English translation teaching, complete the teaching contents, improve the curriculum provision, explore positive teaching modes, intensify the training of the teachers and enhance the students translation skills, so that the colleges could provide highly-qualified translators for the society 展开更多
关键词 college English translation teaching teaching mode
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The Value Relevance of Foreign Currency Translation Adjustments (FCTAs) in the Italian Stock Exchange
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作者 Olga Ferraro Stefania Veltri 《Journal of Modern Accounting and Auditing》 2012年第10期1523-1534,共12页
The main aim of this paper is to test whether the foreign currency translation adjustments (FCTAs), the largest components of other comprehensive income (OCI) for most firms, are incrementally value-relevant for i... The main aim of this paper is to test whether the foreign currency translation adjustments (FCTAs), the largest components of other comprehensive income (OCI) for most firms, are incrementally value-relevant for investors with respect to the net income (NI). Previous archival research on the value relevance of FCTAs has documented a weak or non-existent link between FCTAs and firm valuation (Pinto, 2005). The hypothesized reasons could reside in the econometric method employed, in the use of as-if numbers, and in the missing consideration of the differential effect that exchange rate changes have on firms of varying levels of capital intensiveness. This study adds to the existing literature by empirically testing the value relevance of as-reported FCTAs numbers in the earnings and book value model the Ohlson-like interacted model through panel data techniques. The main finding of this study is that as-reported FCTAs are significantly and incrementally value-relevant, when their parameter estimates are allowed to vary in the cross-section. 展开更多
关键词 value relevance foreign currency translation adjustments (FCTAs) other comprehensive income (OCI) Italy listed groups as-reported data
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Current advances in the application of proteomics in apoptosis research 被引量:7
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作者 WANG LiShun & CHEN GuoQiang Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China E-Institutes of Shanghai Municipal Education Commission Chemical Biology Division,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China 《Science China(Life Sciences)》 SCIE CAS 2011年第3期209-219,共11页
Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms.Dysregulation of apoptosis has been implicated in a ... Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms.Dysregulation of apoptosis has been implicated in a number of diseases,including cancer and autoimmune disease.Thus,the investigation of apoptotic regulation has evoked considerable interest.Many apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic analysis.Recently,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the field.This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future. 展开更多
关键词 apoptosis PROTEOMICS small compound ONCOGENE tumor suppressor
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