蛋白质合成是一个复杂的过程。在特定情况下,翻译过程中会发生异常核糖体停滞导致无法有效回收核糖体及翻译的元件,从而影响细胞内正常的转录效率。同时,异常翻译的新生多肽通过积累聚集而扰乱蛋白质稳态环境,进而导致疾病的发生。核糖...蛋白质合成是一个复杂的过程。在特定情况下,翻译过程中会发生异常核糖体停滞导致无法有效回收核糖体及翻译的元件,从而影响细胞内正常的转录效率。同时,异常翻译的新生多肽通过积累聚集而扰乱蛋白质稳态环境,进而导致疾病的发生。核糖体翻译质量控制(ribosome associated protein quality control pathway, RQC)为真核细胞核糖体回收、降解错误的新生多肽提供一条拯救途径。最新研究表明,线粒体表面也存在RQC调控,称为线粒体RQC(mitochondrial ribosome associated protein quality control, mitoRQC)。线粒体是真核细胞内参与能量生成和物质代谢的重要细胞器。线粒体中超过98%蛋白质是由核基因编码的,在细胞质中合成后运输到线粒体内,这些蛋白质可能会受到mitoRQC的调控。mitoRQC与线粒体内部调控机制共同维持线粒体的稳定性。阐明线粒体蛋白质翻译的调控机制对研究人类线粒体疾病等方面具有重要意义。本文将重点讨论RQC系统和mitoRQC系统的功能及与疾病的相关性。展开更多
The present work shows the results of a pilot methodology, designed after a series of observations and documented from 2006, on the process of acquisition of Translation Competence （TC） of students of translation. T...The present work shows the results of a pilot methodology, designed after a series of observations and documented from 2006, on the process of acquisition of Translation Competence （TC） of students of translation. This method of analysis, appointed Previous Protocol to Translation or PPT, emerged as an option in search of teaching strategies of translation. This PPT has provided data not only on how novice translators acquire the translation competence, but it has been uncovered some independent variables that directly affect their development. There has been, in the four semesters analyzed in this work, a clear pattern that shows that an appropriate quality control to translate （and to carry out punctual terminology management） determines a better or worse quality of the final product （translations）; therefore, this reflects in a better translation competence in the novice students.展开更多
文摘蛋白质合成是一个复杂的过程。在特定情况下,翻译过程中会发生异常核糖体停滞导致无法有效回收核糖体及翻译的元件,从而影响细胞内正常的转录效率。同时,异常翻译的新生多肽通过积累聚集而扰乱蛋白质稳态环境,进而导致疾病的发生。核糖体翻译质量控制(ribosome associated protein quality control pathway, RQC)为真核细胞核糖体回收、降解错误的新生多肽提供一条拯救途径。最新研究表明,线粒体表面也存在RQC调控,称为线粒体RQC(mitochondrial ribosome associated protein quality control, mitoRQC)。线粒体是真核细胞内参与能量生成和物质代谢的重要细胞器。线粒体中超过98%蛋白质是由核基因编码的,在细胞质中合成后运输到线粒体内,这些蛋白质可能会受到mitoRQC的调控。mitoRQC与线粒体内部调控机制共同维持线粒体的稳定性。阐明线粒体蛋白质翻译的调控机制对研究人类线粒体疾病等方面具有重要意义。本文将重点讨论RQC系统和mitoRQC系统的功能及与疾病的相关性。
文摘The present work shows the results of a pilot methodology, designed after a series of observations and documented from 2006, on the process of acquisition of Translation Competence （TC） of students of translation. This method of analysis, appointed Previous Protocol to Translation or PPT, emerged as an option in search of teaching strategies of translation. This PPT has provided data not only on how novice translators acquire the translation competence, but it has been uncovered some independent variables that directly affect their development. There has been, in the four semesters analyzed in this work, a clear pattern that shows that an appropriate quality control to translate （and to carry out punctual terminology management） determines a better or worse quality of the final product （translations）; therefore, this reflects in a better translation competence in the novice students.
