速热柔光技术治疗光老化性皮肤病的临床疗效观察——附179例报告

目的:探讨速热柔光技术治疗颜面部光老化性皮肤病的临床疗效。方法:采用速热柔光治疗仪治疗179例颜面部光老化性皮肤病患者。其中色素斑68例,细小皱纹62例,毛孔粗大30例,毛细血管扩张19例。治疗参数:波长400～1200nm,光斑大小11mm×35mm,单发脉冲,脉宽35ms,能量密度10J/cm2。每次治疗间隔为3～4周,治疗5～6次为1个疗程,每例治疗1个疗程,疗程结束后6个月评价疗效。结果:显效96例(53.6%),有效65例(36.3%),无效18例(10%),总有效率为90%。结论:速热柔光技术疗效确切,不良反应少,为颜面部光老化皮肤病的治疗提供了新的选择。

空气污染与外源性皮肤老化

外源性皮肤老化是由于众多外部因素综合作用导致的,如:日光暴露、吸烟、空气污染等。近些年,随着全球部分地区空气污染的加重,空气污染与皮肤老化的关系成为一个新的研究热点。许多近期的调查研究证实空气污染能加速皮肤老化。研究空气污染与外源性皮肤老化的关系,可以为延缓外源性皮肤衰老提供新的对策。

Characterization and antioxidant activities of marine pepsin soluble collagen from the skin of yellow goosefish Lophius litulon

Characteristics and antioxidant activities of pepsin-soluble collagen （PSC） from yellow goosefish （Lophius litulon） skins were investigated. PSC was characterized as a type I collagen, and its imino acid content was 193 residues/1 000 residues. PSC＇s denaturation temperature was -17.56℃ and Fourier transform infrared spectra confirmed the presence of triple helices. Solubility analysis showed good solubility at acidic pH （1-6） or low NaCl concentrations （≤2%）. PSC showed scavenging activity against hydroxyl radicals and superoxide anions in a concentration-dependent manner. Furthermore, PSC could protect D-galactose-induced skin aging by significantly controlling malondialdehyde formation and improving the activity of superoxide dismutase, glutathione peroxidase, catalase, glutathione, and hydroxyproline. PSC may be a promising antioxidant in appropriate applications.