随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前...随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前有几种不同的治疗策略:保守治疗、微创手术及传统开放性手术治疗。目前临床医生大多首选微创手术治疗,因其治疗效果好且见效快,但针对各种不同实际病情的患者,要选择适合患者的治疗方案。近些年来,为了患者获得更好的预后,医生们也不断对每种治疗方式研究改进,该文旨在对OVCF的治疗进展作一综述。With the aging of the world, the incidence of osteoporotic vertebral compression fracture (OVCF) is increasing. The main manifestations of patients are pain in the lower back and limited activity, which seriously affect the quality of life of patients. So the key to early diagnosis and treatment of quite, there are several different treatment strategies: conservative treatment, minimally invasive surgery and traditional open surgery. At present, most clinicians prefer minimally invasive surgery because of its good therapeutic effect and quick effect. However, for patients with different actual conditions, we should choose the appropriate treatment plan for the patient. In recent years, in order to get better prognosis patients, doctors and continuous improvement for each treatment study, this paper aims to review summarized the progress in treatment of OVCF.展开更多
文摘随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前有几种不同的治疗策略:保守治疗、微创手术及传统开放性手术治疗。目前临床医生大多首选微创手术治疗,因其治疗效果好且见效快,但针对各种不同实际病情的患者,要选择适合患者的治疗方案。近些年来,为了患者获得更好的预后,医生们也不断对每种治疗方式研究改进,该文旨在对OVCF的治疗进展作一综述。With the aging of the world, the incidence of osteoporotic vertebral compression fracture (OVCF) is increasing. The main manifestations of patients are pain in the lower back and limited activity, which seriously affect the quality of life of patients. So the key to early diagnosis and treatment of quite, there are several different treatment strategies: conservative treatment, minimally invasive surgery and traditional open surgery. At present, most clinicians prefer minimally invasive surgery because of its good therapeutic effect and quick effect. However, for patients with different actual conditions, we should choose the appropriate treatment plan for the patient. In recent years, in order to get better prognosis patients, doctors and continuous improvement for each treatment study, this paper aims to review summarized the progress in treatment of OVCF.
文摘目的调查老年人骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)的相关影响因素,为减少OVCF的发生确定重点关注人群,丰富理论依据。方法选取OVCF患者119例为OVCF组、同期主诉腰背痛的非OVCF患者119例为对照组,对两组患者进行年龄、性别、体质量指数(body mass index,BMI)、入院血液结果及骨密度(bone mineral density,BMD)等基本情况调查,通过单因素和多因素Logistic回归分析影响OVCF发生的风险因素,并计算独立影响因素的联合概率,绘制ROC曲线。结果单因素分析:OVCF组有更高的年龄、BMI、糖尿病人群构成比及更低的预后营养指数(prognostic nutritional index,PNI)、BMD(均为P<0.05);多因素分析:高PNI是OVCF发生的保护因素,高龄、低BMD、BMI≥28 kg/m^(2)、伴随糖尿病是OVCF发生的独立危险因素(均为P<0.05);PNI、BMD、年龄的线性趋势明显(P for tread<0.05);不同的性别中,各独立危险因素OR值方向一致,高BMD、PNI的OR<1,高龄、高BMI及伴随糖尿病的OR>1。ROC:相对无PNI组,五项独立因素联合概率ROC曲线:敏感度提高5.9%,AUC提高0.0451(P=0.0064)。结论PNI、BMD、年龄、BMI、伴随糖尿病是OVCF发生的独立影响因素,其中反映营养及免疫状况的PNI对OVCF有重要的预测价值。
