To examine the age-and gender-specific 5-year incidence of age-related mac ulopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykja vik. Population-based, prospective cohort study. The cohort wa...To examine the age-and gender-specific 5-year incidence of age-related mac ulopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykja vik. Population-based, prospective cohort study. The cohort was a population-b ased random sample of citizens 50 years and older. Of 1379 eligible subjects, 10 45 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5 -year follow-up examination in 2001. The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using t he international classification and grading system for ARM and AMD. Early ARM an d AMD were assessed by masked grading of stereo fundus photographs. Hypopigmenta tion developed at 5 years in 10.7%of people 50 to 59 years of age (95%confiden ce interval [CI], 6.9-14.4) and in 25.7%those 70 to 79 years of age (95%CI, 1 8.4-33.0) at baseline. Age-related macular degeneration developed in no one wh o was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4. 6%(95%CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and o lder at baseline. Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar popula tions.展开更多
Purpose: To study the relationship between age-related maculopathy (ARM)/age -related macular degeneration (AMD) and phakic refraction and between ARM/AMD a nd axial length. Methods: The study was a point prevalence s...Purpose: To study the relationship between age-related maculopathy (ARM)/age -related macular degeneration (AMD) and phakic refraction and between ARM/AMD a nd axial length. Methods: The study was a point prevalence study that included 6 63 randomly selected persons aged over 65 years. We measured axial length and re fraction. Fundus images were graded for ARM according to a modified Wisconsin Ag e-related Maculopathy Grading System standard. Data from both eyes were availab le from most participants. We analysed the results for both individual eyes and pairs. Results: The mean axial length was 23.22mm for right eyes and 23.21mm for left eyes. Women had a 0.57-mm shorter mean axial length than men. The mean re fraction was +1.0 dioptres (D) for right eyes and +0.9 D for left eyes. At 70 years of age women were more hypermetropic than men by 0.66 D. There was no sign ificant difference in refraction or axial length among the groups with different ARM stages. Conclusion: We found no statistically significant relationship betw een axial length/refraction and AMD/ARM. There was a statistically significant s ex difference in axial length and refraction, where women had shorter axial leng ths and were more hypermetropic than men.展开更多
文摘To examine the age-and gender-specific 5-year incidence of age-related mac ulopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykja vik. Population-based, prospective cohort study. The cohort was a population-b ased random sample of citizens 50 years and older. Of 1379 eligible subjects, 10 45 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5 -year follow-up examination in 2001. The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using t he international classification and grading system for ARM and AMD. Early ARM an d AMD were assessed by masked grading of stereo fundus photographs. Hypopigmenta tion developed at 5 years in 10.7%of people 50 to 59 years of age (95%confiden ce interval [CI], 6.9-14.4) and in 25.7%those 70 to 79 years of age (95%CI, 1 8.4-33.0) at baseline. Age-related macular degeneration developed in no one wh o was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4. 6%(95%CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and o lder at baseline. Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar popula tions.
文摘Purpose: To study the relationship between age-related maculopathy (ARM)/age -related macular degeneration (AMD) and phakic refraction and between ARM/AMD a nd axial length. Methods: The study was a point prevalence study that included 6 63 randomly selected persons aged over 65 years. We measured axial length and re fraction. Fundus images were graded for ARM according to a modified Wisconsin Ag e-related Maculopathy Grading System standard. Data from both eyes were availab le from most participants. We analysed the results for both individual eyes and pairs. Results: The mean axial length was 23.22mm for right eyes and 23.21mm for left eyes. Women had a 0.57-mm shorter mean axial length than men. The mean re fraction was +1.0 dioptres (D) for right eyes and +0.9 D for left eyes. At 70 years of age women were more hypermetropic than men by 0.66 D. There was no sign ificant difference in refraction or axial length among the groups with different ARM stages. Conclusion: We found no statistically significant relationship betw een axial length/refraction and AMD/ARM. There was a statistically significant s ex difference in axial length and refraction, where women had shorter axial leng ths and were more hypermetropic than men.
