Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonge...Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival(OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed.展开更多
The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 ye...The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 years） and 20 elderly adults （aged 68.1 ±4.9 years） were recruited and asked to press square number buttons （from 0 to 9） on an experimental touchscreen with their right index finger. The buttons＇ size changed during the experiment with six conditions （6, 8, 10, 12, 14 and 16 mm）. It was found that a decrease of the button size to l0 mm or below tended to increase the operation time and error rate, whereas it decreased the subjective overall operability of the touchscreen. Such effects were greater in the elderly adults than in the young adults. In addition, the reaction positions on the buttons were found to be close to the right side of them, which led the fingertip to approach the right outline of the buttons. These findings suggest that the use of small touch buttons should be minimised on touchscreens, especially for elderly users.展开更多
Objective: Up to 40% of women over 70 years with primary operable breast cancer in the UK are treated with primary endocrine therapy(PET) as an alternative to surgery. A variety of factors are important in determining...Objective: Up to 40% of women over 70 years with primary operable breast cancer in the UK are treated with primary endocrine therapy(PET) as an alternative to surgery. A variety of factors are important in determining treatment for older breast cancer patients. This study aimed to identify the patient and tumor factors associated with treatment allocation in this population.Methods: Prospectively collected data on treatment received(surgery vs. PET) were analysed with multivariable logistic regression using the variables age, modified Charlson Comorbidity Index(CCI), activities of daily living(ADL) score, Mini-Mental State Examination(MMSE) score, HER2 status, tumour size, grade and nodal status. Results: Data were available for 1,122 cancers in 1,098 patients recruited between February 2013 and June 2015 from 51 UK hospitals. About 78% of the population were treated surgically, with the remainder being treated with PET. Increasing patient age at diagnosis, increasing CCI score, large tumor size(5 cm or more) and dependence in one or more ADL categories were all strongly associated with non-surgical treatment(P<0.05).Conclusion: Increasing comorbidity, large tumor size and reduced functional ability are associated with reduced likelihood of surgical treatment of breast cancer in older patients. However, age itself remains a significant factor for non-surgical treatment; reinforcing the need for evidence-based guidelines.展开更多
文摘Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival(OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed.
文摘The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 years） and 20 elderly adults （aged 68.1 ±4.9 years） were recruited and asked to press square number buttons （from 0 to 9） on an experimental touchscreen with their right index finger. The buttons＇ size changed during the experiment with six conditions （6, 8, 10, 12, 14 and 16 mm）. It was found that a decrease of the button size to l0 mm or below tended to increase the operation time and error rate, whereas it decreased the subjective overall operability of the touchscreen. Such effects were greater in the elderly adults than in the young adults. In addition, the reaction positions on the buttons were found to be close to the right side of them, which led the fingertip to approach the right outline of the buttons. These findings suggest that the use of small touch buttons should be minimised on touchscreens, especially for elderly users.
基金funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant No. RP-PG-1209-10071)
文摘Objective: Up to 40% of women over 70 years with primary operable breast cancer in the UK are treated with primary endocrine therapy(PET) as an alternative to surgery. A variety of factors are important in determining treatment for older breast cancer patients. This study aimed to identify the patient and tumor factors associated with treatment allocation in this population.Methods: Prospectively collected data on treatment received(surgery vs. PET) were analysed with multivariable logistic regression using the variables age, modified Charlson Comorbidity Index(CCI), activities of daily living(ADL) score, Mini-Mental State Examination(MMSE) score, HER2 status, tumour size, grade and nodal status. Results: Data were available for 1,122 cancers in 1,098 patients recruited between February 2013 and June 2015 from 51 UK hospitals. About 78% of the population were treated surgically, with the remainder being treated with PET. Increasing patient age at diagnosis, increasing CCI score, large tumor size(5 cm or more) and dependence in one or more ADL categories were all strongly associated with non-surgical treatment(P<0.05).Conclusion: Increasing comorbidity, large tumor size and reduced functional ability are associated with reduced likelihood of surgical treatment of breast cancer in older patients. However, age itself remains a significant factor for non-surgical treatment; reinforcing the need for evidence-based guidelines.
