吴坚老长逝周年祭

四十年前幸与逢，师我立言德相从。杏林练兵谋艺精，讲席育才求睿丰。

南京老站台

中山码头：汽笛声消失在风中 浪花从江面一层层扑打而来,敲击着斑驳的石块,碎裂的水珠腾空而起,在阳光中化作一团朦胧的水雾,飘落在岸边的野花上。江畔,一座码头孤零零地立着,阳光把它并不高大的影子拉得老长,码头的候船大厅里,稀稀疏疏坐着不多的人,显得有点冷清。客轮靠岸了,悦耳的汽笛声从江面传来,清脆得如同来自云间的鸟的鸣叫。

韩中山棚杂戏初探——兼论山棚假面戏与傩戏之关系

山棚杂戏是韩中传统假面戏的主要传承途径之一,而韩国的《老长戏》和中国的《大头和尚》都与傩戏有不可分的关系。因此,笔者对韩中山棚杂戏的关系进行了初步探讨兼论山棚假面戏与傩戏之关系,得到如下三个结论:第一,宋朝的鳌山杂戏和高丽的山台杂戏就其活动性质和表演情况基本一致。但14世纪以后,韩中之间的差别越来越大。朝鲜的山台杂戏,跟明清的鳌山杂戏不同,其主要目的限于宾礼即接待明使或清使,这一点也让笔者认为山台杂戏本来与佛教有着密不可分的关系。第二,笔者认为韩中两国的《老长戏》和《大头和尚》都来源于同一个源头,日本《教训抄》所载的伎乐为其有力的源头之一。第三,《大头和尚》与傩戏之关系是不容易下定论的问题之一,但从秧歌的角度来看,可以说《大头和尚》和《老长戏》都与傩戏有密切关系。

读

在城市里生活,我每天都提心吊胆,因为我的胃实在已经'伤不起'了。这不,去年暑假我特地回老家过了几天安稳日子。1虽然在老家很安稳,但是这天也实在是够热的。麦浪翻滚变成了热浪翻滚,小路旁的野草也都垂下了脑袋,树上的知了也在狂叫:'热死了.渴死了.'就连那平日见到我都要堂前屋后跑上很多圈的大黄狗也趴在地上,舌头伸得老长,大口大口地喘着粗气。

百岁老人

[幕启:场上有桌、凳.老人满头白发,身着艳丽的坎肩上.形体动作眼神及说话的口气不像百岁之人,也就八十多岁吧.老人乐哈哈,手摇大号拨浪鼓,有节奏地摇着,开鸡笼,鸡叫声响起,端着簸箕,口中念念有词.

Effects of Aging on the Proliferation and Differentiation Capacity of Human Periodontal Ligament Stem Cells

periodontal ligament stem cells; aging; proliferation; osteogenic differentiation Objective The aim of this study is to investigate the proliferation, differentiation and apoptosis of periodontal ligament stem cells （PDLSC） derived from different aged donors, and to evaluate the effects of aging on the biological characteristics of PDLSC. Methods Periodontal ligament tissues were obtained from 24 surgically extracted human premolars during orthodontics therapy. The specimens were divided into three groups according to the donor’s age. Group A： 18-20 years, group B： 30-35 years, group C： 45-50 years. PDLSC were isolated and cultured using a tissue-block-based enzymolytic method by limiting dilution assay. The colony forming efficiency of PDLSC for three experimental groups was determined. Senescence-Associated β-Galactosidase （SA-β-G） expression in the three groups was examined using β-galactosidase staining working solution. Cell cycle and apoptosis of the PDLSC were examined by the flow cytometry. Alkaline phosphatase （ALP） activity was evaluated by ALP staining. The expression of osteoplastic differentiation related genes Runt-related transcription factor-2 （Runx-2）, Collagen Type 1 （col-1）, and ALP of PDLSC were examined by quantitative real-time RT-PCR. Results The colony forming efficiency of PDLSC in Group A, B and C was 36.67%, 22.67% and 9.33%, respectively, which decreased with donors’ age （P〈0.05）. SA-β-G expression of the senescent PDLSC in group A, B and C were 4.14%, 16.39%, 50.38%, respectively （P〈0.05）. Cells in G2/S phase was 38.73%, 29.88%, 18.25% （P〈0.05）, and the apoptosis rate was 1.57%, 4.56%, 5.84% （P〈0.05）, in group A, B and C respectively. The ALP staining in the three groups decreased with the increase of donors’ ages, and the expression of Runx-2, col-1 and ALP decreased gradually from group A to group C （all P〈0.05）, which indicated the osteogenic differentiation capacity of PDLSC decreased while donor aging. Conclusion Human PDLSC could be successfully isolated from periodontal ligament tissues of different aged donors. However, the proliferation and osteogenic differentiation capacity of PDLSC decreased while donor aging.

Geriatric cardiology and the Great Wall International Congress of Cardiology 2015

The burgeoning geriatric population worldwide has resulted in an unprecedented challenge to the cardiology community. Cardiovascular disease is the major cause of morbidity and mortality in the elderly population, but its recognition and management are characteristically confounded by substantial comorbidities, polypharmacy, and other complexities of care, not encountered in younger cardiac patients.

Variability in local action potential durations, dispersion of repolarization and wavelength restitution in aged wild-type and Scn5a^＋/- mouse hearts modeling human Brugada syndrome

Brugada syndrome is a primary arrhythmia syndrome characterized by loss-of-function mutations in the SCN5A gene, which encodes for the cardiac Na^＋ channel. In affected individuals, the risk of developing malignant ventricular arrhythmias and sudden cardiac death are increased.

Analysis of Growth and Quality of Sun-cured Tobacco Kadsura Coccinea In Guangchang County

[Objective] The aim was to study the growth and quality characteristics of sun-cured tobacco Kadsura Coccinea in Guangchang County and give full play to its advantages. [Method] The research took tobacco varieties including Tiechi in Yiqian, Mushao in Yangxi Tiechi in Chishui, and Liuye in Toupo as test materials to explore development process, quality characteristics and economic traits of different varieties. [Result] The variety of Tiechi in Yiqian had medium growht, moderate growth periods, and the best economic benefits. Total content of aroma matter was the highest in the varieties of Tiechi in Yiqian. Also it had more content of products of browning reaction and products degraded by cembranoids. Besides, volume and quality of aroma were higher, as well as the score of sensory quality. [Conclusion]Comprehensive comparisons suggested that the variety of Tiechi in Yiqian was superior to others at tobacco-growing, economic benefits and quality.

Dignity and its related factors among older adults in long-term care facilities:A cross-sectional study

Objectives:This study aimed to explore the dignity and related factors among older adults in long-term care facilities.Methods:Cross-sectional data were obtained from a sample of 253 Chinese older adults dwelling in long-term care facilities.Dignity among older adults was measured using the Dignity Scale,and its potential correlates were explored using multiple linear regressions.Results:Results showed that the total score of the Dignity Scale is 151.95±11.75.From high to low,the different factors of dignity among older adults in long-term care facilities were as follows:caring factors(4.83±0.33),social factors(4.73±0.41),psychological factors(4.66±0.71),value factors(4.56±0.53),autonomous factors(4.50±0.57),and physical factors(4.38±0.55).A higher score of the Dignity Scale was associated with higher economic status,fewer chronic diseases,less medication,better daily living ability and long-time lived in cities.Conclusion:Older adults with low economic status,more chronic diseases,and poor daily living ability,taking more medications,or the previous residence in rural areas seem to be most at low-level dignity in long-term care facilities and thus require more attention than their peers.

Semantic Region Estimation of Assistant Robot for the Elderly Long-Term Operation in Indoor Environment

In this work, in order to improve spatial recognition abilities for the long-term operation tasks of the assistant robot for the elderly, a novel approach of semantic region estimation is proposed. We define a novel graphbased semantic region descriptions, which are estimated in a dynamically fashion. We propose a two-level update algorithm, namely, Symbols update level and Regions update level. The algorithm firstly adopts particle filter to update weights of the symbols, and then use the Viterbi algorithm to estimate the region the robot stays in based on those weights, optimally. Experimental results demonstrate that our proposed approach can solve problems of the long-term operation and kidnapped robot problem.

New insights into the role of PML in tumour suppression

The PML gene is involved in the t（15;17） translocation of acute promyelocytic leukaemia （APL）, which generates the oncogenic fusion protein PML （promyelocytic leukaemia protein）-retinoic acid receptor alpha. The PML protein localises to a subnuclear structure called the PML nuclear domain （PML-ND）, of which PML is the essential structural component. In APL, PML-NDs are disrupted, thus implicating these structures in the pathogenesis of this leukaemia. Unexpectedly, recent studies indicate that PML and the PML-ND play a tumour suppressive role in several different types of human neoplasms in addition to APL. Because of PML＇s extreme versatility and involvement in multiple cellular pathways, understanding the mechanisms underlying its function, and therefore role in tumour suppression, has been a challenging task. In this review, we attempt to critically appraise the more recent advances in this field and propose new avenues of investigation.

Shenfu injection plus vinorelbine for elderly patients with non-small cell lung cancer in promoting the quality of life: a randomized controlled clinical trial

Objective： The present study aimed to investigate the efficacy of Shenfu injection plus vinorelbine on the promotion of the quality of life （QOL） in elderly non-small cell lung cancer （NSCLC） patients. Methods： A randomized single blind trial method was used. Forty-six patients with stage IIIB-IV of HSCLC were randomly divided into experimental group and control group. In the experimental group, the patients were treated with 50 mL Shenfu injection from day 1 to 14, plus vinorelbine （NVB） 25 mg/m^2 on day 1 and 8. In the control group, the patients were only treated with NVB 25 mg/m^2 on day 1 and 8. After two cycle＇s of treatment, QOL, efficacy and toxicity were observed. Results： The QOL was enhanced in both experimental group and control group. However, the difference of KPS after treatment in the experimental group was markedly higher than in the control group （14 ± 10 vs. 8 ± 10, t = 2.116, P = 0.04）, improvement rate of QOL was better than in the control group （76.2% vs. 45.0%, χ^2 = 4.188, P = 0.041）, treatment related toxicity in the experimental group was also markedly lower than in the control group （χ^2 = 3.866, P = 0.049）, but the difference of efficacy between the two groups was not significant （14.3% vs. 15.0%, χ^2 = 0.161, P = 0.688）. Conclusion： Shenfu injection plus vinorelbine can enhance QOL in elderly NSCLC patients.

Stock Market Development in Country With Least Development But Fast Economic Growth： A Case Study of Lao PDR

This paper aims to examine the market development evolution of Lao Securities Exchange （LSX） by observing the institutional structure, securities regulations, and government’s policy and utilizing the annual data of market indicators from 2011 to 2017 through the regression model in order to determine the facing issues with proposing the resolution implication for securities exchange development. The finding of this paper also concludes that the liquidity issue, small number of listed firms, undiversified products, small investor base, insufficient legislation from regulatory body, and slow progress in transforming state-owned enterprises （SOEs） into public companies are the current pressure obstacles for securities market development in Laos. In this case, there is a need for stronger commitment from government in securities market development by closer collaboration among line ministries, enlarging the investor base to public and private sectors, acknowledging the significance of drafting the public company act, and persuading the SOEs to issue initial public offering （IPO） in LSX, as the result would drive positive impacts to stimulate the capital market development in Lao People’s Democratic Republic （Lao PDR）.

Transcatheter aortic valve implantation in very elderly patients： immediate results and medium term follow-up

Objective To evaluate immediate transcatheter aortic valve implantation （TAVI） results and medium-term follow-up in very elderly pa- tients with severe and symptomatic aortic stenosis （AS）. Methods This multicenter, observational and prospective study was carried out in three hospitals. We included consecutive very elderly （〉 85 years） patients with severe AS treated by TAVI. The primary endpoint was to evaluate death rotes from any cause at two years. Results The study included 160 consecutive patients with a mean age of 87 ± 2.1 years （range from 85 to 94 years） and a mean logistic EuroSCORE of 18.8% ± 11.2% with 57 （35.6%） patients scoring 〉 20%. Procedural success rate was 97.5%, with 25 （15.6%） patients experiencing acute complications with major bleeding （the most frequent）. Global mortality rate during hospitalization was 8.8% （n = 14） and 30-day mortality rate was 10% （n = 16）. Median follow up period was 252.24± 232.17 days. During the follow-up period, 28 （17.5%） patients died （17 of them due to cardiac causes）. The estimated two year overall and cardiac survival rates using the Kaplan-Meier method were 71% and 86.4%, respectively. Cox proportional hazard regression showed that the variable EuroSCORE ≥ 20 was the unique vari- able associated with overall mortality. Conclusions TAVI is safe and effective in a selected population of very elderly patients. Our findings support the adoption of this new procedure in this complex group of patients.

Effects of the New Two-child Policy On Family Old-age Security

This paper analyzes the current situation of the aging population and low fertility rate.lt is found that the aging process is accelerated, the population growth potential is decreased, and the elderly dependency ratio is higher.Secondly, this paper mainly analyzes the impact of the new two-child policy on family pension security from three aspects： population policy, family support and social security.There are two aspects of the effects, the positive effects are：improve fertility, reduce elderly dependency ratio, relieve population aging,enhance the family development： the negative effects are： tremendous pressure on public resources, further inequality in birth right, heavy economic pressure on the family.At last. this paper puts forward the constructive countermeasures against the problems of the policy and the was out of the family old-age security.

Nuclear power plant life extension:How aging affects performance of containments & other structures

This paper focuses on how aging can affect performance of safety-related structures in nuclear power plant (NPP). Knowledge and assessment of impacts of aging on structures are essential to plant life extension analysis,especially performance to severe loadings such as loss-of-coolant-accidents or major seismic events. Plant life extension issues are of keen interest in countries (like the United States) which have a large,aging fleet of NPPs. This paper addresses the overlap and relationship of structure aging to severe loading performance,with particular emphasis on containment structures.

There alone the spirit of family endowment problem research

Since the 80 s, our country is working on implementing birth limitation and having only one, ＂one of the most glorious＂ policy, the policy is very good solve the problem of China＇s population rising too rapidly, at the same time also the certain negative impact. In other words, lose the sole group production is to limit the second child victims. Of course, only child＇s death is the biggest hidden trouble, this not only can bring economic loss to lose alone group, will give group cause huge loss alone cannot make up for the spiritual loss. If only children died, their relatives and friends, especially the parents very easily into the depression, are not interested in anything, their thoughts are on the verge of collapse, it is also a need to study and to explore the topic.

EFFECTS OF EARLY NUTRITION INTERVENTION ON IGF1, IGFBP3,INTESTINAL DEVELOPMENT, AND CATCH-UP GROWTH OF INTRAUTERINE GROWTH RETARDATION RATS

To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1),insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet. Methods IUGR rat model was built by starvation of pregnant female rats. Twenty-four IUGR pups and 8 normal pups were divided randomly into 4 groups: normal control group (C group); IUGR control group(S group), IUGR low-protein diet group (SL group), and IUGR high-protein diet group (SH group). Detected the serum IGF1, IGFBP3, body weight, body length, intestinal weight length, intestinal villi height (VH), crypt depth (CD), villi absorbing area (VSA), mucous thickness (MT), and disaccharidase at the 4th week. Results (1) The SH group showed the fastest catch-up growth, serum IGF1, IGFBP3, VH, and VSA were significantly higher than those of normal control group and IUGR control group. The intestinal weight and length, and the activities of lactase and saccharase of the SH group also reached the normal control group level. (2) The SL group kept on small size, the serum IGF1, IGFBP3, and most of intestinal histological indexes were all significantly lower than other groups. (3) IGF-1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length. Conclusions The serum IGF1 was a sensitive index to the catch-up growth. The early nutritional intervention of high-protein diet after birth is helpful for the catch-up growth of IUGR through promoting the intestinal development and the ab-sorption of nutrition

Effects of Sublethal Doses of Chlorfluazuron on Ovarioles in the Common Cutworm, Spodoptera Litura （F.） （Lepidoptera： Noctuidae）

Chlorfluazuron is an insect growth regulator for controlling the major insect pests in crops. This paper describes the effects of sublethal doses （LD10：1.00 ng/larva; LD30：3.75 ng/larva） of chlorfluazuron on ovarioles during ovarian development and oogenesis of common cutworm, Spodoptera litura （F.）. It is a significant pest of cotton, tobacco and miscellaneous vegetables. The LDlo or LD3o was applied topically to the newly-ecdysed fifth-instars of S. litura under laboratory conditions. In controls, on 2nd day of adult emergence, the cell density in germarium was 1636 ± 9.17 nuclei/mm^2. It increased until 3rd day, i.e., 1829 ± 8.87 nuclei/mm^2 and decreased thereafter. In the LDloor LD-3o-treated insects, the patterns of the cell density was the same as in controls but values were significantly （P 〈 0.05） decreased in the LD10- and more in the LDa0-treated females compared with controls. In control, ovaries were normal type and had mature ova with an occasional one or two being absorbed. In LD10-treated females, ovaries had spaces in ovarioles and absorption of ova. In LD30-treated females, besides the spacing and absorption, sometimes only immature （germarium） ova were found.