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Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine via the splenic vein 被引量:2
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作者 Yan-Yan Zhang Chao-Xu Zhang +6 位作者 Yu Li Xuan Jiang Yong-Fang Wang Yang Sun Jun Wang Wan-Ying Ji Yi Liu 《World Journal of Gastroenterology》 SCIE CAS 2018年第44期5005-5012,共8页
AIM To develop a novel rat model of heterogeneous hepatic injury.METHODS Seventy male Sprague-Dawley rats were randomly divided into a control group(n = 10) and a colchicine group(n =60). A 0.25% colchicine solution(0... AIM To develop a novel rat model of heterogeneous hepatic injury.METHODS Seventy male Sprague-Dawley rats were randomly divided into a control group(n = 10) and a colchicine group(n =60). A 0.25% colchicine solution(0.4 mL/kg) was injected via the splenic vein in the colchicine group to develop a rat model of heterogeneous hepatic injury. An equal volume of normal saline was injected via the splenic vein in the control group. At days 3, 7, and 14 and weeks 4, 8, and 12 after the operation, at least seven rats of the colchicine group were selected randomly for magnetic resonance imaging(MRI) examinations, and then they were euthanized. Ten rats of the control group underwent MRI examinations at the same time points, and then were euthanized at week 12. T2-weighted images(T2 WI) and diffusion weighted imaging(DWI) were used to evaluate the heterogeneous hepatic injury. The heterogeneous injury between the left and right hepatic lobes was assessed on liver sections according to the histological scoring criteria, and correlated with the results of MRI study. RESULTS Obvious pathological changes occurred in the hepatic parenchyma in the colchicine group. Hepatic injury scores were significantly different between the left and right lobes at each time point(P < 0.05). There was a significant difference in apparent diffusion coefficient(ADC) of DWI and liver-to-muscle ratio(LMR) of T2 WI between the left and right lobes of rats in the colchicine group(P < 0.05) at each time point, and similar results were observed between the colchicine and control groups. Besides, there was a significant correlation between hepatic injury scores and ADC values or LMR(r =-0.682, P = 0.000; r =-0.245, P = 0.018).CONCLUSION Injection with colchicine via the splenic vein can be used to successfully develop a rat model of heterogeneous hepatic injury. DWI and T2 WI may help evaluate the heterogeneous injury among liver lobes. 展开更多
关键词 Heterogeneous hepatic injury Rat model COLCHICINE T2-weighted images Diffusion weighted imaging
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森林王国
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作者 刘启凤 《戏剧文学》 北大核心 2006年第6期15-26,共12页
时间未来的某个时候。地点大森林里。人物笨笨小熊。小白小白兔。蓝皮“老鼠网吧”的老板。花花“老鼠网吧”的女服务员。老虎森林王国的国王。黑猫森林王国的警长。爸爸小熊笨笨的爸爸。妈妈兔子小白的妈妈。笨笨妈小熊笨笨的妈妈。狐... 时间未来的某个时候。地点大森林里。人物笨笨小熊。小白小白兔。蓝皮“老鼠网吧”的老板。花花“老鼠网吧”的女服务员。老虎森林王国的国王。黑猫森林王国的警长。爸爸小熊笨笨的爸爸。妈妈兔子小白的妈妈。笨笨妈小熊笨笨的妈妈。狐狸、哼哼猪教授、百灵鸟记者、众动物若干。第一场森林王国。画外音这里是世界上最后一个动物王国部落。在这里,动物们过着自由、 展开更多
关键词 老鼠花 老虎 妈妈 国王 狐狸 王国 国家形式 森林
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