AIM: To find the most reproducible quantitative parameter of a standard 13C-methacetin breath test (13C-MBT). METHODS: Twenty healthy volunteers (10 female, 10 male) underwent the 13C-MBT after intake of 75 mg 13C-met...AIM: To find the most reproducible quantitative parameter of a standard 13C-methacetin breath test (13C-MBT). METHODS: Twenty healthy volunteers (10 female, 10 male) underwent the 13C-MBT after intake of 75 mg 13C-methacetin p.o. on three occasions. Short-and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively. RESULTS: The reproducibility of the 1-h cumulative 13C recovery (AUC0-60), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary 13C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle 13C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three weeks.Regarding the AUC0-60, the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the 13C-MBT reproducibility. CONCLUSION: 13C-MBT is most reproducibly quantified by the cumulative 13C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.展开更多
A row of dominoes which stand on edge will undergo a cascade when the first domino is tipped. First domino strokes the next and the wave of falling dominoes propagates. The purpose of this work is to investigate wave ...A row of dominoes which stand on edge will undergo a cascade when the first domino is tipped. First domino strokes the next and the wave of falling dominoes propagates. The purpose of this work is to investigate wave speed dependence on various domino parameters as the number of elements and the distance between dominoes and their dimensions. Theoretical examination of falling dominoes process is to create the mathematical model of the process and compare between the calculations and experimental results. An experiment with using of the speed camera was made. The dominoes of three different types of material were used. For theoretical investigation of the problem, the model [1] was used. The program for computer calculations was written. Time of a dominoes row falling was calculated without taking friction between neighbours. The calculation results show that the speed of falling dominoes reaches its constant value. This stable velocity depends on the geometric parameters of dominoes and the surface friction between dominoes but does not depend on the mass of dominoes.展开更多
基金Supported by The Medical University of Silesia, contracts No. NN-1-106-06, KNW-1-043/08 and KNW-1-154/09
文摘AIM: To find the most reproducible quantitative parameter of a standard 13C-methacetin breath test (13C-MBT). METHODS: Twenty healthy volunteers (10 female, 10 male) underwent the 13C-MBT after intake of 75 mg 13C-methacetin p.o. on three occasions. Short-and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively. RESULTS: The reproducibility of the 1-h cumulative 13C recovery (AUC0-60), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary 13C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle 13C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three weeks.Regarding the AUC0-60, the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the 13C-MBT reproducibility. CONCLUSION: 13C-MBT is most reproducibly quantified by the cumulative 13C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.
文摘A row of dominoes which stand on edge will undergo a cascade when the first domino is tipped. First domino strokes the next and the wave of falling dominoes propagates. The purpose of this work is to investigate wave speed dependence on various domino parameters as the number of elements and the distance between dominoes and their dimensions. Theoretical examination of falling dominoes process is to create the mathematical model of the process and compare between the calculations and experimental results. An experiment with using of the speed camera was made. The dominoes of three different types of material were used. For theoretical investigation of the problem, the model [1] was used. The program for computer calculations was written. Time of a dominoes row falling was calculated without taking friction between neighbours. The calculation results show that the speed of falling dominoes reaches its constant value. This stable velocity depends on the geometric parameters of dominoes and the surface friction between dominoes but does not depend on the mass of dominoes.
