AIM:To evaluate the effects of fucoidan,a complex sulfated polysaccharide extract from marine seaweed,on hepatitis C virus(HCV) RNA load both in vitro and in vivo.METHODS:HCV-1b replicon-expressing cells were cultured...AIM:To evaluate the effects of fucoidan,a complex sulfated polysaccharide extract from marine seaweed,on hepatitis C virus(HCV) RNA load both in vitro and in vivo.METHODS:HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa,Japan,and quantified the level of HCV replication.In an open-label uncontrolled study,15 patients with chronic hepatitis C,and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan(0.83 g/d) for 12 mo.The clinical symptoms,biochemical tests,and HCV RNA levels were assessed before,during,and after treatment.RESULTS:Fucoidan dose-dependently inhibited the expression of HCV replicon.At 8-10 mo of treatment with fucoidan,HCV RNA levels were significantly lower relative to the baseline.The same treatment also tended to lower serum alanine aminotransferase levels,and the latter correlated with HCV RNA levels.However,the improved laboratory tests did not translate into significant clinical improvement.Fucoidan had no serious adverse effects.CONCLUSION:Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCVrelated chronic liver diseases.Further controlled clinical trials are needed to confirm the present findings.展开更多
Phenotypic plasticity and/or pollinatormediated selection may be responsible for the changes in floral traits of plants when they are forced to live in new conditions. Although the two events could be independent, we ...Phenotypic plasticity and/or pollinatormediated selection may be responsible for the changes in floral traits of plants when they are forced to live in new conditions. Although the two events could be independent, we hypothesized that phenotypic plasticity in floral traits might help to coordinate plant-pollinator interactions and enhance plant reproductive success in changing habitats. To test this hypothesis, we investigated floral traits and pollination on three natural populations of a lousewort(Pedicularis siphonantha) ranging at different elevations, as well as two downward transplanted populations in Shangeri-La County and Deqin County, northwest Yunnan, China. The results indicated that floral traits, i.e. phenology, longevity,display size, corolla tube length and pollen production differed significantly among populations. Moreover,or the two transplanted populations, floral traits diverged from their original populations, but converged to their host populations. Although the phenotypic plasticity in floral traits might be a rapid response to abiotic factor such as warmer environment, the changes in floral traits were found to be well adapted to pollination environment of the host population. Compared with plants of their original habitats in higher elevation, the transplanted individuals advanced flowering time, shortened flower longevity, reduced floral display size and pollen production, received higher visiting frequency and yielded more seeds. These findings suggested that phenotypic plasticity of floral traits might help plants adjust their resource allocation strategy between preand post-pollination stages in response to harsh or temperate conditions, which might correspondingly meet a pollinator-poor or hyphen rich environment.This would be beneficial for the widely-distributed species to adapt to various environmental changes.展开更多
Since 1949, Chinese scientists have successfully predicted occurrence of many major earthquakes, such as the Haicheng MT. 3 event in 1975 and the Asian Game Village shock of 1990. In recent 20 years, however, some sei...Since 1949, Chinese scientists have successfully predicted occurrence of many major earthquakes, such as the Haicheng MT. 3 event in 1975 and the Asian Game Village shock of 1990. In recent 20 years, however, some seis-mologists abroad have taken a disappointed and pessimistic view to earthquake prediction because of several failures. They suggest that the efforts should turn toward other fields, such as identification of building＇ s earthquake-proof capability, enhancement of house strength, and development of precise observational systems which will facilitate fast loca- ting of future major temblors and emergent relief on site. Such a pessimistic feeling has also influenced some Chinese researchers of the seismological community who attempted to give up efforts for earthquake prediction. Meanwhile other scientific workers are insisting in experiments and practices in this field and achieved some inspiring results. In this paper, we present several representative cases to illustrate that earthquakes are predictable under some conditions.展开更多
The MARGov Project consisted in strengthening the interaction among the Professor Luiz Saldanha Marine Park stakeholders, and to collaboratively construct, with social and institutional actors, a governance model for ...The MARGov Project consisted in strengthening the interaction among the Professor Luiz Saldanha Marine Park stakeholders, and to collaboratively construct, with social and institutional actors, a governance model for the Marine Park, located in the municipality of Sesimbra （Portugal）. To pursue this goal, a PPGIS （public participation geographic information system） was developed, allowing the interaction, discussion and public participation of the stakeholders and actors involved. This PPGIS emerged as a crowdsourcing tool, with the purpose of assisting the georeferenced contributes from the local users of the Marine Park, regarding several relevant subjects, such as pollution, economic activities, opportunities and threats to the Marine Park, providing visual, analytical, and demonstrative qualities.展开更多
文摘AIM:To evaluate the effects of fucoidan,a complex sulfated polysaccharide extract from marine seaweed,on hepatitis C virus(HCV) RNA load both in vitro and in vivo.METHODS:HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa,Japan,and quantified the level of HCV replication.In an open-label uncontrolled study,15 patients with chronic hepatitis C,and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan(0.83 g/d) for 12 mo.The clinical symptoms,biochemical tests,and HCV RNA levels were assessed before,during,and after treatment.RESULTS:Fucoidan dose-dependently inhibited the expression of HCV replicon.At 8-10 mo of treatment with fucoidan,HCV RNA levels were significantly lower relative to the baseline.The same treatment also tended to lower serum alanine aminotransferase levels,and the latter correlated with HCV RNA levels.However,the improved laboratory tests did not translate into significant clinical improvement.Fucoidan had no serious adverse effects.CONCLUSION:Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCVrelated chronic liver diseases.Further controlled clinical trials are needed to confirm the present findings.
基金supported by the National Natural Science Foundation of China (Grant No. 31370263 and 31770255)
文摘Phenotypic plasticity and/or pollinatormediated selection may be responsible for the changes in floral traits of plants when they are forced to live in new conditions. Although the two events could be independent, we hypothesized that phenotypic plasticity in floral traits might help to coordinate plant-pollinator interactions and enhance plant reproductive success in changing habitats. To test this hypothesis, we investigated floral traits and pollination on three natural populations of a lousewort(Pedicularis siphonantha) ranging at different elevations, as well as two downward transplanted populations in Shangeri-La County and Deqin County, northwest Yunnan, China. The results indicated that floral traits, i.e. phenology, longevity,display size, corolla tube length and pollen production differed significantly among populations. Moreover,or the two transplanted populations, floral traits diverged from their original populations, but converged to their host populations. Although the phenotypic plasticity in floral traits might be a rapid response to abiotic factor such as warmer environment, the changes in floral traits were found to be well adapted to pollination environment of the host population. Compared with plants of their original habitats in higher elevation, the transplanted individuals advanced flowering time, shortened flower longevity, reduced floral display size and pollen production, received higher visiting frequency and yielded more seeds. These findings suggested that phenotypic plasticity of floral traits might help plants adjust their resource allocation strategy between preand post-pollination stages in response to harsh or temperate conditions, which might correspondingly meet a pollinator-poor or hyphen rich environment.This would be beneficial for the widely-distributed species to adapt to various environmental changes.
文摘Since 1949, Chinese scientists have successfully predicted occurrence of many major earthquakes, such as the Haicheng MT. 3 event in 1975 and the Asian Game Village shock of 1990. In recent 20 years, however, some seis-mologists abroad have taken a disappointed and pessimistic view to earthquake prediction because of several failures. They suggest that the efforts should turn toward other fields, such as identification of building＇ s earthquake-proof capability, enhancement of house strength, and development of precise observational systems which will facilitate fast loca- ting of future major temblors and emergent relief on site. Such a pessimistic feeling has also influenced some Chinese researchers of the seismological community who attempted to give up efforts for earthquake prediction. Meanwhile other scientific workers are insisting in experiments and practices in this field and achieved some inspiring results. In this paper, we present several representative cases to illustrate that earthquakes are predictable under some conditions.
文摘The MARGov Project consisted in strengthening the interaction among the Professor Luiz Saldanha Marine Park stakeholders, and to collaboratively construct, with social and institutional actors, a governance model for the Marine Park, located in the municipality of Sesimbra （Portugal）. To pursue this goal, a PPGIS （public participation geographic information system） was developed, allowing the interaction, discussion and public participation of the stakeholders and actors involved. This PPGIS emerged as a crowdsourcing tool, with the purpose of assisting the georeferenced contributes from the local users of the Marine Park, regarding several relevant subjects, such as pollution, economic activities, opportunities and threats to the Marine Park, providing visual, analytical, and demonstrative qualities.
