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吉非替尼在非小细胞肺癌治疗中的耐药处理策略探讨 被引量:1
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作者 王远峰 栗钊 《中国社区医师》 2023年第10期10-12,共3页
目的:探讨吉非替尼在非小细胞肺癌治疗中的耐药处理策略。方法:选取2020年12月—2021年12月山东省鄄城县人民医院收治的69例吉非替尼耐药的非小细胞肺癌患者作为研究对象,根据随机数字表法分为三联合组与二联合组。二联合组采用吉非替... 目的:探讨吉非替尼在非小细胞肺癌治疗中的耐药处理策略。方法:选取2020年12月—2021年12月山东省鄄城县人民医院收治的69例吉非替尼耐药的非小细胞肺癌患者作为研究对象,根据随机数字表法分为三联合组与二联合组。二联合组采用吉非替尼联合顺铂治疗,三联合组在二联合组基础上增加培美曲塞二钠治疗。比较两组肿瘤直径及体积、治疗效果、肿瘤标志物水平、T淋巴细胞亚群指标水平、不良反应发生情况。结果:治疗后,三联合组肿瘤直径短于二联合组,肿瘤体积小于二联合组,差异有统计学意义(P<0.05)。三联合组治疗有效率和疾病控制率均高于二联合组,差异有统计学意义(P<0.05)。治疗后,三联合组肿瘤标志物、T淋巴细胞亚群指标水平优于二联合组,差异有统计学意义(P<0.05)。结论:吉非替尼耐药者联合培美曲塞二钠和顺铂治疗,可有效提升肿瘤控制效果,临床应用安全可靠。 展开更多
关键词 吉非替尼 非小细胞 肺癌 耐药处理
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Occurrence and Fate of Antibiotics in the Aqueous Environment and Their Removal by Constructed Wetlands in China: A review 被引量:24
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作者 GUAN Yidong WANG Bo +4 位作者 GAO Yongxia LIU Wen ZHAO Xiaoli HUANG Xiaofeng YU Jianghuai 《Pedosphere》 SCIE CAS CSCD 2017年第1期42-51,共10页
Overuse of antibiotics has become a serious ecological problem worldwide. There is growing concern that antibiotics are losing their effectiveness due to an increased antibiotic resistance in bacteria. During the last... Overuse of antibiotics has become a serious ecological problem worldwide. There is growing concern that antibiotics are losing their effectiveness due to an increased antibiotic resistance in bacteria. During the last twenty years, consumption of antibiotics has increased rapidly in China, which has been cited as one of the world's worst abusers of antibiotics. This review summarizes the current state of antibiotic contamination in China's three major rivers (the Yangtze River, Yellow River, and Pearl River) and illustrates the occurrence and fate of antibiotics in conventional municipal wastewater treatment plants (VC-VVTPs). The analytical data indicate that traditional W-WTPs cannot completely remove these concerned pharmaceuticals, as seen in the large difference between the distribution coefficient (Kd) and the uneven removal efficiency of various types of antibiotics. Although constructed wetlands (CWs) offer a potential way to remove these antibiotics from water supplies, knowledge of their mechanisms is limited. There are four main factors affecting the performance of CWs used for the treatment of antibiotics in water supplies, the types and configurations of CWs, hydraulic load rates, substrates, and plants and microorganisms. Further researches focusing on these factors are needed to improve the removal efficiency of antibiotics in CWs. 展开更多
关键词 antibiotic contamination biological degration municipal treatment plant POLLUTANTS water supplies
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