输卵管积水抽吸术配合耳穴贴疗对体外受精-胚胎移植结局的影响

目的探讨冷冻胚胎移植前输卵管积水处理的有效方法。方法将229例冷冻胚胎移植并伴有输卵管积水的患者,采用随机数字表进行分组。研究组为输卵管积水抽吸术配合耳穴贴疗组(A组)94例,输卵管积水抽吸组(B组)89例,输卵管积水未处理组(C组)46例作为对照组。比较3组患者冻融胚胎移植周期结局及移植日子宫内膜和内膜下血流分布。结果 3组患者的冻胚移植日子宫内膜厚度、移植胚胎数和移植的优质胚胎数比较,差异均无统计学意义(P>0.05);A组的临床妊娠率及胚胎种植率均明显高于C组,且临床妊娠率亦高于B组,差异均有统计学意义(P<0.05)。早期流产率与移植取消率A组明显低于C组,差异亦有统计学意义(P<0.05)。A组的子宫内膜和内膜下血流分布以A型分布为主,A型分布率均明显高于B组和C组;B组的A型分布率也高于C组,差异均有统计学意义(P<0.05)。结论输卵管积水抽吸配合耳穴贴疗方案处理输卵管积水能提高子宫内膜容受性,改善体外受精-胚胎移植的结局。

输卵管积水的不同治疗方法对冻融胚胎移植结局的影响

目的:探讨冻融胚胎移植(FET)前输卵管积水治疗的有效方案。方法:对FET伴有输卵管积水患者187例的临床资料进行回顾分析。其中行输卵管积水抽吸术配合耳穴贴疗组94例(抽吸耳贴组);行输卵管积水近端结扎及远端造口引流53例(结扎引流组);输卵管积水未治疗40例(未治疗组)。比较3组患者FET结局及移植日子宫内膜和内膜下血流分布。结果:3组患者一般情况均无统计学差异(P>0.05);抽吸耳贴组和结扎引流组的临床妊娠率、胚胎种植率及移植日子宫内膜和内膜下A型血流分布率均明显高于未治疗组(P<0.05),抽吸耳贴组与结扎引流组无统计学差异(P>0.05)。抽吸耳贴组早期流产率、移植取消率与结扎引流组也无统计学差异(P>0.05)。结论:输卵管积水抽吸配合耳穴贴疗方案治疗输卵管积水,简单有效且能提高体外受精-胚胎移植的累计妊娠率。

Acupuncture combined with ear point embedding for sleep disorder in depression

Objective To investigate clinical therapeutic effects of acupuncture combined with ear point embedding for treating sleep disorder in depression. Methods Seventy-six patients suffering from sleep disorder in depression were randomly divided into an observation group （39 cases） and a control group （37 cases）. In observation group, acupuncture at Baihui （百会 GV 20）, Shangxing （上星 GV 23）, Shenting （神庭 GV 24）, Fengchi （风池 GB 20） and Shenmen （神门 HT 7）, etc., which was combined with ear point embedding, and in control group, Fluoxetine Hydrochloride Dispersible tablet （Prozac） was orally given. Four weeks of treatments were given as a therapeutic course in both groups. Comparison of changes in scores of HAMD and PSQI was made between the two groups. Results After treatment, HAMD scores were obviously lowered in both groups （both P〈0.01）, and the reduction in HAMD score was more obvious in observation group than that in control group （P〈0.05）. After treatment, the reduction in PSQI score was more obvious in observation group （P〈0.01）, it was more significantly decreased than that in control group. Conclusion Acupuncture combined with ear point embedding provids remarkable therapeutic effects in treating sleep disorder in depression, which is superior to those provided by Fluoxetine Hydrochloride Dispersible Fablet orally given.

Current situation and analysis of clinical application of auricular acupoint sticking therapy

Objective： By the bibliometrical analysis and evaluation of acupuncture theses on auricular acupoint sticking from 2005 to 2014, the analysis was processed from multiple aspects including the types and numbers of diseases and effective rates of various diseases, in order to objectively reflect the general situation of clinical application of ear point embedding method in the recent years. Methods： By the bibliometrical analysis, the literature on auricular acupoint sticking in the recent ten years was counted up, analyzed and categorized. Results and Conclusion： Auricular acupoint sticking is used clinically for diseases of 26 systems, including 130 diseases. 74 diseases were singularly treated with auricular acupoint sticking, including the advantageous disease category like insomnia, constipation and obesity, and secondary advantageous disease category like dysmenorrhea, myopia, allergic rhinitis, post-operative pain and acne vulgaris.

Treatment of acne vulgaris with auricular acupoint pricking-bloodletting plus auricular point sticking therapy: a randomized controlled study

Objective: To observe the clinical efficacy of auricular point pricking-bloodletting plus auricular point sticking therapy for acne vulgaris. Methods: A total of 66 patients with acne vulgaris were randomized into an observation group and a control group by the random number table, with 33 cases in each group. The observation group was treated with auricular point pricking-bloodletting plus auricular point sticking therapy, and the control group was treated only with auricular point sticking therapy. The treatments of both groups were performed twice a week, 4 weeks as a course of treatment, for 3 courses in total. The scores of skin lesions and dermatology life quality index (DLQI) scores were recorded before and after treatment to assess the clinical efficacy. Results: During the trial, there were 3 cases of drop-out both in the observation group and the control group. After 3 courses of treatment, the total effective rate of the observation group was 96.7%, while that of the control group was 76.7%. The difference between the two groups was statistically significant (P<0.05). The intra-group comparison showed that the scores of skin lesion and DLQI were both decreased with the increase of treatment times, that was, the scores were lower than those at the previous time point (allP<0.05). After 1, 2, and 3 courses of treatment, the scores of skin lesion and DLQI of both groups were statistically different from those of the same group before treatment (allP<0.05). At every time point during the treatment, the scores of skin lesion and DLQI of the observation group were lower than those of the control group, and the differences between the two groups were statistically significant (all P<0.05). Conclusion: Auricular point pricking-bloodletting plus auricular point sticking has a better curative effect than auricular point sticking therapy alone in the treatment of acne vulgaris, and has a time-effect correlation.

Therapeutic efficacy observation on combining auricular and routine acupuncture for peripheral facial paralysis in acute stage

Objective： To investigate the clinical efficacy of combining auricular and routine acupuncture for peripheral facial paralysis in acute stage. Methods： A total of 60 eligible cases were randomly allocated into a treatment group （n=30） and a control group （n=30）. Cases in treatment group received auricular and routine acupuncture, whereas cases in the control group received routine acupuncture alone. Both groups were treated for 10 d. Results： The recovery rate was 73.3% in the treatment group and 53.3% in the control group, showing a statistical difference （P〈0.05）. Conclusion： Combining auricular and routine acupuncture is effective for peripheral facial paralysis in acute stage and has a better effect than routine acupuncture.

Efficacy observation of auricular point sticking in combination with a healthy diet for simple obesity in children

Objective To observe the clinical efficacy of combining auricular point sticking and a healthy diet to treat simple obesity in children aged 6–9 years old.Methods A total of 190 eligible obese kids were divided into an observation group and a control group using the random number table method,with 95 cases in each group.The observation group was intervened by auricular point sticking plus guide on a healthy diet,while the control group was only provided with the guide on a healthy diet.The therapeutic efficacy was observed after intervention for three consecutive months,as well as the changes in body mass(BM),body mass index(BMI),waist circumference(WC),hip circumference(HC),and subcutaneous fat thickness.Results After the 3-month intervention,the total effective rate was 91.6%in the observation group,versus 74.7%in the control group,and the between-group difference was statistically significant(P<0.01);in both groups,the BM,BMI,WC,HC,and subcutaneous fat thickness all decreased significantly(P<0.05),and were lower in the observation group than in the control group,showing statistical significance(P<0.05).Conclusion Auricular point sticking plus a healthy diet is safe and effective in treating simple obesity in children,producing more significant efficacy than healthy diet intervention alone.

Clinical Observation on Acupuncture plus Auricular Point Sticking in Treating Insomnia

Insomnia is a common sleep disorder and usually affects the patients＇ emotions and work. We applied acupuncture plus auricular point sticking to treat insomnia and reported it as follows.

Effect of combining acupuncture and auricular point sticking on heart rate variability in patients with post-stroke depression

Objective:To investigate the effect of combining acupuncture and auricular point sticking on heart rate variability(HRV)in patients with post-stroke depression(PSD).Methods:A total of 80 cases with PSD were randomized into a treatment group and a control group.The control group was intervened by oral administration of paroxetine hydrochloride,whereas the treatment group received acupuncture plus auricular point sticking base on the same oral administration.The Hamilton depression rating scale(HAMD)and HRV were measured before and after treatment in both groups.Results:The individual and global scores of HAMD significantly dropped after 8 weeks of treatment in both groups(all P〈0.05).In the treatment group,anxiety/somatization factor,sleep disturbance,hopelessness factor,cognition factor and global score were significantly different from those in the control group(all P〈0.05).The 24 h standard deviation of all normal-to-normal R-R interval(SDNN),standard deviation of 5-minute average of normal R-R intervals(SDANN),root mean square of successive differences(RMSSD),percent of differences between adjacent normal R-R intervals 50 ms(PNN50)and high frequency(HF)were increased while low frequency(LF)and LF/HF decreased significantly after 8 weeks of treatment in both groups(P〈0.05).All items in the treatment group were significantly different from those in the control group(all P〈0.05).Conclusion:Combining acupuncture and auricular point sticking can enhance the conventional medical treatment for HRV in patients with PSD.

Treatment of 60 Cases of Intractable Hiccups Following Craniocerebral Surgery by Acupuncture and Auricular Point Sticking

Hiccup is one of the common complications of craniocerebral surgery, and commonly called as ＂Da Ge （打嗝 ）＂. It is usually caused by ascending counterflow of stomach qi. The modem medicine holds that it is caused by hyperkinesia of diaphragm. Most hiccups are temporary; a mild condition can recover without medical treatments, but a severe one can outbreak around the clock or intermittent attack, it can last for several days, and has a strong impact on patients＇ rehabilitation. It was called intractable hiccups lasting over 24 h and didn＇t respond to treatments of tranquilization, spasmolysis and acupoint injection. The authors treated this disease with acupuncture plus auricular point sticking. Now it is summarized as follows.

Clinical study on auricular point sticking plus Western medicine for moderate gastric cancer pain

Objective:To explore the clinical efficacy and mechanism of auricular point sticking plus Western medicine for moderate gastric cancer pain.Methods:A total of 80 patients were selected and divided into an observation group and a control group according to the random number table method,with 40 cases in each group.Patients in the control group received Western medicine treatment,while patients in the observation group received additional auricular point sticking.Both groups were treated for 2 weeks.Numeric rating scale(NRS)and Karnofsky performance status(KPS)were adopted before and after treatment.The total time and times of flare-up pain in 24 h were recorded.The cyclooxygenase-2(COX-2)and tumor necrosis factor-α(TNF-α)levels were detected.The clinical efficacy of both groups was evaluated after treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);after treatment,NRS scores of both groups were significantly lower than those before treatment(both P<0.05),and the score of the observation group was lower than that of the control group(P<0.05);KPS scores of both groups were significantly higher than those before treatment(both P<0.05),and the score of the observation group was higher than that of the control group(P<0.05).After treatment,the total time and flare-up times of pain during 24 h of both groups were significantly reduced(all P<0.05),and those of the observation group were significantly less than those of the control group(both P<0.05).After treatment,the COX-2 and TNF-αlevels of both groups were significantly reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05).Conclusion:The clinical efficacy of auricular point sticking plus Western medicine for moderate gastric cancer pain is valid.This combined treatment can alleviate cancer pain and improve patients'quality of life,which may be related to its ability to reduce COX-2 and TNF-αlevels.

Auricular acupressure as assistant in primary insomnia management: a randomized single-blind controlled clinical trial

Objective: To observe the efficacy and safety of dexzopiclone plus auricular acupressure in intervening primary insomnia. Methods: A total of 72 participants who met the in clusi on criteria were en rolled in a ran domized con trolled trial, with 36 cases allocated to a treatment group and 36 cases allocated to a control group. Both groups were given dexzopiclone as the routine treatment. Patients in the treatment group were given auricular acupressure with Wang Bu Liu Xing (Semen Vaccariae) seeds at the auricular acupoints related to sleep and emotion based on meridian theory, whereas for patients in the control group, the medical plasters with Wang Bu Liu Xing (Semen Vaccariae) seeds were only gently stuck to acupoints unrelated to sleep without stimulation. Patients in both groups were required to visit the hospital once a week for replacing the seeds and plasters. The course of intervention lasted for 8 weeks and the patients were followed up for another 4 weeks. Pittsburgh sleep quality index (PSQI) and Karolinska sleep diary (KSD) were used to evaluate the outcomes. Meanwhile, adverse effects were monitored and recorded. Results: In the enrolled 72 cases, 4 patients (one in the treatment group and three in the control group) reported thirst and a bitter taste, and one case in the control group reported nausea and vomiting. At last, 3 cases in the control group dropped out for adverse reactions, and 69 cases completed the clinical trial. After 8 weeks of treatment, the global scores of PSQI in both treatment and control groups decreased significantly compared with the baseline (both PvO.001). Furthermore, the global score of PSQI in the treatment group was lower than that in the control group (P<0.01). The global scores of PSQI in both groups at the follow-up were significantly different from the baseline (both PvO.001), but insignificantly different compared with the post-treatment results (both P>0.05). According to KSD, both treatment protocols could prolong the total sleep time, shorten sleep-onset latency, improve sleep efficacy and sleep quality significantly, and the changes in the treatment group were more significant. The total effective rate was 88.9% in the treatment group, higher than 81.8% in the control group, though the difference was statistically insignificant (P>0.05). Con elusion: Dexzopicl one plus auricular acupressure is effective and safe for pati ents with primary in somnia both in short and long terms, and it is more effective tha n mono therapy of dexzopicl one.

Therapeutic efficacy observation on auricular point sticking therapy for cardiac syndrome X in women

Objective:To observe the clinical effect of auricular point sticking therapy for cardiac syndrome X(CSX)in women.Methods:A total of 64 patients were randomized into two groups by the random number table,with 32 cases in each group.Patients in the control group received conventional treatment for angina,while patients in the treatment group received auricular point sticking therapy on the basis of conventional treatment.After 8 weeks of treatment,the levels of serum estradiol(E2),nitric oxide(NO)and endothelium-1(ET-1)were compared to evaluate the therapeutic effect.Results:After 8 weeks of treatment,the total effective rate and markedly effective rate in the treatment group were significantly higher than those in the control group,and the between-group comparisons showed statistical significance(both P<0.05).After treatment,the scores of chest pain and tightness in the control group dropped significantly,and the intra-group comparisons showed statistical significance(both P<0.05);the scores of chest pain and tightness,palpitations,weakness and shortness of breath in the treatment group dropped significantly,and the intra-group comparisons showed statistical significance(all P<0.05);there were significant inter-group differences in the scores of chest pain and tightness.After treatment,the intra-group comparisons of E2,NO and ET-1 contents in the control group showed no statistical significance(all P>0.05),while the E2,NO and ET-1 contents in the treatment group changed significantly after treatment and were significantly different from those in the control group(all P<0.05).Conclusion:Auricular point sticking on the basis of conventional treatment was effective for CSX in women,and is worth clinical application.

Clinical Observation on Treatment of Primary Trigeminal Neuralgia by Point Penetrating Injection plus Ear Pressing

Objective： To investigate the therapeutic effect of primary refractory trigeminal neuralgia. Methods： Twenty-eight cases of primary trigeminal neuralgia were treated by point penetrating injection plus ear pressing, controlled by 28 cases treated only by acupuncture, Results： The total effective rate was 96,43% in observation group and 78.57% in control group. There wasa significant difference in the total effective rate between the two groups （P〈0.05）. Results： Point penetrating injection plus ear pressing is the effective method in treating primary trigeminal neuralgia.

Observation on the Effect of Auricular Point Sticking for Vomiting Induced by Chemotherapy

Objective： To explore the effect of auricular point sticking in relieving chemotherapy induced vomiting, and to observe its effect on the usage of Ondansetron hydrochlorid injection. Methods： Fifty subjects were randomized into a control group and an observation group. The cases in the control group received Ondansetron hydrochlorid injection （i.v.） prior to chemotherapy; while those in the observation group received additional auricular point sticking a day before chemotherapy till the end of the chemotherapy. Results： The dose of Ondansetron hydrochlorid used in the observation group was significantly lower than that in the control （P〈0.05）. Conclusion： Auricular point sticking can reduce the dose of Ondansetron hydrochlorid in the patients with chemotherapy induced vomiting, and effectively attenuate vomiting.

Clinical Observations on the Treatment of Migraine by Acupuncture plus Auricular Plaster Therapy

Objective： To investigate the clinical efficacy of acupuncture plus auricular plaster therapy for treating migraine. Methods： One hundred and fifty migraine patients were randomly allocated to an observation group （n=90） and a control group （n=60）. The observation group were treated by acupuncture plus auricular plaster therapy based on syndrome differentiation and the control group, by oral administration of Flunarizine. The curative effects were compared between the two groups. Results： The total efficacy rate was 94.4% in the observation group and higher than in the control group （73.3%）. The recovery rate was 87.8% in the observation group and higher than in the control group （55.0%）. There were significant differences between the two groups （both P〈0.01）. The curative effect was significantly better in the observation group than in the control group. Conclusion： Clinically, acupuncture plus auricular plaster therapy based on syndrome differentiation has a good effect on migraine.

Effect of Auricular Point Sticking on Pain Due to Lumbar Strain

Objective： To observe the effect of auricular point sticking on pain due to lumbar strain. Methods： Sixty patients with lumbar strain were randomized at ratio of 1：1 into two groups. The 30 cases in the observation group were given auricular point sticking plus externally applied medicinal plaster; the other 30 cases in a control group were only treated by the plaster. The Short-form of McGill Pain Questionnaire （SFMPQ） was adopted before treatment, after 3-day treatment, and at the end of 2-week treatment, for scoring and evaluation. Results： After 3-day treatment, the observation group gained significant improvement in Pain Rating Index （PRI）, Visual Analogue Scale （VAS）, and Present Pain Intensity （PPI） （P〈0.05）, while the improvements of PRI, VAS, and PPI in the control group were insignificant. After 2-week treatment, both groups gained significant progress in PRI, VAS, AND PPI compared with pre-treatment （P〈0.01）, and the inter-group comparison of PRI showed marked difference （P〈0.05）, but the differences in comparing VAS and PPI between the two groups were insignificant. There were merely any side effects happening in the two groups, except that some patients felt itchy, and the inter-group comparison did not show statistical significance. Conclusion： Auricular point sticking plus externally applied medicinal plaster has better effect than single plaster in treating lumbar strain induced pain, and it＇s safe and credible.

Clinical Observation on Simple Obesity Treated by Acupuncture plus Ear Point-Sticking Method

Objective： In order to observe the clinical therapeutic effect of acupuncture plus ear point-sticking for simple obesity. Methods： Fifty-two cases of the patients with simple obesity were treated by acupuncture and ear point-sticking method for one course. Results： After the treatments, the results showed remarkable effect in 22 cases, effect in 25 cases and failure in 5 cases, and the total effective rate was 90.4%. There was no obvious change in various indexes of the body in the male and female patients before and after the treatment. Conclusion： Acupuncture plus ear point-sticking for simple obesity is stable in the therapeutic effect, simple and safe in application, without side effects, and cheap in cost and needs to be greatly popularized

Clinical Study on Acupuncture plus Auricular Point Sticking for Insomnia

Objective： To study the clinical efficacy of acupuncture plus ear-points pressure for insomnia. Method： All 156 cases were randomized into the observation, acupuncture and Chinese herbal formula groups. Combined acupuncture and ear-points pressure, acupuncture alone and Chinese herbal formula were applied in each group respectively. Result： The total effective rates of the observation, acupuncture and herbal group were 94.2%, 75.0% and 78.8% respectively. This has indicated that combined acupuncture and Auricular Point Sticking could obtain significantly better effect than the acupuncture group （P〈0.01） and the herbal group （P〈0.05）. Conclusion： Combined acupuncture and ear-point pressure can obtain a better effect for treatment of insomnia.

Effects of auricular point sticking on dry eye in myopia patients after SMILE surgery:a prospective randomized controlled clinical trial

Objective:To observe the intervention effect of auricular point sticking on dry eye in myopia patients after small-incision lenticule extraction(SMILE)surgery.Methods:This was a prospective randomized controlled study conducted among the myopia patients who received SMILE surgery at Eye and ENT Hospital of Fudan University.The post-SMILE operation patients who screened by the inclusion and exclusion criteria were randomized into a control group and a treatment group.Patients in the control group were given 0.1%fluorometholone and 0.5%carboxymethylcellulose sodium eye drops,while the treatment group was given additional unilateral auricular point sticking for 1 month.The patients were estimated using ocular surface disease index(OSDI),Schirmer tear test-1(STT-1),tear film break-up time(TF-BUT),corneal fluorescein staining(CFS)score,corneal sensitivity(CS)and visual quality(VQ)at 1 d,1 week and 1 month after surgery;the changes in anxiety and depression were also observed in the patients.Results:Compared with the first day after operation,CS in the nasal region was improved in the treatment group,and the VQ score increased in the control group patients at 1 week after operation(both P<0.05);at 1 month after operation,the TF-BUT increased,CFS score decreased,CS in the central and nasal regions increased(all P<0.05),and VQ score increased(P<0.01)in the treatment group,and the CS in the central,upper,lower and nasal regions were improved(all P<0.05),and VQ score increased(P<0.01)in the control group.The between-group comparison showed that the differences in the change of TF-BUT were statistically significant at 1 week and 1 month after surgery,respectively(both P<0.05).Conclusion:Auricular point sticking therapy can increase the TF-BUT and accelerate the repair of ocular surface function in post-SMILE patients.