In this paper,the dynamical evolutions of two types of Arctic Oscillation (AO),the stratospheric (S) and tropospheric (T) types,have been investigated on an intermediate time scale in terms of transient eddy feedback ...In this paper,the dynamical evolutions of two types of Arctic Oscillation (AO),the stratospheric (S) and tropospheric (T) types,have been investigated on an intermediate time scale in terms of transient eddy feedback forcing and three-dimensional Rossby wave propagation.S-Type (T-type) events are characterized by an anomalous stratospheric polar vortex that is in phase (out of phase) with its tropospheric counterpart.Approximately onethird of AO events,both positive and negative,are T-type events.For the positive phase of a T-type event,the formation and maintenance of stratospheric positive anomalies over the polar cap are associated with an upward propagation of Rossby wave packets originating from the near-tropopause altitude over northeastern Asia.However,such upward propagating features are not found for S-type events.In the troposphere,transient eddy feedback forcing is primarily responsible for the meridional seesaw structure of both the S-and T-type events,with an additional contribution from Rossby wave propagation.展开更多
P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on late...P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism (CSM) to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.展开更多
We investigate the low-temperature statistical properties of a harmonic oscillator coupled to a heat bath, where the low-frequency spectrum vanishes. We obtain the exact result of the zero point energy. Due to the low...We investigate the low-temperature statistical properties of a harmonic oscillator coupled to a heat bath, where the low-frequency spectrum vanishes. We obtain the exact result of the zero point energy. Due to the low frequency shortage of environmental oscillators' spectral density, the coordinate and momentum correlation functions decay as T^-4 arid T^-6 respectively at zero temperature, where T is the correlation time. The low-temperature behavior of the mean energy does not violate the third law of thermodynamics, but differs largely from the Ohmic spectrum case.展开更多
This paper considers the uplink of a cooperative Code-Division Multiple-Access (CDMA) system where parts of mobile nodes serve as source nodes while the others serve as relay nodes at any instant in time. When the non...This paper considers the uplink of a cooperative Code-Division Multiple-Access (CDMA) system where parts of mobile nodes serve as source nodes while the others serve as relay nodes at any instant in time. When the non-orthogonal spreading codes are adopted,Multiple Access Interference (MAI) will exist at both the relay nodes and the base node,causing diversity gain to diminish. To mitigate MAI and exploit full advantages of cooperation,the Probabilistic Data Association (PDA) is developed at the relay nodes and the base node. Simulation results demonstrate that some performance gains can be obtained by the PDA detector over the Minimum Mean Square Error (MMSE) detector at high Signal-to-Noise Ratio (SNR) and conversely at low SNR.展开更多
The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in v...The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in vivo functions of protein-polymer conjugates has not been well elucidated. Herein we report the effect of molecular weight of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) on the in vitro and in vivo properties of C-termi- nal interferon-alpha (IFN)-POEGMA conjugates. Increasing the molecular weight of POEGMA decreased the in vitro activity of IFN-ct but increased its thermal stability and in vivo pharmacokinetics. Intriguingly, the in vivo antitumor efficacy of IFN-a was increased by increasing the POEGMA molecular weight from ca. 20 to 60 kDa, but was not further increased by increasing the molecular weight of POEGMA from ca. 60 to 100 kDa due to the neutralization of the improved pharmacokinetics and the reduced in vitro activity. This finding offers a new viewpoint on the molecular size rationale for designing next-generation protein-polymer conjugates, which may benefit patients by reducing admin- istration frequency and adverse reactions, and improving therapeutic efficacy.展开更多
基金supported by the National Basic Research Program of China (973 Program) under Grant 2009CB421406the National Key Technologies R & D Programof China under Grant 2009BAC51B02
文摘In this paper,the dynamical evolutions of two types of Arctic Oscillation (AO),the stratospheric (S) and tropospheric (T) types,have been investigated on an intermediate time scale in terms of transient eddy feedback forcing and three-dimensional Rossby wave propagation.S-Type (T-type) events are characterized by an anomalous stratospheric polar vortex that is in phase (out of phase) with its tropospheric counterpart.Approximately onethird of AO events,both positive and negative,are T-type events.For the positive phase of a T-type event,the formation and maintenance of stratospheric positive anomalies over the polar cap are associated with an upward propagation of Rossby wave packets originating from the near-tropopause altitude over northeastern Asia.However,such upward propagating features are not found for S-type events.In the troposphere,transient eddy feedback forcing is primarily responsible for the meridional seesaw structure of both the S-and T-type events,with an additional contribution from Rossby wave propagation.
基金the National Natural Science Foundation of China (Nos. 60533090 and 60525108)the National Basic research Program (973) of China (No. 2002CB312101)+2 种基金the China-US Million Book Digital Library Project (www.cadal.zju.edu.cn)the Science and Technology Project of Zhejiang Province (Nos. 2005C13032 and 2005C11001-05)the Research Project of Education Department of Zhejiang Province (No. 20061352), China
文摘P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism (CSM) to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.
文摘We investigate the low-temperature statistical properties of a harmonic oscillator coupled to a heat bath, where the low-frequency spectrum vanishes. We obtain the exact result of the zero point energy. Due to the low frequency shortage of environmental oscillators' spectral density, the coordinate and momentum correlation functions decay as T^-4 arid T^-6 respectively at zero temperature, where T is the correlation time. The low-temperature behavior of the mean energy does not violate the third law of thermodynamics, but differs largely from the Ohmic spectrum case.
基金Supported by the National Natural Science Foundation of China (No. 60772061)Science Foundation of Nanjing University of Posts and Telecommunications (No. NY207132)the Postdoctoral Research Programs (No. 0801054B)
文摘This paper considers the uplink of a cooperative Code-Division Multiple-Access (CDMA) system where parts of mobile nodes serve as source nodes while the others serve as relay nodes at any instant in time. When the non-orthogonal spreading codes are adopted,Multiple Access Interference (MAI) will exist at both the relay nodes and the base node,causing diversity gain to diminish. To mitigate MAI and exploit full advantages of cooperation,the Probabilistic Data Association (PDA) is developed at the relay nodes and the base node. Simulation results demonstrate that some performance gains can be obtained by the PDA detector over the Minimum Mean Square Error (MMSE) detector at high Signal-to-Noise Ratio (SNR) and conversely at low SNR.
基金financially supported by Grants from the National Natural Science Foundation of China (21274043 and 21534006).
文摘The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in vivo functions of protein-polymer conjugates has not been well elucidated. Herein we report the effect of molecular weight of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) on the in vitro and in vivo properties of C-termi- nal interferon-alpha (IFN)-POEGMA conjugates. Increasing the molecular weight of POEGMA decreased the in vitro activity of IFN-ct but increased its thermal stability and in vivo pharmacokinetics. Intriguingly, the in vivo antitumor efficacy of IFN-a was increased by increasing the POEGMA molecular weight from ca. 20 to 60 kDa, but was not further increased by increasing the molecular weight of POEGMA from ca. 60 to 100 kDa due to the neutralization of the improved pharmacokinetics and the reduced in vitro activity. This finding offers a new viewpoint on the molecular size rationale for designing next-generation protein-polymer conjugates, which may benefit patients by reducing admin- istration frequency and adverse reactions, and improving therapeutic efficacy.