AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV i...AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV infection genotype 1,under standard combined treatment with pegylated interferon plus ribavirin.One group consisted of 50 patients with sustained virological response,whereas the second group consisted of 49 null responders.In order to analyze the IL28B single nucleotide polymorphisms rs12979860,rs12980275 and rs8099917,samples were used for polymerase chain reaction amplification,and the genotyping was performed by restriction fragment lengthpolymorphism.RESULTS:The IL28B rs12979860 CC,rs12980275 AA and rs8099917 TT genotypes were much more frequently found in patients with sustained virological response compared to null responders 38%,44% and 50% vs 2%,8.2% and 8.2%,respectively.These differences were highly significant in all three cases(P < 0.0001.CONCLUSION:The three IL28B polymorphisms studied are strongly associated with sustained virological response to therapy in Chilean patients with chronic CV genotype 1.展开更多
A novel approach is proposed to automatically detect pomographic images with skin-like color background on the Intemet using the locations of human faces and bodies. It has two separate skin-color detection steps： th...A novel approach is proposed to automatically detect pomographic images with skin-like color background on the Intemet using the locations of human faces and bodies. It has two separate skin-color detection steps： the first one is to quickly detect the potential human skin-color regions; and the second one is to use an off-the-shelf face detector to locate a human face and then apply hypothesis testing based on series of assumptions which take into account the face-height ratio, body orientation and modem photograph composition common sense, etc. After that, a template matching method is used to further discriminate normal images or pornographic ones. Experimental results show that the proposed method has high precision and real time speed.展开更多
基金Supported by The grant OAIC 394/10(to M.V.)from Hospital Clínico Universidad de Chile
文摘AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV infection genotype 1,under standard combined treatment with pegylated interferon plus ribavirin.One group consisted of 50 patients with sustained virological response,whereas the second group consisted of 49 null responders.In order to analyze the IL28B single nucleotide polymorphisms rs12979860,rs12980275 and rs8099917,samples were used for polymerase chain reaction amplification,and the genotyping was performed by restriction fragment lengthpolymorphism.RESULTS:The IL28B rs12979860 CC,rs12980275 AA and rs8099917 TT genotypes were much more frequently found in patients with sustained virological response compared to null responders 38%,44% and 50% vs 2%,8.2% and 8.2%,respectively.These differences were highly significant in all three cases(P < 0.0001.CONCLUSION:The three IL28B polymorphisms studied are strongly associated with sustained virological response to therapy in Chilean patients with chronic CV genotype 1.
文摘A novel approach is proposed to automatically detect pomographic images with skin-like color background on the Intemet using the locations of human faces and bodies. It has two separate skin-color detection steps： the first one is to quickly detect the potential human skin-color regions; and the second one is to use an off-the-shelf face detector to locate a human face and then apply hypothesis testing based on series of assumptions which take into account the face-height ratio, body orientation and modem photograph composition common sense, etc. After that, a template matching method is used to further discriminate normal images or pornographic ones. Experimental results show that the proposed method has high precision and real time speed.
