The present paper reports 9 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese-German Marine Biology Expeditions, in which,Periclimenaeus arabicus(Calman, 1939) andPericl...The present paper reports 9 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese-German Marine Biology Expeditions, in which,Periclimenaeus arabicus(Calman, 1939) andPericlimenaeus hecate(Nobili, 1904) are recorded for the first time from Hainan Island.展开更多
The present paper reports 7 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese German Marine Biology Expeditions, in which, Conchodytes nipponensis (De Haan, 1844) and Co...The present paper reports 7 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese German Marine Biology Expeditions, in which, Conchodytes nipponensis (De Haan, 1844) and Coralliocaris brevirostris Borradaile, 1898 are new records from Chinese waters.展开更多
AIM:To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudineadefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.METHODS:The patient cohort inclu...AIM:To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudineadefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.METHODS:The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy,first with lamivudine(LMV) and then,after developing viral breakthrough,with adefovir(ADV) therapy.All of the patients had non-response or viral breakthrough after LMV-ADV sequential monotherapy,which resulted in the switching of their antiviral regimen to LMV-ADV combination therapy.Eleven serum samples from the four patients who showed non-response to rescue LMV-ADV combination therapy were collected sequentially at a time before the antiviral treatment and then during the LMV monotherapy,ADV monotherapy,and LMV-ADV combination therapy.For the genotypic analysis,the whole 1310-bp polymerase gene region was amplified,cloned and sequenced.RESULTS:All patients had been previously treated with 100 mg of LMV once daily for a 15-to 26-mo period.The emergence of resistance mutations to LMV,such as rtM204V/I and/or rtL180M,were found in all patients.Their antiviral regimens were switched to ADV monotherapy as the second line treatment.All patients had viral breakthrough or non-response after the LMV-ADV sequential monotherapy.ADV-resistant mutations were detected after 13 to 19 mo of LMV-ADV sequential monotherapy.The rtA181V/T mutations were predominantly identified during the ADV treatment in the LMV-resistant patients.Twenty-seven of 38 clones were combined with an amino acid change at rt181;three clones had mutations in rt236 and one clone had a combined mutation.The rtA181V/T mutations were not suppressed by the LMV-ADV combination therapy.Thirty-nine of 64 clones showed an rtA181V/T mutation and six clones showed combined mutations in rt181 and rt236.Mutations in rt204 re-emerged during the combination treatment.The rt181 and rt204 mutations did not co-exist in one clone.CONCLUSION:Add-on lamivudine therapy with adefovir for adefovir resistance may not suppress the pre-existing adefovir-resistant mutation that develops during lamivudine-adefovir sequential monotherapy.展开更多
V-2 technology was transferred from Germany to the Union of Soviet Socialist Republics(USSR)and then on to China.The USSR imitated the captured German V-2 rocket,and independently developed the R-2.Later,China imitate...V-2 technology was transferred from Germany to the Union of Soviet Socialist Republics(USSR)and then on to China.The USSR imitated the captured German V-2 rocket,and independently developed the R-2.Later,China imitated the R-2 rocket provided by the USSR,and independently developed the Dong Feng-2(DF-2).The imitation or localization of foreign products is a key stage prior to independent development.Independent development of new models,in turn,is not only indicative of an upgrading of the transferred technology and the mastering of foreign technology,but also an illustration of innovation.Talent is the crucial resource on which technology transfer relies.The administrative system and domestic collaboration network required to coordinate the necessary tasks,including research,experimentation,design,and manufacture were established both in the USSR and in China.展开更多
This essay is a survey upon Kant＇s Sweet Dream of Perpetual Peace. According to Kant, a permanent peace could be achieved under the condition of the creation of a Federation of States. This Federation of States will ...This essay is a survey upon Kant＇s Sweet Dream of Perpetual Peace. According to Kant, a permanent peace could be achieved under the condition of the creation of a Federation of States. This Federation of States will be rest upon three fundamental requirements--i.e., democracy, reason, universal hospitality. Kant＇s idea of global Federation of States should not be confused with existing nowadays Unions of States, such as European Union, which depend heavily upon a central authority and a complicated bureaucracy.展开更多
In the process of transition from one social order to another, immigrants implement intentional or circumstantial adjustment strategies to position themselves in the new social structure, Within the broad perspective ...In the process of transition from one social order to another, immigrants implement intentional or circumstantial adjustment strategies to position themselves in the new social structure, Within the broad perspective of immigrants＇ incorporation into the receiving society, the present paper focuses on analysis at the micro-level, i,e., bottom-up strategies. These coping strategies define the social positioning of an individual. Through the structure-agency theoretical framework, this article analyses adjustment strategies used by immigrants in order to become members of the receiving society. This is discovered through semi-structured biographical interviews with female immigrants to Germany from former Soviet countries conducted by the author in 2012-2013 in Kaiserslautern. Several positioning strategies emerged in the course of these interviews： ＂destination as a way to a better life＂; ＂trip to joint self＂ which includes ＂identity as a task＂ and change of the behavioral patterns; shift in gender roles; usage of the imported educational capital; work of a ＂stranger next door＂; and social networking, The analysis of immigrants＇ adjustment strategies allows one to see the complexity of the incorporation processes into the receiving society： from essential personality traits such as imagination and aspirations, identity and roles to practically applicable aspects such as education, work, and networking.展开更多
A kind of molecularly imprinted polymer (MIPs) with high selectivity was prepared using methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EDMA) as crosslinker and Gatifloxacin as template. ...A kind of molecularly imprinted polymer (MIPs) with high selectivity was prepared using methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EDMA) as crosslinker and Gatifloxacin as template. The effect of various parameters such as volume of solvent, functional monomer dosage, crosslinker dosage and polymerization time were investigated. The selective binding experiment for substrates show that the affinity and selectivity for Gatifloxacin were higher than that for blank polymer. Scatchard analysis show that the MIPs recognized template with two kinds of binding sites. The dissociation constant Kd and maximum adsorption quantity Qmax of these two kinds of binding sites were calculated: Kd1 and Qmax1 of the binding sites with high affinity were 8.67×10-4 mol/L and 28.19μmol/g, while Kd2 and Qmax2 of the binding sites with low affinity were1.05×10-3 mol/L and 33.20μmol/g respectively.展开更多
AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated cirrhosis.METHODS:Thirty HBeAg positive CHB patients with decompensated cirrhosis ...AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated cirrhosis.METHODS:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the study.All of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic mutation.RESULTS:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after treatment.Serum albumin was also improved at 24 and 48 wk after combination therapy in both groups.The serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination treatment.However,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,respectively.In parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,respectively.Furthermore,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved seroconversion.Child-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk treatment.Moreover,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell counts.CONCLUSION:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.展开更多
Although industrial processes often perform perfectly under design conditions, they may deviate from the optimal operating point owing to parameters drift, environmental disturbances, etc. Thus, it is necessary to dev...Although industrial processes often perform perfectly under design conditions, they may deviate from the optimal operating point owing to parameters drift, environmental disturbances, etc. Thus, it is necessary to develop efficacious strategies or procedure to assess the process performance online. In this paper, we explore the issue of operating optimality assessment for complex industrial processes based on performance-similarity considering nonlinearities and outliers simultaneously, and a general enforced online performance assessment framework is proposed. In the offline part, a new and modified total robust kernel projection to latent structures algorithm,T-KPRM, is proposed and used to evaluate the complex nonlinear industrial process, which can effectively extract the optimal-index-related process variation information from process data and establish assessment models for each performance grades overcoming the effects of outlier. In the online part, the online assessment results can be obtained by calculating the similarity between the online data from a sliding window and each of the performance grades. Furthermore, in order to improve the accuracy of online assessment, we propose an online assessment strategy taking account of the effects of noise and process uncertainties. The Euclidean distance between the sliding data window and the optimal evaluation level is employed to measure the contribution rates of variables, which indicate the possible reason for the non-optimal operating performance. The proposed framework is tested on a real industrial case: dense medium coal preparation process, and the results shows the efficiency of the proposed method comparing to the existing method.展开更多
Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptio...Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptions were employed during the derivation： 1） principal strains by M-C model and D-P model are equal, and 2） the material is under plane strain condition. Based on the analysis of the surface on rt plane, it is found that the proposed D-P type criterion is better than the D-P criterion with M-C circumscribed circle or M-C inscribed circle, and is applicable for stress Lode angle less than zero. By comparing the predicted results with the test data of sand under plane strain condition and other D-P criteria, the proposed criterion is verified and agrees well with the test data, which is further proved to be better than other D--P type criteria in certain range of Lode angle. The criterion was compiled into a finite difference package FLAC3D by user-subroutine, and was used to analyze the stability of a slope by strength reduction method. The predicted slope safety factor from the proposed criterion agrees well with that by Spencer method, and it is more accurate than that from classic D-P criteria.展开更多
This paper summarizes the results of the international questionnaire survey which took place at the start of 2013 in order to examine, judge, and compare the implemented concept and procedures of human resource manage...This paper summarizes the results of the international questionnaire survey which took place at the start of 2013 in order to examine, judge, and compare the implemented concept and procedures of human resource management in the questioned building companies operating in the Visegrad Four countries （the Czech Republic, Hungary, Poland, and the Slovak Republic） and the Federal Republic of Germany, and proposes an optimal approach to human resource management in the context of the current and expected economic development. The questionnaire survey was based on the assumption that effective human resource management is a condition of the successful function of each building company and that human resource management is that area of management which distinguishes the successful building companies from the unsuccessful ones. In total, 202 companies from the Czech Republic, 105 companies from Hungary, 100 companies from Poland, 102 companies from the Slovak Republic, and 99 companies from the Federal Republic of Germany took part in the questionnaire survey. The results of the questionnaire survey showed that among the building companies questioned in individual countries, there was no substantial difference in the overall concept and in the partial procedures of human resource management. The implemented concept and procedures in the questioned building companies show significant merits and surprising shortcomings, whereas it is difficult to prove an unequivocal connection between the efficiency of human resource management and the success of building companies. This relationship is determined by a series of other political, economic, legal, social, cultural, technical, demographic, and natural effects which are not related to the efficiency of human resource management or to the performance of the workforce of building companies.展开更多
文摘The present paper reports 9 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese-German Marine Biology Expeditions, in which,Periclimenaeus arabicus(Calman, 1939) andPericlimenaeus hecate(Nobili, 1904) are recorded for the first time from Hainan Island.
文摘The present paper reports 7 species of pontoniine shrimps collected from Hainan Island, South China Sea, by the Joint Chinese German Marine Biology Expeditions, in which, Conchodytes nipponensis (De Haan, 1844) and Coralliocaris brevirostris Borradaile, 1898 are new records from Chinese waters.
基金Supported by A grant from the South Korea Heathcare Technology R and D Project,Ministry for Health,Welfare and Family Affairs,South Korea,No.A084826
文摘AIM:To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudineadefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.METHODS:The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy,first with lamivudine(LMV) and then,after developing viral breakthrough,with adefovir(ADV) therapy.All of the patients had non-response or viral breakthrough after LMV-ADV sequential monotherapy,which resulted in the switching of their antiviral regimen to LMV-ADV combination therapy.Eleven serum samples from the four patients who showed non-response to rescue LMV-ADV combination therapy were collected sequentially at a time before the antiviral treatment and then during the LMV monotherapy,ADV monotherapy,and LMV-ADV combination therapy.For the genotypic analysis,the whole 1310-bp polymerase gene region was amplified,cloned and sequenced.RESULTS:All patients had been previously treated with 100 mg of LMV once daily for a 15-to 26-mo period.The emergence of resistance mutations to LMV,such as rtM204V/I and/or rtL180M,were found in all patients.Their antiviral regimens were switched to ADV monotherapy as the second line treatment.All patients had viral breakthrough or non-response after the LMV-ADV sequential monotherapy.ADV-resistant mutations were detected after 13 to 19 mo of LMV-ADV sequential monotherapy.The rtA181V/T mutations were predominantly identified during the ADV treatment in the LMV-resistant patients.Twenty-seven of 38 clones were combined with an amino acid change at rt181;three clones had mutations in rt236 and one clone had a combined mutation.The rtA181V/T mutations were not suppressed by the LMV-ADV combination therapy.Thirty-nine of 64 clones showed an rtA181V/T mutation and six clones showed combined mutations in rt181 and rt236.Mutations in rt204 re-emerged during the combination treatment.The rt181 and rt204 mutations did not co-exist in one clone.CONCLUSION:Add-on lamivudine therapy with adefovir for adefovir resistance may not suppress the pre-existing adefovir-resistant mutation that develops during lamivudine-adefovir sequential monotherapy.
基金supported in part by the Youth Innovation Promotion Association CAS(2019157)。
文摘V-2 technology was transferred from Germany to the Union of Soviet Socialist Republics(USSR)and then on to China.The USSR imitated the captured German V-2 rocket,and independently developed the R-2.Later,China imitated the R-2 rocket provided by the USSR,and independently developed the Dong Feng-2(DF-2).The imitation or localization of foreign products is a key stage prior to independent development.Independent development of new models,in turn,is not only indicative of an upgrading of the transferred technology and the mastering of foreign technology,but also an illustration of innovation.Talent is the crucial resource on which technology transfer relies.The administrative system and domestic collaboration network required to coordinate the necessary tasks,including research,experimentation,design,and manufacture were established both in the USSR and in China.
文摘This essay is a survey upon Kant＇s Sweet Dream of Perpetual Peace. According to Kant, a permanent peace could be achieved under the condition of the creation of a Federation of States. This Federation of States will be rest upon three fundamental requirements--i.e., democracy, reason, universal hospitality. Kant＇s idea of global Federation of States should not be confused with existing nowadays Unions of States, such as European Union, which depend heavily upon a central authority and a complicated bureaucracy.
文摘In the process of transition from one social order to another, immigrants implement intentional or circumstantial adjustment strategies to position themselves in the new social structure, Within the broad perspective of immigrants＇ incorporation into the receiving society, the present paper focuses on analysis at the micro-level, i,e., bottom-up strategies. These coping strategies define the social positioning of an individual. Through the structure-agency theoretical framework, this article analyses adjustment strategies used by immigrants in order to become members of the receiving society. This is discovered through semi-structured biographical interviews with female immigrants to Germany from former Soviet countries conducted by the author in 2012-2013 in Kaiserslautern. Several positioning strategies emerged in the course of these interviews： ＂destination as a way to a better life＂; ＂trip to joint self＂ which includes ＂identity as a task＂ and change of the behavioral patterns; shift in gender roles; usage of the imported educational capital; work of a ＂stranger next door＂; and social networking, The analysis of immigrants＇ adjustment strategies allows one to see the complexity of the incorporation processes into the receiving society： from essential personality traits such as imagination and aspirations, identity and roles to practically applicable aspects such as education, work, and networking.
基金China National Science Foundation (No. 20877036)Jiangsu University Science Research Funding (No. 04JDG017).
文摘A kind of molecularly imprinted polymer (MIPs) with high selectivity was prepared using methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EDMA) as crosslinker and Gatifloxacin as template. The effect of various parameters such as volume of solvent, functional monomer dosage, crosslinker dosage and polymerization time were investigated. The selective binding experiment for substrates show that the affinity and selectivity for Gatifloxacin were higher than that for blank polymer. Scatchard analysis show that the MIPs recognized template with two kinds of binding sites. The dissociation constant Kd and maximum adsorption quantity Qmax of these two kinds of binding sites were calculated: Kd1 and Qmax1 of the binding sites with high affinity were 8.67×10-4 mol/L and 28.19μmol/g, while Kd2 and Qmax2 of the binding sites with low affinity were1.05×10-3 mol/L and 33.20μmol/g respectively.
基金Supported by Glorious Funds from Chinese foundation for hepatitis prevention and control,No.GHF2010205
文摘AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated cirrhosis.METHODS:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the study.All of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic mutation.RESULTS:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after treatment.Serum albumin was also improved at 24 and 48 wk after combination therapy in both groups.The serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination treatment.However,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,respectively.In parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,respectively.Furthermore,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved seroconversion.Child-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk treatment.Moreover,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell counts.CONCLUSION:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.
基金Supported by the National Natural Science Foundation of China(61503384,61603393)Natural Science Foundation of Jiangsu(BK20150199,BK20160275)+1 种基金the Foundation Research Funds for the Central Universities(2015QNA65)the Postdoctoral Foundation of Jiangsu Province(1501081B)
文摘Although industrial processes often perform perfectly under design conditions, they may deviate from the optimal operating point owing to parameters drift, environmental disturbances, etc. Thus, it is necessary to develop efficacious strategies or procedure to assess the process performance online. In this paper, we explore the issue of operating optimality assessment for complex industrial processes based on performance-similarity considering nonlinearities and outliers simultaneously, and a general enforced online performance assessment framework is proposed. In the offline part, a new and modified total robust kernel projection to latent structures algorithm,T-KPRM, is proposed and used to evaluate the complex nonlinear industrial process, which can effectively extract the optimal-index-related process variation information from process data and establish assessment models for each performance grades overcoming the effects of outlier. In the online part, the online assessment results can be obtained by calculating the similarity between the online data from a sliding window and each of the performance grades. Furthermore, in order to improve the accuracy of online assessment, we propose an online assessment strategy taking account of the effects of noise and process uncertainties. The Euclidean distance between the sliding data window and the optimal evaluation level is employed to measure the contribution rates of variables, which indicate the possible reason for the non-optimal operating performance. The proposed framework is tested on a real industrial case: dense medium coal preparation process, and the results shows the efficiency of the proposed method comparing to the existing method.
基金Project(2010B14814) supported by the Fundamental Research Funds for the Central Universities of ChinaProject(200801133) supported by the Ministry of Water Resources of China for Public Welfare ProfessionProject(50809023) supported by the National Natural Science Foundation of China
文摘Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptions were employed during the derivation： 1） principal strains by M-C model and D-P model are equal, and 2） the material is under plane strain condition. Based on the analysis of the surface on rt plane, it is found that the proposed D-P type criterion is better than the D-P criterion with M-C circumscribed circle or M-C inscribed circle, and is applicable for stress Lode angle less than zero. By comparing the predicted results with the test data of sand under plane strain condition and other D-P criteria, the proposed criterion is verified and agrees well with the test data, which is further proved to be better than other D--P type criteria in certain range of Lode angle. The criterion was compiled into a finite difference package FLAC3D by user-subroutine, and was used to analyze the stability of a slope by strength reduction method. The predicted slope safety factor from the proposed criterion agrees well with that by Spencer method, and it is more accurate than that from classic D-P criteria.
文摘This paper summarizes the results of the international questionnaire survey which took place at the start of 2013 in order to examine, judge, and compare the implemented concept and procedures of human resource management in the questioned building companies operating in the Visegrad Four countries （the Czech Republic, Hungary, Poland, and the Slovak Republic） and the Federal Republic of Germany, and proposes an optimal approach to human resource management in the context of the current and expected economic development. The questionnaire survey was based on the assumption that effective human resource management is a condition of the successful function of each building company and that human resource management is that area of management which distinguishes the successful building companies from the unsuccessful ones. In total, 202 companies from the Czech Republic, 105 companies from Hungary, 100 companies from Poland, 102 companies from the Slovak Republic, and 99 companies from the Federal Republic of Germany took part in the questionnaire survey. The results of the questionnaire survey showed that among the building companies questioned in individual countries, there was no substantial difference in the overall concept and in the partial procedures of human resource management. The implemented concept and procedures in the questioned building companies show significant merits and surprising shortcomings, whereas it is difficult to prove an unequivocal connection between the efficiency of human resource management and the success of building companies. This relationship is determined by a series of other political, economic, legal, social, cultural, technical, demographic, and natural effects which are not related to the efficiency of human resource management or to the performance of the workforce of building companies.
