Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches ab...Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches about trust mechanism for Internet of Things (IoT) could be found in the literature, though we argue that considerable necessity is held for applying trust mechanism to IoT. In this paper, we establish a formal trust management control mechanism based on architecture modeling of IoT. We decompose the IoT into three layers, which are sensor layer, core layer and application layer, from aspects of network composition of loT. Each layer is controlled by trust management for special purpose: self-organized, affective routing and multi-service respectively. And the final decision-making is performed by service requester according to the collected trust information as well as requester' policy. Finally, we use a formal semantics-based and fuzzy set theory to realize all above trust mechanism, the result of which provides a general framework for the development of trust models of IoT.展开更多
An open architecture for converged Internet of Things (IoT) is proposed in this paper.By using this model,the various and huge amount of data can be converted into converged data and then encapsulated as service packa...An open architecture for converged Internet of Things (IoT) is proposed in this paper.By using this model,the various and huge amount of data can be converted into converged data and then encapsulated as service packages.Moreover,a Representational State Transfer (REST) platform has been implemented in the lab environment.The merit of this architecture is the enhancement of data efficiency.Experimental results are provided to show the benefits of the proposed architecture.展开更多
A future smart grid must fulfill the vision of the Energy Internet in which millions of people produce their own energy from renewables in their homes, offices, and factories and share it with each other. Electric veh...A future smart grid must fulfill the vision of the Energy Internet in which millions of people produce their own energy from renewables in their homes, offices, and factories and share it with each other. Electric vehicles and local energy storage will be widely deployed. Internet technology will be utilized to transform the power grid into an energysharing inter-grid. To prepare for the future, a smart grid with intelligent periphery, or smart GRIP, is proposed. The building blocks of GRIP architecture are called clusters and include an energy-management system (EMS)-controlled transmission grid in the core and distribution grids, micro-grids, and smart buildings and homes on the periphery; all of which are hierarchically structured. The layered architecture of GRIP allows a seamless transition from the present to the future and plug-and-play interoperability. The basic functions of a cluster consist of (1) dispatch, (2) smoothing, and (3) mitigation. A risk-limiting dispatch methodology is presented; a new device, called the electric spring, is developed for smoothing out fluctuations in periphery clusters; and means to mitigate failures are discussed.展开更多
To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-c...To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-coding sequences of mRNAs in five eukaryotic species.The native sequences forming rG4s were then compared with randomized sequences to evaluate selection on synonymous codons.Factors that may influence the formation of rG4 were also investigated,and the selection pressures of rG4 in different gene regions were compared to explore its potential roles in gene regulation.The results show universal selective pressure acts on synonymous codons in rG4 regions to facilitate rG4 formation in five eukaryotic organisms.While G-rich codon combinations are preferred in the rG4 structural region,C-rich codon combinations are selectively unfavorable for rG4 formation.Gene's codon usage bias,nucleotide composition,and evolutionary rate can account for the selective variations on synonymous codons among rG4 structures within a species.Moreover,rG4 structures in the translational initiation region showed significantly higher selective pressures than those in the translational elongation region.展开更多
The wide variety of smart embedded computing devices and their increasing number of applications in our daily life have created new op- portunities to acquire knowledge from the physical world anytime and anywhere, wh...The wide variety of smart embedded computing devices and their increasing number of applications in our daily life have created new op- portunities to acquire knowledge from the physical world anytime and anywhere, which is envisioned as the"Internet of Things" (IoT). Since a huge number of heterogeneous resources are brought in- to IoT, one of the main challenges is how to effi- ciently manage the increasing complexity of IoT in a scalable, flexNle, and autonomic way. Further- more, the emerging IoT applications will require collaborations among loosely coupled devices, which may reside in various locations of the Inter- net. In this paper, we propose a new IoT network management architecture based on cognitive net- work management technology and Service-Orien- ted Architecture to provide effective and efficient network management of loT.展开更多
In Internet of Things(IoT), the devices or terminals are connected with each other, which can be very diverse over the wireless networks. Unfortunately, the current devices are not designed to communicate with the col...In Internet of Things(IoT), the devices or terminals are connected with each other, which can be very diverse over the wireless networks. Unfortunately, the current devices are not designed to communicate with the collocated devices which employ different communication technologies. Consequently, the communication between these devices will be realized only by using the gateway nodes. This will cause the inefficient use of wireless resources. Therefore, in this paper, a smart service system(SSS) architecture is proposed, which consists of smart service terminal(SST), and smart service network(SSN), to realize the Io T in a general environment with diverse communication networks, devices, and services. The proposed architecture has the following advantages: i) the devices in this architecture cover multiple types of terminals and sensor-actuator devices; ii) the communications network therein is a converged network, and will coordinate multiple kinds of existing and emerging networks. This converged network offers ubiquitous access for various sensors and terminals; iii) the architecture has services and applications covering all smart service areas. It also provides theadaptability to new services and applications. A SSS architecture-based smart campus system was developed and deployed. Evaluation experiments of the proposed smart campus system demonstrate the SSS's advantages over the existing counterparts, and verify the effectiveness of the proposed architecture.展开更多
A trinudear Mn(II) coordination complex Mna (HEDTA)2-10H20 (EDTA=ethylene diamine tetraacetic acid) 1 has been synthesized and characterized by X-ray crystal structure determination. In addition, IR spectrum, th...A trinudear Mn(II) coordination complex Mna (HEDTA)2-10H20 (EDTA=ethylene diamine tetraacetic acid) 1 has been synthesized and characterized by X-ray crystal structure determination. In addition, IR spectrum, thermogravimetric analysis, electron paramagnetic resonance (EPR) spectra and magnetic susceptibility of this complex are discussed. X-ray determination indicates that six- and seven-coordinate modes between Mn(Yl) and H4EDTA exist alternately in 1. Furthermore, detailed discussion of magnetic ordering in tile temperature range of 2-300 K reveals the antiferromagnetic interactions in the complex.展开更多
The title compound {Cu2(pdc)2(4,4?-bipy)(H2O)3H2O}2 1 (H2pdc = pyridine-2,6- dicarboxylic acid, also known as dipicolinic acid; 4,4?-bipy = 4,4?-bipyridine) has been synthesized by the hydrothermal reaction and its st...The title compound {Cu2(pdc)2(4,4?-bipy)(H2O)3H2O}2 1 (H2pdc = pyridine-2,6- dicarboxylic acid, also known as dipicolinic acid; 4,4?-bipy = 4,4?-bipyridine) has been synthesized by the hydrothermal reaction and its structure was determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pi with a = 7.2278(3), b = 10.6259(4), c = 17.7614(6) ? a = 79.5990(10), = 83.6300(10), ? = 71.8280(10)o, V = 1272.60(8) ?, C48H44Cu4N8O24, Mr = 1371.07, Z = 1, Dc = 1.789 g/cm3, = 1.747 mm-1, F(000) = 696, R = 0.0397 and wR = 0.1137 for 3938 observed reflections (I > 2s(I)). There are two kinds of Cu coordination environments, and each central copper(II) atom is five-coordinated in a distorted square-based pyramidal coordination geo- metry. Four copper(II) atoms are linked by four pdc and two 4,4?-bipy ligands to form an annular rectangle structure. Extensive hydrogen-bonding interactions involving carboxylate O atoms as well as coordinated and free water molecules lead to the formation of a three-dimensional network struc- ture.展开更多
World Wide Web (WWW) is a vast repository of information, including a great deal of geographic information. But the location and retrieval of geographic information will require a significant amount of time and effort...World Wide Web (WWW) is a vast repository of information, including a great deal of geographic information. But the location and retrieval of geographic information will require a significant amount of time and effort. In addition, different users usually have different views and interests in the same information. To resolve such problems, this paper first proposed a model of geographic information gathering based on multi-Agent (MA) architecture. Then based on this model, we construct a prototype system with GML (Geography Markup Language). This system consists of three tiers-Client, Web Server and Data Resource. Finally, we expatiate on the process of Web Server.展开更多
Crystal structure of pyridine-2,6-dicarboxylate(dipc) vanadium complex:[(dipc)VO_2]_2( 4, 4'-bipyridine)·4H_2O(M_r=724.34) is monoclinic with space group C2/c and a=25.857(8),b=6.896(1),c=16.267(5),β=106.27(...Crystal structure of pyridine-2,6-dicarboxylate(dipc) vanadium complex:[(dipc)VO_2]_2( 4, 4'-bipyridine)·4H_2O(M_r=724.34) is monoclinic with space group C2/c and a=25.857(8),b=6.896(1),c=16.267(5),β=106.27(4)°,V=2784.62 D_c=1.73 g/cm ̄3,F(000)=1472,Z=4.The structural solutions and refinements based on 1661 reflections (I>2σ(I))converged at R=0. 043.The coordinated number of vanadium atom is 5,the geometrical form of the five atoms are coordinated to the vanadium atom is a distorted tetragonal bipyramid of which the four coordinated atoms O(3),O(5),N(1) and O(2) make up the equatorial plane,while the other coordinated atom O(1) is to occupy the apex.展开更多
The crystal structure of the title compound N,N-bisphenyl-3,6-diethyl-1,4- dihydro-s-tetrazine-1,4-dicarbonamide (C20H22N6O2, Mr = 378.44) has been prepared and determi- ned by single-crystal X-ray diffraction. The cr...The crystal structure of the title compound N,N-bisphenyl-3,6-diethyl-1,4- dihydro-s-tetrazine-1,4-dicarbonamide (C20H22N6O2, Mr = 378.44) has been prepared and determi- ned by single-crystal X-ray diffraction. The crystal is of orthorhombic, space group Pbca with a = 16.287(2), b = 11.347(4), c = 20.975(4) ? V = 3876.4(16) ?, Z = 8, Dc = 1.297 g/cm3, F(000) = 1600, m = 0.088 mm-1, MoKa radiation (l = 0.71073 ?. The structure was refined to R = 0.0337 and wR = 0.1038 for 1952 observed reflections with I > 2s(I). X-ray diffraction analysis reveals that two amide groups are located at the 1 and 4 positions, and the tetrazine ring itself shows a boat conformation.展开更多
The vitamin D receptor (VDR) gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore th...The vitamin D receptor (VDR) gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis (PTB). Methods: A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science (Version 13.0) and Review Manager (Version 4.2, The Cochrane Collaboration) were used to analyze the data reported in studies. Results: A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility (allele f vs F: OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF: OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff+FF: OR=1.39, 95%CI=[1.12, 1.71]). No significant associations were observed between TaqI (15 studies with 3 031 cases and 3 132 controls), ApaI (7 studies with 1 495 cases and 1 922 controls), BsmI (6 studies with 919 cases and 1 250 controls) variants and PTB susceptibility. Conclusion: We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.展开更多
The binuclear complex [Ag2(m-Ph2PNHPPh2)3](ClO4)2CH2Cl2CH3OH (Ph2PNHP- Ph2 = bis(diphenylphosphino)amine) was prepared from the reaction of AgClO4 with bis- (diphenylphosphino)amine in equimolar ratio through self-ass...The binuclear complex [Ag2(m-Ph2PNHPPh2)3](ClO4)2CH2Cl2CH3OH (Ph2PNHP- Ph2 = bis(diphenylphosphino)amine) was prepared from the reaction of AgClO4 with bis- (diphenylphosphino)amine in equimolar ratio through self-assembly. The coordination cation affords a triply-bridging [Ag2L3]-type coordination moiety. The silver atom is in a trigonal planar environment with P3 coordination chromophore. The complex (C74H69Cl4N3O9P6Ag2) crystallizes in monoclinic, space group Cc with a = 18.3738(1), b = 20.0207(4), c = 20.5422(4) ? b = 95.829(1), V = 7517.5(2) 3, Z = 4, Mr = 1687.68, Dc = 1.491 g/cm3, F(000) = 3432, m = 0.848 mm-1, the final R = 0.0460 and wR = 0.0935 for 7005 observed reflections with I > 2s(I).展开更多
New heteroleptic and homoleptic complexes of the type[Pd(4,5-dmbipy)C12], [Pd(4,5-dmbipy)L2], and [Pd(4,5-dimebipy)2]2+ (L = Pyridine or 4-methylpyridine(4-picoline), bipy = 2,2'-bipyridine, and 4,5-dimebip...New heteroleptic and homoleptic complexes of the type[Pd(4,5-dmbipy)C12], [Pd(4,5-dmbipy)L2], and [Pd(4,5-dimebipy)2]2+ (L = Pyridine or 4-methylpyridine(4-picoline), bipy = 2,2'-bipyridine, and 4,5-dimebipy = 4,5-dimethyl-2,2'-bipyridine) were synthesized and characterized by IH NMR and elemental analysis. The crystal structure of bis(4-methylpyridine)-4,5- dimethyl-2,2'-bipyridinepalladium(II)perchlorate [Pd(4,5-dmbipy)(4-pic)2](CIO4)2 was also determined by single crystal X-ray diffraction. This complex crystallized in the triclinic crystal system and space group PI with a = 9.562 (2), b = 11.326 (4), c = 15.0120 (10) A°; α = 70.940°, β= 77.60 (2), γ= 67.86 (2) and z = 4. The Pd (II) in square planar environment showed a small distortion towards tetrahedral through one coordinated bipyridine ring twisting with respect to the other.展开更多
文摘Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches about trust mechanism for Internet of Things (IoT) could be found in the literature, though we argue that considerable necessity is held for applying trust mechanism to IoT. In this paper, we establish a formal trust management control mechanism based on architecture modeling of IoT. We decompose the IoT into three layers, which are sensor layer, core layer and application layer, from aspects of network composition of loT. Each layer is controlled by trust management for special purpose: self-organized, affective routing and multi-service respectively. And the final decision-making is performed by service requester according to the collected trust information as well as requester' policy. Finally, we use a formal semantics-based and fuzzy set theory to realize all above trust mechanism, the result of which provides a general framework for the development of trust models of IoT.
基金supported by the Special Funds for Key Program of the China No.2009ZX01039-002-001-07,No.2010ZX03005-001-03Ministry of Education infrastructure construction project(2-5-2)
文摘An open architecture for converged Internet of Things (IoT) is proposed in this paper.By using this model,the various and huge amount of data can be converted into converged data and then encapsulated as service packages.Moreover,a Representational State Transfer (REST) platform has been implemented in the lab environment.The merit of this architecture is the enhancement of data efficiency.Experimental results are provided to show the benefits of the proposed architecture.
基金sponsored by National Key Basic Research Program of China (973 Program) (2012CB215102) for WuUS National Science Foundation Award (1135872) for VaraiyaHong Kong RGC Theme-based Research Project (T23-701/14-N) for Hui
文摘A future smart grid must fulfill the vision of the Energy Internet in which millions of people produce their own energy from renewables in their homes, offices, and factories and share it with each other. Electric vehicles and local energy storage will be widely deployed. Internet technology will be utilized to transform the power grid into an energysharing inter-grid. To prepare for the future, a smart grid with intelligent periphery, or smart GRIP, is proposed. The building blocks of GRIP architecture are called clusters and include an energy-management system (EMS)-controlled transmission grid in the core and distribution grids, micro-grids, and smart buildings and homes on the periphery; all of which are hierarchically structured. The layered architecture of GRIP allows a seamless transition from the present to the future and plug-and-play interoperability. The basic functions of a cluster consist of (1) dispatch, (2) smoothing, and (3) mitigation. A risk-limiting dispatch methodology is presented; a new device, called the electric spring, is developed for smoothing out fluctuations in periphery clusters; and means to mitigate failures are discussed.
基金The National Key Research and Development Program of China(No.2018YFC1314900,2018YFC1314902)the National Natural Science Foundation of China(No.61571109)the Fundamental Research Funds for the Central Universities(No.2242017K3DN04).
文摘To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-coding sequences of mRNAs in five eukaryotic species.The native sequences forming rG4s were then compared with randomized sequences to evaluate selection on synonymous codons.Factors that may influence the formation of rG4 were also investigated,and the selection pressures of rG4 in different gene regions were compared to explore its potential roles in gene regulation.The results show universal selective pressure acts on synonymous codons in rG4 regions to facilitate rG4 formation in five eukaryotic organisms.While G-rich codon combinations are preferred in the rG4 structural region,C-rich codon combinations are selectively unfavorable for rG4 formation.Gene's codon usage bias,nucleotide composition,and evolutionary rate can account for the selective variations on synonymous codons among rG4 structures within a species.Moreover,rG4 structures in the translational initiation region showed significantly higher selective pressures than those in the translational elongation region.
基金supported by the National Sci.&Tech. Major Project of China(No.2010ZX03004-002)the National Natural Science Foundation of China(No.60972083)
文摘The wide variety of smart embedded computing devices and their increasing number of applications in our daily life have created new op- portunities to acquire knowledge from the physical world anytime and anywhere, which is envisioned as the"Internet of Things" (IoT). Since a huge number of heterogeneous resources are brought in- to IoT, one of the main challenges is how to effi- ciently manage the increasing complexity of IoT in a scalable, flexNle, and autonomic way. Further- more, the emerging IoT applications will require collaborations among loosely coupled devices, which may reside in various locations of the Inter- net. In this paper, we propose a new IoT network management architecture based on cognitive net- work management technology and Service-Orien- ted Architecture to provide effective and efficient network management of loT.
基金supported by the national 973 project of China under Grants 2013CB329104the Natural Science Foundation of China under Grants 61372124, 61427801+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions (Grant No.13KJB520029)the Jiangsu Province colleges and universities graduate students scientific research and innovation program CXZZ13_0477,NUPTSF(Grant No.NY214033)
文摘In Internet of Things(IoT), the devices or terminals are connected with each other, which can be very diverse over the wireless networks. Unfortunately, the current devices are not designed to communicate with the collocated devices which employ different communication technologies. Consequently, the communication between these devices will be realized only by using the gateway nodes. This will cause the inefficient use of wireless resources. Therefore, in this paper, a smart service system(SSS) architecture is proposed, which consists of smart service terminal(SST), and smart service network(SSN), to realize the Io T in a general environment with diverse communication networks, devices, and services. The proposed architecture has the following advantages: i) the devices in this architecture cover multiple types of terminals and sensor-actuator devices; ii) the communications network therein is a converged network, and will coordinate multiple kinds of existing and emerging networks. This converged network offers ubiquitous access for various sensors and terminals; iii) the architecture has services and applications covering all smart service areas. It also provides theadaptability to new services and applications. A SSS architecture-based smart campus system was developed and deployed. Evaluation experiments of the proposed smart campus system demonstrate the SSS's advantages over the existing counterparts, and verify the effectiveness of the proposed architecture.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.20490210,10574047)the Doctor Foundation of China(Grant No.20030487003)
文摘A trinudear Mn(II) coordination complex Mna (HEDTA)2-10H20 (EDTA=ethylene diamine tetraacetic acid) 1 has been synthesized and characterized by X-ray crystal structure determination. In addition, IR spectrum, thermogravimetric analysis, electron paramagnetic resonance (EPR) spectra and magnetic susceptibility of this complex are discussed. X-ray determination indicates that six- and seven-coordinate modes between Mn(Yl) and H4EDTA exist alternately in 1. Furthermore, detailed discussion of magnetic ordering in tile temperature range of 2-300 K reveals the antiferromagnetic interactions in the complex.
基金This work was financially supported by the NNSFC (No. 20173063) the State Key Basic Research and Development Plan of China (001CB108906) and the NSF of Fujian Province (E0020001)
文摘The title compound {Cu2(pdc)2(4,4?-bipy)(H2O)3H2O}2 1 (H2pdc = pyridine-2,6- dicarboxylic acid, also known as dipicolinic acid; 4,4?-bipy = 4,4?-bipyridine) has been synthesized by the hydrothermal reaction and its structure was determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pi with a = 7.2278(3), b = 10.6259(4), c = 17.7614(6) ? a = 79.5990(10), = 83.6300(10), ? = 71.8280(10)o, V = 1272.60(8) ?, C48H44Cu4N8O24, Mr = 1371.07, Z = 1, Dc = 1.789 g/cm3, = 1.747 mm-1, F(000) = 696, R = 0.0397 and wR = 0.1137 for 3938 observed reflections (I > 2s(I)). There are two kinds of Cu coordination environments, and each central copper(II) atom is five-coordinated in a distorted square-based pyramidal coordination geo- metry. Four copper(II) atoms are linked by four pdc and two 4,4?-bipy ligands to form an annular rectangle structure. Extensive hydrogen-bonding interactions involving carboxylate O atoms as well as coordinated and free water molecules lead to the formation of a three-dimensional network struc- ture.
文摘World Wide Web (WWW) is a vast repository of information, including a great deal of geographic information. But the location and retrieval of geographic information will require a significant amount of time and effort. In addition, different users usually have different views and interests in the same information. To resolve such problems, this paper first proposed a model of geographic information gathering based on multi-Agent (MA) architecture. Then based on this model, we construct a prototype system with GML (Geography Markup Language). This system consists of three tiers-Client, Web Server and Data Resource. Finally, we expatiate on the process of Web Server.
文摘Crystal structure of pyridine-2,6-dicarboxylate(dipc) vanadium complex:[(dipc)VO_2]_2( 4, 4'-bipyridine)·4H_2O(M_r=724.34) is monoclinic with space group C2/c and a=25.857(8),b=6.896(1),c=16.267(5),β=106.27(4)°,V=2784.62 D_c=1.73 g/cm ̄3,F(000)=1472,Z=4.The structural solutions and refinements based on 1661 reflections (I>2σ(I))converged at R=0. 043.The coordinated number of vanadium atom is 5,the geometrical form of the five atoms are coordinated to the vanadium atom is a distorted tetragonal bipyramid of which the four coordinated atoms O(3),O(5),N(1) and O(2) make up the equatorial plane,while the other coordinated atom O(1) is to occupy the apex.
基金the NNSFC (No. 20272053) and Science and Technology Bureau (011101937) of Zhejiang province
文摘The crystal structure of the title compound N,N-bisphenyl-3,6-diethyl-1,4- dihydro-s-tetrazine-1,4-dicarbonamide (C20H22N6O2, Mr = 378.44) has been prepared and determi- ned by single-crystal X-ray diffraction. The crystal is of orthorhombic, space group Pbca with a = 16.287(2), b = 11.347(4), c = 20.975(4) ? V = 3876.4(16) ?, Z = 8, Dc = 1.297 g/cm3, F(000) = 1600, m = 0.088 mm-1, MoKa radiation (l = 0.71073 ?. The structure was refined to R = 0.0337 and wR = 0.1038 for 1952 observed reflections with I > 2s(I). X-ray diffraction analysis reveals that two amide groups are located at the 1 and 4 positions, and the tetrazine ring itself shows a boat conformation.
基金Supported by the National Natural Science Foundation of China (30700685)the Medical Science and Technology Research Project of Chongqing Municipal Health Bureau (2009-1-06)
文摘The vitamin D receptor (VDR) gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis (PTB). Methods: A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science (Version 13.0) and Review Manager (Version 4.2, The Cochrane Collaboration) were used to analyze the data reported in studies. Results: A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility (allele f vs F: OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF: OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff+FF: OR=1.39, 95%CI=[1.12, 1.71]). No significant associations were observed between TaqI (15 studies with 3 031 cases and 3 132 controls), ApaI (7 studies with 1 495 cases and 1 922 controls), BsmI (6 studies with 919 cases and 1 250 controls) variants and PTB susceptibility. Conclusion: We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.
基金This work was supported by NNSFC (No. 20171044) and the project for "undred Talents from" the Chinese Academy of Sciences
文摘The binuclear complex [Ag2(m-Ph2PNHPPh2)3](ClO4)2CH2Cl2CH3OH (Ph2PNHP- Ph2 = bis(diphenylphosphino)amine) was prepared from the reaction of AgClO4 with bis- (diphenylphosphino)amine in equimolar ratio through self-assembly. The coordination cation affords a triply-bridging [Ag2L3]-type coordination moiety. The silver atom is in a trigonal planar environment with P3 coordination chromophore. The complex (C74H69Cl4N3O9P6Ag2) crystallizes in monoclinic, space group Cc with a = 18.3738(1), b = 20.0207(4), c = 20.5422(4) ? b = 95.829(1), V = 7517.5(2) 3, Z = 4, Mr = 1687.68, Dc = 1.491 g/cm3, F(000) = 3432, m = 0.848 mm-1, the final R = 0.0460 and wR = 0.0935 for 7005 observed reflections with I > 2s(I).
文摘New heteroleptic and homoleptic complexes of the type[Pd(4,5-dmbipy)C12], [Pd(4,5-dmbipy)L2], and [Pd(4,5-dimebipy)2]2+ (L = Pyridine or 4-methylpyridine(4-picoline), bipy = 2,2'-bipyridine, and 4,5-dimebipy = 4,5-dimethyl-2,2'-bipyridine) were synthesized and characterized by IH NMR and elemental analysis. The crystal structure of bis(4-methylpyridine)-4,5- dimethyl-2,2'-bipyridinepalladium(II)perchlorate [Pd(4,5-dmbipy)(4-pic)2](CIO4)2 was also determined by single crystal X-ray diffraction. This complex crystallized in the triclinic crystal system and space group PI with a = 9.562 (2), b = 11.326 (4), c = 15.0120 (10) A°; α = 70.940°, β= 77.60 (2), γ= 67.86 (2) and z = 4. The Pd (II) in square planar environment showed a small distortion towards tetrahedral through one coordinated bipyridine ring twisting with respect to the other.