一种兽用地美硝唑预混剂的制备及稳定性研究

以地美硝唑为主成分原料,以聚乙二醇6000、倍他环糊精作为主成分的助溶剂,地美硝唑和辅料经过过筛、混合后进行粉碎制得地美硝唑预混剂。该配方的组合为:质量比M(地美硝唑):M(倍他环糊精):M(聚乙二醇6000)=2:2:6。研究表明地美硝唑预混剂的溶解度良好,溶解度可达8.0%;按地美硝唑预混剂的质量标准要求检测,合格。该配方组合可以同时实现药物的饮水和拌料给药。在密闭条件下保存,长期试验2年,产品的性状和外观几乎没有改变;地美硝唑含量从初始的100.1%下降至97.5%,有效成分含量下降幅度未超过地美硝唑标示量百分含量的10%。产品质量稳定,符合兽药典的要求。地美硝唑预混剂的配方合理、生产操作简单,产品24个月质量稳定,有效期可暂定为24个月。

土豆淀粉马来酸酐酯的合成、表征及性能研究

研究了以聚乙二醇、水、乙醇三种不同极性的物质为反应溶剂,土豆淀粉马来酸酐酯的合成过程控制、表征及透明度、冻融稳定性的研究。在聚乙二醇反应体系中,pH=8～8.5,温度为50℃、马来酸酐占淀粉量50%的时,酯化淀粉的取代度最高,可以达到1.8702;随着温度的升高,其取代度反而下降,这说明,在高温度下反应导致酯化过程发生逆反应,而使其取代度降低。通过FTIR、DSC和XRD等现代手段对酯化淀粉进行表征,可以得出其结晶度从59.2%下降到21.18%。而且,酯化淀粉的透明度有了一定的提高,冻融稳定性好。以上性能对成膜的质量有着决定性作用。

Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15K to 333.15K

The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol （IPA）, polyethylene glycol-400 （PEG-400） and β-cyclodextrin （β-CD） aqueous solution （0.02 mol·L^-1 ）. The solubility of diosmio was measured using the shake flask method from （298.15 to 333.15） K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in 5-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol ＆ IPA and soluble in PEG- 400 and β-CD aqueous solution.