Adopting Poly（ethylene glycol） adipate Dilpoly- （ethylene glycol）] adipate polydiglycol adipate glycol （PDAG）, 1,4-butanediol （BDO）, hydroxy silicone oil, methylene diphenyl diisocyanate （MDI） as the raw mat...Adopting Poly（ethylene glycol） adipate Dilpoly- （ethylene glycol）] adipate polydiglycol adipate glycol （PDAG）, 1,4-butanediol （BDO）, hydroxy silicone oil, methylene diphenyl diisocyanate （MDI） as the raw material, a new polyurethane elastic body can be made through prepolymerization. After measurement of the moisture permeability, adsorption quantity and mechanical properties of the membrane made with the elastic body, we also proofed its formula by infrared spectroscopy. The result showed that the moisture permeability of the membrane, with a certain intelligent thermotropic quality, will increase by 3 to 4 times when the temperature is between 25℃-45℃.展开更多
目的:考察乙醇-油酸聚乙二醇甘油酯(labrafil M 1944 CS)和聚氧乙烯氢化蓖麻油40(cremophor RH40)的鼻黏膜毒性,探讨其在鼻腔给药系统中应用的可行性。方法:以山梨糖醇酐油酸酯(span-80)和聚山梨酯-80(tween-80)为参比,采用在体蟾蜍上...目的:考察乙醇-油酸聚乙二醇甘油酯(labrafil M 1944 CS)和聚氧乙烯氢化蓖麻油40(cremophor RH40)的鼻黏膜毒性,探讨其在鼻腔给药系统中应用的可行性。方法:以山梨糖醇酐油酸酯(span-80)和聚山梨酯-80(tween-80)为参比,采用在体蟾蜍上腭模型,光学显微镜下观察纤毛持续运动时间,考察cremophor RH40和labrafil M 1944 CS的纤毛毒性作用;运用家兔血细胞溶血试验,考察cremophor RH40和labrafil M 1944 CS对细胞膜完整性的影响。结果:体积分数为1%时,4种表面活性剂对纤毛运动的影响顺序为cremophor RH40<labrafil M 1944 CS<tween-80<span-80;cremophor RH40的细胞膜毒性最小,tween-80和span-80次之,而labrafil M 1944 CS的影响最大;cremophor RH40对细胞膜完整性无影响用量为tween-80和span-80的15倍。结论:在一定体积分数下cremophor RH40的鼻黏膜毒性作用较小,可应用于鼻腔给药制剂的研制。展开更多
基金Acknowledgments： This work was supported in part by the National Natural Science Foundation of China （No. 20504023）.
文摘Adopting Poly（ethylene glycol） adipate Dilpoly- （ethylene glycol）] adipate polydiglycol adipate glycol （PDAG）, 1,4-butanediol （BDO）, hydroxy silicone oil, methylene diphenyl diisocyanate （MDI） as the raw material, a new polyurethane elastic body can be made through prepolymerization. After measurement of the moisture permeability, adsorption quantity and mechanical properties of the membrane made with the elastic body, we also proofed its formula by infrared spectroscopy. The result showed that the moisture permeability of the membrane, with a certain intelligent thermotropic quality, will increase by 3 to 4 times when the temperature is between 25℃-45℃.
文摘目的:考察乙醇-油酸聚乙二醇甘油酯(labrafil M 1944 CS)和聚氧乙烯氢化蓖麻油40(cremophor RH40)的鼻黏膜毒性,探讨其在鼻腔给药系统中应用的可行性。方法:以山梨糖醇酐油酸酯(span-80)和聚山梨酯-80(tween-80)为参比,采用在体蟾蜍上腭模型,光学显微镜下观察纤毛持续运动时间,考察cremophor RH40和labrafil M 1944 CS的纤毛毒性作用;运用家兔血细胞溶血试验,考察cremophor RH40和labrafil M 1944 CS对细胞膜完整性的影响。结果:体积分数为1%时,4种表面活性剂对纤毛运动的影响顺序为cremophor RH40<labrafil M 1944 CS<tween-80<span-80;cremophor RH40的细胞膜毒性最小,tween-80和span-80次之,而labrafil M 1944 CS的影响最大;cremophor RH40对细胞膜完整性无影响用量为tween-80和span-80的15倍。结论:在一定体积分数下cremophor RH40的鼻黏膜毒性作用较小,可应用于鼻腔给药制剂的研制。
