通过开环聚合(ROP)、DCC偶合反应及原子转移自由基聚合(ATRP)合成3种不同臂数(线性、三臂和六臂)的聚己内酯-b-聚乙二醇-b-聚甲基丙烯酸(2-羟乙酯)(PCL-PEG-PHEMA)三嵌段共聚物。通过核磁氢谱(1 H NMR)红外谱图证明合成了设计产物。以...通过开环聚合(ROP)、DCC偶合反应及原子转移自由基聚合(ATRP)合成3种不同臂数(线性、三臂和六臂)的聚己内酯-b-聚乙二醇-b-聚甲基丙烯酸(2-羟乙酯)(PCL-PEG-PHEMA)三嵌段共聚物。通过核磁氢谱(1 H NMR)红外谱图证明合成了设计产物。以溶剂挥发法制备胶束并进行载药实验。用激光粒度仪测定胶束粒径、粒径分布及zeta电位,用荧光光谱仪以芘荧光探针法测定临界胶束浓度,用紫外-可见分光光度计表征胶束载药量、包封率。结果表明,3种三嵌段共聚物均能形成稳定的载药胶束,其中具有星形结构的六臂的三嵌段共聚物具有最低的胶束粒径和临界胶束浓度、最高的载药量和包封率。因此,星形六臂的PCL-PEG-PHEMA可作为新的药物载体材料。展开更多
Poly(vinyl chloride)-g-poly(2-hydroxyethyl methacrylate) (PVC-g-PHE MA) copolymers were prepared by the aqueous suspension-swelling graft copolymer ization process.The grafting of HEMA on PVC was confirmed by the infr...Poly(vinyl chloride)-g-poly(2-hydroxyethyl methacrylate) (PVC-g-PHE MA) copolymers were prepared by the aqueous suspension-swelling graft copolymer ization process.The grafting of HEMA on PVC was confirmed by the infrared spect rum.The grafting degree increased with the increase of feeding mass fraction of HEMA,and a maximum grafting efficiency appeared at 10% mass fraction of HEMA i n feed.The grafting degree and efficiency increased as partially dehydrochlorin ated PVC was used.The intrinsic viscosity of graft copolymers increased slowly with the increase of the grafting degree of HEMA,and decreased at high grafting degrees.PVC-g-PHEMA copolymers exhibited a higher glass transition tempe rature (T g) in the first DSC run than that in the second run,and T g of graft copolymers increased as the grafting degree increased.展开更多
采用新疆奇台风化煤为原料,通过表面引发原子转移自由基聚合(SI-ATRP)方法制备腐植酸钠-聚甲基丙烯酸甲酯接枝共聚物(HA-Na-PMMA),通过正交实验确定了SI-ATRP最佳合成工艺条件:反应时间8 h,溴化亚铜∶溴化铜∶2,2-联吡啶质量比为20∶4∶...采用新疆奇台风化煤为原料,通过表面引发原子转移自由基聚合(SI-ATRP)方法制备腐植酸钠-聚甲基丙烯酸甲酯接枝共聚物(HA-Na-PMMA),通过正交实验确定了SI-ATRP最佳合成工艺条件:反应时间8 h,溴化亚铜∶溴化铜∶2,2-联吡啶质量比为20∶4∶20,物料质量比∶体积比为1 g∶10 m L,反应温度80℃。通过SI-ATRP制备的HA-Na-PMMA的接触角为84°,比HA-Na的接触角增大了54°,表明HA-Na的SI-ATRP接枝共聚效果显著。以HA-Na-PMMA为吸附剂,研究其对Cr(Ⅵ)的吸附性能,同时建立了HA-Na-PMMA对Cr(Ⅵ)的等温吸附模型,研究了其吸附热力学和吸附动力学。HA-Na-PMMA对Cr(Ⅵ)具有良好的吸附性能,其等温吸附模型符合Freundlich模型。吸附焓变为-0.2849 k J/mol,ΔGθ<0,所以吸附是自发的放热反应。常温下吸附速率常数KL为0.9113 mg/(g·min),表明其吸附动力学模型遵循Langmuir模型和Bingham模型。展开更多
文摘通过开环聚合(ROP)、DCC偶合反应及原子转移自由基聚合(ATRP)合成3种不同臂数(线性、三臂和六臂)的聚己内酯-b-聚乙二醇-b-聚甲基丙烯酸(2-羟乙酯)(PCL-PEG-PHEMA)三嵌段共聚物。通过核磁氢谱(1 H NMR)红外谱图证明合成了设计产物。以溶剂挥发法制备胶束并进行载药实验。用激光粒度仪测定胶束粒径、粒径分布及zeta电位,用荧光光谱仪以芘荧光探针法测定临界胶束浓度,用紫外-可见分光光度计表征胶束载药量、包封率。结果表明,3种三嵌段共聚物均能形成稳定的载药胶束,其中具有星形结构的六臂的三嵌段共聚物具有最低的胶束粒径和临界胶束浓度、最高的载药量和包封率。因此,星形六臂的PCL-PEG-PHEMA可作为新的药物载体材料。
文摘Poly(vinyl chloride)-g-poly(2-hydroxyethyl methacrylate) (PVC-g-PHE MA) copolymers were prepared by the aqueous suspension-swelling graft copolymer ization process.The grafting of HEMA on PVC was confirmed by the infrared spect rum.The grafting degree increased with the increase of feeding mass fraction of HEMA,and a maximum grafting efficiency appeared at 10% mass fraction of HEMA i n feed.The grafting degree and efficiency increased as partially dehydrochlorin ated PVC was used.The intrinsic viscosity of graft copolymers increased slowly with the increase of the grafting degree of HEMA,and decreased at high grafting degrees.PVC-g-PHEMA copolymers exhibited a higher glass transition tempe rature (T g) in the first DSC run than that in the second run,and T g of graft copolymers increased as the grafting degree increased.
文摘采用新疆奇台风化煤为原料,通过表面引发原子转移自由基聚合(SI-ATRP)方法制备腐植酸钠-聚甲基丙烯酸甲酯接枝共聚物(HA-Na-PMMA),通过正交实验确定了SI-ATRP最佳合成工艺条件:反应时间8 h,溴化亚铜∶溴化铜∶2,2-联吡啶质量比为20∶4∶20,物料质量比∶体积比为1 g∶10 m L,反应温度80℃。通过SI-ATRP制备的HA-Na-PMMA的接触角为84°,比HA-Na的接触角增大了54°,表明HA-Na的SI-ATRP接枝共聚效果显著。以HA-Na-PMMA为吸附剂,研究其对Cr(Ⅵ)的吸附性能,同时建立了HA-Na-PMMA对Cr(Ⅵ)的等温吸附模型,研究了其吸附热力学和吸附动力学。HA-Na-PMMA对Cr(Ⅵ)具有良好的吸附性能,其等温吸附模型符合Freundlich模型。吸附焓变为-0.2849 k J/mol,ΔGθ<0,所以吸附是自发的放热反应。常温下吸附速率常数KL为0.9113 mg/(g·min),表明其吸附动力学模型遵循Langmuir模型和Bingham模型。
