Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectro...Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy,transmission electron microscopy and UV spectroscopy.It was found that the hydrophobic inner core of the micelles formed by poly(γbenzyl L-glutamate)(PBLG) segments can act as an incorporation site for hydrophobic drugs.The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases.The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.展开更多
目的 探讨聚乙二醇干扰素α-2a与替诺福韦酯对高病毒载量慢性乙肝初治患者血清单核因子(monokine induced by IFN-γ,Mig)、调节活化正常T细胞表达和分泌的趋化因子(egulated upon activation normal T cell expressed and secreted,RAN...目的 探讨聚乙二醇干扰素α-2a与替诺福韦酯对高病毒载量慢性乙肝初治患者血清单核因子(monokine induced by IFN-γ,Mig)、调节活化正常T细胞表达和分泌的趋化因子(egulated upon activation normal T cell expressed and secreted,RANTES)以及肝纤维化指标表达的影响。方法 对赣州市人民医院2020年5月—2021年5月收治的129例慢性乙肝患者展开回顾性分析,按照治疗方案分组,将使用替诺福韦酯治疗的64例患者归为常规组,将使用聚乙二醇干扰素α-2a与替诺福韦酯联合治疗的65例患者纳入联合组。2组治疗时间均为6个月,治疗后比较2组肝功能指标[总胆红素(total bilirubin,TBIL)、谷丙转氨酶(alanine aminotransferase,ALT)以及谷草转氨酶(aspartate aminotransferase,AST)],对比2组血清Mig、RANTES水平,记录2组肝纤维化指标[层连黏蛋白(laminin,LN)、Ⅲ型前胶原蛋白(procollagen typeⅢ,PCⅢ)、Ⅳ型肽原(CollagenⅣ,Ⅳ-C)、透明质酸酶(hyaluronidase,HA)],观察2组乙肝病毒脱氧核糖核酸(hepatitis B virus deoxyribonucleic acid,HBV-DNA)转阴率与乙型肝炎病毒e抗原(hepatitis B e antigen,HBeAg)转阴率。结果 治疗后,联合组TBIL、ALT以及AST均比常规组低(P<0.05)。治疗后,联合组血清Mig、RANTES水平低于常规组(P<0.05)。治疗后,联合组LN、PCⅢ、Ⅳ-C和HA水平均比常规组低(P<0.05)。联合组HBV-DNA、HBeAg转阴率为分别86.15%、75.38%,高于常规组的65.63%、54.69%(P<0.05)。结论 对高病毒载量慢性乙肝初治患者采用聚乙二醇干扰素α-2a与替诺福韦酯联合治疗,可改善患者肝功能与肝纤维化指标,降低血清Mig、RANTES水平,有效促进HBV-DNA、HBeAg转阴。该方法可作为治疗慢性乙肝的优选方案。展开更多
文摘Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy,transmission electron microscopy and UV spectroscopy.It was found that the hydrophobic inner core of the micelles formed by poly(γbenzyl L-glutamate)(PBLG) segments can act as an incorporation site for hydrophobic drugs.The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases.The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.
文摘目的 探讨聚乙二醇干扰素α-2a与替诺福韦酯对高病毒载量慢性乙肝初治患者血清单核因子(monokine induced by IFN-γ,Mig)、调节活化正常T细胞表达和分泌的趋化因子(egulated upon activation normal T cell expressed and secreted,RANTES)以及肝纤维化指标表达的影响。方法 对赣州市人民医院2020年5月—2021年5月收治的129例慢性乙肝患者展开回顾性分析,按照治疗方案分组,将使用替诺福韦酯治疗的64例患者归为常规组,将使用聚乙二醇干扰素α-2a与替诺福韦酯联合治疗的65例患者纳入联合组。2组治疗时间均为6个月,治疗后比较2组肝功能指标[总胆红素(total bilirubin,TBIL)、谷丙转氨酶(alanine aminotransferase,ALT)以及谷草转氨酶(aspartate aminotransferase,AST)],对比2组血清Mig、RANTES水平,记录2组肝纤维化指标[层连黏蛋白(laminin,LN)、Ⅲ型前胶原蛋白(procollagen typeⅢ,PCⅢ)、Ⅳ型肽原(CollagenⅣ,Ⅳ-C)、透明质酸酶(hyaluronidase,HA)],观察2组乙肝病毒脱氧核糖核酸(hepatitis B virus deoxyribonucleic acid,HBV-DNA)转阴率与乙型肝炎病毒e抗原(hepatitis B e antigen,HBeAg)转阴率。结果 治疗后,联合组TBIL、ALT以及AST均比常规组低(P<0.05)。治疗后,联合组血清Mig、RANTES水平低于常规组(P<0.05)。治疗后,联合组LN、PCⅢ、Ⅳ-C和HA水平均比常规组低(P<0.05)。联合组HBV-DNA、HBeAg转阴率为分别86.15%、75.38%,高于常规组的65.63%、54.69%(P<0.05)。结论 对高病毒载量慢性乙肝初治患者采用聚乙二醇干扰素α-2a与替诺福韦酯联合治疗,可改善患者肝功能与肝纤维化指标,降低血清Mig、RANTES水平,有效促进HBV-DNA、HBeAg转阴。该方法可作为治疗慢性乙肝的优选方案。
