聚乙交酯丙交酯类共聚物(PGLA)聚合工艺中,催化剂多采用锡基催化剂,过量的残留锡(Sn)会对人体造成生物毒害。因此,为有效监控聚合工艺中生产物料的Sn含量,需要建立一套准确并快速的检测方法。通过优化微波消解条件和配方,并配合电感耦...聚乙交酯丙交酯类共聚物(PGLA)聚合工艺中,催化剂多采用锡基催化剂,过量的残留锡(Sn)会对人体造成生物毒害。因此,为有效监控聚合工艺中生产物料的Sn含量,需要建立一套准确并快速的检测方法。通过优化微波消解条件和配方,并配合电感耦合等离子体发射光谱(ICP-OES)法,建立了可用于测定PGLA产品中Sn含量的分析方法。称取0.10 g PGLA试样,以7 mL 65%~68%硝酸(HNO3)为消解液,消解温度最高为220℃。采用内标法进行定性定量分析,样品重复度好,RSD为3.65%。加标回收率在112%~115%,满足PGLA试样中的Sn含量分析需求,为工艺优化和产品质量控制提供了一种简单、实用的分析方法。展开更多
A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 a...A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.展开更多
文摘聚乙交酯丙交酯类共聚物(PGLA)聚合工艺中,催化剂多采用锡基催化剂,过量的残留锡(Sn)会对人体造成生物毒害。因此,为有效监控聚合工艺中生产物料的Sn含量,需要建立一套准确并快速的检测方法。通过优化微波消解条件和配方,并配合电感耦合等离子体发射光谱(ICP-OES)法,建立了可用于测定PGLA产品中Sn含量的分析方法。称取0.10 g PGLA试样,以7 mL 65%~68%硝酸(HNO3)为消解液,消解温度最高为220℃。采用内标法进行定性定量分析,样品重复度好,RSD为3.65%。加标回收率在112%~115%,满足PGLA试样中的Sn含量分析需求,为工艺优化和产品质量控制提供了一种简单、实用的分析方法。
文摘A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.
