Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the ex...Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.展开更多
Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectro...Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy,transmission electron microscopy and UV spectroscopy.It was found that the hydrophobic inner core of the micelles formed by poly(γbenzyl L-glutamate)(PBLG) segments can act as an incorporation site for hydrophobic drugs.The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases.The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.展开更多
文摘Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.
文摘Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy,transmission electron microscopy and UV spectroscopy.It was found that the hydrophobic inner core of the micelles formed by poly(γbenzyl L-glutamate)(PBLG) segments can act as an incorporation site for hydrophobic drugs.The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases.The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.
