AIM： To investigate the role of vascular endothelial growth factor （VEGF/and its receptors VEGFR-1 and 2 in the growth and differentiation of gastrointestinal strornal tumors （GISTs）. METHODS： Thirty-three GISTs,...AIM： To investigate the role of vascular endothelial growth factor （VEGF/and its receptors VEGFR-1 and 2 in the growth and differentiation of gastrointestinal strornal tumors （GISTs）. METHODS： Thirty-three GISTs, 15 leiomyomas and 6 schwannomas were examined by immunohistochemistry in this study. RESULTS： VEGF protein was expressed in the cytoplasm of tumor cells, and VEGFRol and 2 were expressed both in the cytoplasm and on the membrane of all tumors. Irnrnunohistochernical staining revealed that 26 GISTs （78.8%）, 9 leiornyornas （60.0%） and 3 schwannornas （50.0%/were positive for VEGF; 24 GISTs （72.7%/, 12 leiornyornas （80.0%） and 4 schwannornas （66.7%） were positive for VEGFR-1; 30 GISTs （90.9%/, 5 leiornyornas （33.3%/and 4 schwannornas （66.7%） were positive for VEGFR-2. VEGFR-2 expression was statistically different between GISTs and leiomyomas （P 〈 0.0001）. However, there was no correlation between the expression of VEGF pathway componenets and the clinical risk categories. CONCLUSION： Our results suggest that the VEGF pathway may play an important role in the differentiation of GISTs, leiomyomas and schwannomas.展开更多
Gastrointestinal stromal tumor(GIST)is a non-epithelial neoplasm arising from the wall of the gastrointestinal(GI)tract.It is most frequently found in the stomach(60%-70%),followed by the small intestine(20%-30%),the ...Gastrointestinal stromal tumor(GIST)is a non-epithelial neoplasm arising from the wall of the gastrointestinal(GI)tract.It is most frequently found in the stomach(60%-70%),followed by the small intestine(20%-30%),the colorectum(10%),and the esophagus(<5%).Some GISTs occur in the omentum,mesentery and retroperitoneum.GIST arising in the retroperitoneum is extremely rare,and its radiological findings have not been well described.However GISTs account for 2%-3% of all gastric tumors.GISTs are one of the most common mesenchymal tumors of the gastrointestinal tract.GIST referred to in the older medical literature as leiomyomas,leiomyoblastomas,and leiomyosarcomas because they were believed to originate from the smooth muscle layers of the wall of the gastrointestinal tract.Recently,however,immunoreactivity for KIT(CD117,a tyrosine kinase growth factor receptor)has differentiated gastrointestinal stromal tumors from true leiomyomas,leiomyosarcomas,neurofibromas,and schwannomas.In this review,we summarize the imaging findings of gastrointestinal stromal tumors and to determine whether some imaging features are useful for predicting malignancy in these tumors.展开更多
文摘AIM： To investigate the role of vascular endothelial growth factor （VEGF/and its receptors VEGFR-1 and 2 in the growth and differentiation of gastrointestinal strornal tumors （GISTs）. METHODS： Thirty-three GISTs, 15 leiomyomas and 6 schwannomas were examined by immunohistochemistry in this study. RESULTS： VEGF protein was expressed in the cytoplasm of tumor cells, and VEGFRol and 2 were expressed both in the cytoplasm and on the membrane of all tumors. Irnrnunohistochernical staining revealed that 26 GISTs （78.8%）, 9 leiornyornas （60.0%） and 3 schwannornas （50.0%/were positive for VEGF; 24 GISTs （72.7%/, 12 leiornyornas （80.0%） and 4 schwannornas （66.7%） were positive for VEGFR-1; 30 GISTs （90.9%/, 5 leiornyornas （33.3%/and 4 schwannornas （66.7%） were positive for VEGFR-2. VEGFR-2 expression was statistically different between GISTs and leiomyomas （P 〈 0.0001）. However, there was no correlation between the expression of VEGF pathway componenets and the clinical risk categories. CONCLUSION： Our results suggest that the VEGF pathway may play an important role in the differentiation of GISTs, leiomyomas and schwannomas.
文摘Gastrointestinal stromal tumor(GIST)is a non-epithelial neoplasm arising from the wall of the gastrointestinal(GI)tract.It is most frequently found in the stomach(60%-70%),followed by the small intestine(20%-30%),the colorectum(10%),and the esophagus(<5%).Some GISTs occur in the omentum,mesentery and retroperitoneum.GIST arising in the retroperitoneum is extremely rare,and its radiological findings have not been well described.However GISTs account for 2%-3% of all gastric tumors.GISTs are one of the most common mesenchymal tumors of the gastrointestinal tract.GIST referred to in the older medical literature as leiomyomas,leiomyoblastomas,and leiomyosarcomas because they were believed to originate from the smooth muscle layers of the wall of the gastrointestinal tract.Recently,however,immunoreactivity for KIT(CD117,a tyrosine kinase growth factor receptor)has differentiated gastrointestinal stromal tumors from true leiomyomas,leiomyosarcomas,neurofibromas,and schwannomas.In this review,we summarize the imaging findings of gastrointestinal stromal tumors and to determine whether some imaging features are useful for predicting malignancy in these tumors.
