为研究京大戟醋制前后不同极性部位对斑马鱼胚胎肝、胃肠毒性的影响,实验以95%乙醇提取生、醋京大戟,经石油醚、二氯甲烷、乙酸乙酯依次萃取得不同极性部位。将受精后12 h (12 hpf)的斑马鱼胚胎暴露于不同浓度的溶液中持续至受精96 h (9...为研究京大戟醋制前后不同极性部位对斑马鱼胚胎肝、胃肠毒性的影响,实验以95%乙醇提取生、醋京大戟,经石油醚、二氯甲烷、乙酸乙酯依次萃取得不同极性部位。将受精后12 h (12 hpf)的斑马鱼胚胎暴露于不同浓度的溶液中持续至受精96 h (96 hpf),对斑马鱼胚胎的肝、胃肠进行毒性观察。结果显示,毒性随着样品浓度的增加而增强。京大戟醋制前后各极性部位对斑马鱼胚胎的肝、胃肠毒性主要表现为肝脏发育缓慢、肝面积变小、肝脏变性发黑、卵黄囊水肿、吸收延迟、出血、胃肠道蠕动减缓、胃肠道杯状细胞分泌功能异常等,醋制后毒性反应降低。其中石油醚和二氯甲烷部位肝、胃肠毒性作用较为明显,乙酸乙酯部位毒性较弱。以上结果说明,京大戟醋制后毒性降低,且石油醚、二氯甲烷部位是其产生肝、胃肠毒性的主要部位。展开更多
We report a case of primary gastrointestinal stromal tumor （GIST） of the liver. A 17-year-old man with a solid mass in the anterior segment of the right liver was asymptomatic with negative laboratory examinations w...We report a case of primary gastrointestinal stromal tumor （GIST） of the liver. A 17-year-old man with a solid mass in the anterior segment of the right liver was asymptomatic with negative laboratory examinations with the exception of positive HBV. Contrast-enhanced ultrasound （CEUS） revealed a hypervascular lesion in the arterial phase and hypoechoic features during the portal and late phases. However, enhanced spiral computed tomography （CT） showed hypoattenuation in all three phases. Following biopsy, immunohistochemical evaluation demonstrated positive CDl17. Different imaging features of primary GISTs of the liver are due to pathological properties and different working systems between CEUS and enhanced spiral CT.展开更多
文摘为研究京大戟醋制前后不同极性部位对斑马鱼胚胎肝、胃肠毒性的影响,实验以95%乙醇提取生、醋京大戟,经石油醚、二氯甲烷、乙酸乙酯依次萃取得不同极性部位。将受精后12 h (12 hpf)的斑马鱼胚胎暴露于不同浓度的溶液中持续至受精96 h (96 hpf),对斑马鱼胚胎的肝、胃肠进行毒性观察。结果显示,毒性随着样品浓度的增加而增强。京大戟醋制前后各极性部位对斑马鱼胚胎的肝、胃肠毒性主要表现为肝脏发育缓慢、肝面积变小、肝脏变性发黑、卵黄囊水肿、吸收延迟、出血、胃肠道蠕动减缓、胃肠道杯状细胞分泌功能异常等,醋制后毒性反应降低。其中石油醚和二氯甲烷部位肝、胃肠毒性作用较为明显,乙酸乙酯部位毒性较弱。以上结果说明,京大戟醋制后毒性降低,且石油醚、二氯甲烷部位是其产生肝、胃肠毒性的主要部位。
文摘We report a case of primary gastrointestinal stromal tumor （GIST） of the liver. A 17-year-old man with a solid mass in the anterior segment of the right liver was asymptomatic with negative laboratory examinations with the exception of positive HBV. Contrast-enhanced ultrasound （CEUS） revealed a hypervascular lesion in the arterial phase and hypoechoic features during the portal and late phases. However, enhanced spiral computed tomography （CT） showed hypoattenuation in all three phases. Following biopsy, immunohistochemical evaluation demonstrated positive CDl17. Different imaging features of primary GISTs of the liver are due to pathological properties and different working systems between CEUS and enhanced spiral CT.
