随着外科技术的发展,肝移植手术的适应证向病情复杂、严重的病人扩展,这些病人除肝功能处于终末期外,通常还合并其他重要肝外器官的功能损伤。肝移植术后早期肝外脏器功能管理策略有助于肝移植病人早期快速康复。本文就心、肺、肾、脑...随着外科技术的发展,肝移植手术的适应证向病情复杂、严重的病人扩展,这些病人除肝功能处于终末期外,通常还合并其他重要肝外器官的功能损伤。肝移植术后早期肝外脏器功能管理策略有助于肝移植病人早期快速康复。本文就心、肺、肾、脑等重要肝外脏器在成人肝移植术后早期的管理策略作详细论述。术后继续进行血流动力学监测有助于维持供肝灌注,对前负荷、心肌收缩力及后负荷三个方面的评估管理非常重要。目前指南明确推荐术后早期拔管,对于术后肺部并发症的常规筛查有助于脱机。术后急性肾损伤的诊断遵循改善全球肾脏病预后组织(Kidney Disease:Improving Global Outcomes,KDIGO)的定义,肝移植术后早期延迟使用钙调磷酸酶抑制剂方案有利于肾功能保护。启动肾脏替代治疗的时机目前没有统一意见。肝硬化和肝性脑病病史会引起神经系统恢复受损,对肝性脑病正确诊断非常重要但很困难。展开更多
Living donor liver transplantation (LDLT) has gone through its formative years and established as a legitimate treatment when a deceased donor liver graft is not timely or simply not available at all. Nevertheless, LD...Living donor liver transplantation (LDLT) has gone through its formative years and established as a legitimate treatment when a deceased donor liver graft is not timely or simply not available at all. Nevertheless, LDLT is characterized by its technical complexity and ethical controversy. These are the consequences of a single organ having to serve two subjects, the donor and the recipient, instantaneously. The transplant community has a common ground on assuring donor safety while achieving predictable recipient success. With this background, a reflection of the development of LDLT may be appropriate to direct future research and patient-care efforts on this life-saving treatment alternative.展开更多
文摘随着外科技术的发展,肝移植手术的适应证向病情复杂、严重的病人扩展,这些病人除肝功能处于终末期外,通常还合并其他重要肝外器官的功能损伤。肝移植术后早期肝外脏器功能管理策略有助于肝移植病人早期快速康复。本文就心、肺、肾、脑等重要肝外脏器在成人肝移植术后早期的管理策略作详细论述。术后继续进行血流动力学监测有助于维持供肝灌注,对前负荷、心肌收缩力及后负荷三个方面的评估管理非常重要。目前指南明确推荐术后早期拔管,对于术后肺部并发症的常规筛查有助于脱机。术后急性肾损伤的诊断遵循改善全球肾脏病预后组织(Kidney Disease:Improving Global Outcomes,KDIGO)的定义,肝移植术后早期延迟使用钙调磷酸酶抑制剂方案有利于肾功能保护。启动肾脏替代治疗的时机目前没有统一意见。肝硬化和肝性脑病病史会引起神经系统恢复受损,对肝性脑病正确诊断非常重要但很困难。
文摘Living donor liver transplantation (LDLT) has gone through its formative years and established as a legitimate treatment when a deceased donor liver graft is not timely or simply not available at all. Nevertheless, LDLT is characterized by its technical complexity and ethical controversy. These are the consequences of a single organ having to serve two subjects, the donor and the recipient, instantaneously. The transplant community has a common ground on assuring donor safety while achieving predictable recipient success. With this background, a reflection of the development of LDLT may be appropriate to direct future research and patient-care efforts on this life-saving treatment alternative.