期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
130例慢性系统疾病性贫血患者的红细胞分布宽度分析 被引量:2
1
作者 吕霞飞 吴茅 《浙江临床医学》 2004年第9期760-761,共2页
目的 了解慢性系统疾病性贫血中肝性贫血、肾性贫血、糖尿病性贫血患者的红细胞分布宽度 (RDW)的差异 ,探讨RDW的临床实验室辅助诊断价值。方法 用CoulterSTKS血细胞分析仪测定40例肝性贫血、40例肾性贫血和50例糖尿病性贫血患者的RDW... 目的 了解慢性系统疾病性贫血中肝性贫血、肾性贫血、糖尿病性贫血患者的红细胞分布宽度 (RDW)的差异 ,探讨RDW的临床实验室辅助诊断价值。方法 用CoulterSTKS血细胞分析仪测定40例肝性贫血、40例肾性贫血和50例糖尿病性贫血患者的RDW值 ,比较三者RDW值的差异。同时设置40例门诊体检健康者作为正常对照。结果 肝性贫血患者的RDW值较正常对照组明显升高 ( p<0.01) ,肾性贫血患者的RDW值也较正常对照组为高 ( p<0.05) ,糖尿病性贫血患者的RDW值与正常对照组无显著差异 ( p>0.05)。不同慢性系统疾病性贫血男、女患者之间RDW值均无显著差异 (p>0.05)。中重度肝性贫血和糖尿病贫血患者RDW值高于轻度患者 (p<0.01,p<0.05)。结论 RDW值的测定对临床鉴别不同慢性系统疾病性贫血有一定的参考价值 ,对中度以上糖尿病患者测定RDW值有临床意义。 展开更多
关键词 慢性系统疾病性贫血 红细胞分布宽度 实验室诊断 肝性贫血 性贫血 糖尿病贫血
下载PDF
慢性系统疾病性贫血红细胞分布宽度分析 被引量:1
2
作者 马永能 张素芬 +4 位作者 张鹏 潘淑 方华 董波 谢正国 《实用医技杂志》 2006年第11期1821-1823,共3页
目的:了解慢性系统疾病性贫血中肝性贫血、肾性贫血、糖尿病性贫血患者的红细胞分布宽度(RDW)的差异,探讨RDW的临床实验室辅助鉴别诊断价值。方法:用SysmexSF-3000全自动血细胞分析仪测定45例肝性贫血、45例肾性贫血和55例糖尿病性贫血... 目的:了解慢性系统疾病性贫血中肝性贫血、肾性贫血、糖尿病性贫血患者的红细胞分布宽度(RDW)的差异,探讨RDW的临床实验室辅助鉴别诊断价值。方法:用SysmexSF-3000全自动血细胞分析仪测定45例肝性贫血、45例肾性贫血和55例糖尿病性贫血患者的RDW值,比较三者RDW值的差异。同时设置45例门诊体检健康者作为正常对照。结果:肝性贫血患者的RDW值较正常对照组明显升高(P<0.01),肾性贫血患者的RDW值也较正常对照组高(P<0.05),糖尿病性贫血患者的RDW值与正常对照组差异无显著性(P>0.05)。不同慢性系统疾病性贫血男、女患者之间RDW值差异均无显著性(P>0.05)。中重度肝性贫血和糖尿病贫血患者RDW值高于轻度患者(P<0.01,P<0.05)。结论:RDW值的测定对临床鉴别此三种不同类别慢性系统疾病性贫血有一定的参考价值,对中度贫血以上糖尿病患者测定RDW值有临床意义。 展开更多
关键词 慢性系统疾病性贫血 肝性贫血 性贫血 糖尿病性贫血 红细胞分布宽度
下载PDF
Spectrum of anemia associated with chronic liver disease 被引量:15
3
作者 Rosario Gonzalez-Casas E Anthony Jones Ricardo Moreno-Otero 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第37期4653-4658,共6页
Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepa... Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically signif icant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirininduced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by defi ciency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption. 展开更多
关键词 ANEMIA Liver disease Liver failure Aplastic anemia Pegylated interferon RIBAVIRIN ALCOHOL
下载PDF
Plasma erythropoietin levels in anaemic and non-anaemic patients with chronic liver diseases 被引量:5
4
作者 Cosimo MarcelloBruno Sergio Neri +6 位作者 ClaudioSciacca Gaetano Bertino Pietro DiPrima Danila Cilio Luciano Caruso Raffaello Cristaldi Rinaldo Pellicano 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第9期1353-1356,共4页
AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls.METHODS: We examined 31 anaemic (ALC) and ... AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls.METHODS: We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients, 21 non-anaemic subjects with chronic active hepatitis (CAH), 24 patients with iron-deficiency anaemia (ID) and 15 healthy controls. Circulating Epo levels (ELISA; R&D Systems, Europe Ltd, Abingdon,UK) and haemoglobin (Hb) concentration were determined in all subjects.RESULTS: Mean±SD of Epo values was 26.9±10.8 mU/mL in ALC patients, 12.5±8.0 mU/mL in NALC subjects,11.6±6.3 mU/mL in CAH patients, 56.4±12.7 mU/mL in the cases of ID and 9.3±2.6 mU/mL in controls. No significant difference (P>0.05) was found in Epo levels between controls, CAH and NALC patients. ALC individuals had higher Epo levels (P<0.01) than these groups whereas ID subjects had even higher levels (P<0.001) than patients suffering from ALC.CONCLUSION: Increased Epo values in cirrhotics, are only detectable when haemoglobin was lesser than 12 g/dL.Nevertheless, this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears blunted and inadequate in comparison to the degree of anaemia. 展开更多
关键词 Aged Anemia Iron-Deficiency ERYTHROPOIETIN Female HEMOGLOBINS Hepatitis Chronic Humans Liver Cirrhosis Male Middle Aged Regression Analysis
下载PDF
Hepatocellular carcinoma with chronic B-type hepatitis complicated by autoimmune hemolytic anemia:A case report 被引量:2
5
作者 Toshie Okada Keiichi Kubota +2 位作者 Junji Kita Masato Kato Tokihiko Sawada 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第32期4401-4404,共4页
A 57-year-old man consulted a local hospital because of a persistent slight fever. At the age of 37 years he was diagnosed having B-type hepatitis, but left the liver dysfunction untreated. Twenty years later, he was ... A 57-year-old man consulted a local hospital because of a persistent slight fever. At the age of 37 years he was diagnosed having B-type hepatitis, but left the liver dysfunction untreated. Twenty years later, he was diagnosed having chronic hepatitis B, hepatocellular carcinoma (HCC) and macrocytic anemia, and referred to our hospital for further investigation. A HCC with a maximum diameter of 5.2 cm was detected in segment 8. Results of blood tests included 1.8 mg/dL serum total bilirubin, 0.9 mg/dL bilirubin, less than 10 mg/dL haptoglobin, 7.9 g/dL hemoglobin, 130 fL MCV, and 14.5% reticuloo/tes. A bone marrow sample showed erythroid hyperplasia. The direct Coombs test gave a positive result. We diagnosed the anemia as autoimmmune hemolytic anemia (AIHA), for which prednisolone could not be administered due to positivity for HBsAg and HBeAg. After preparation of washed blood cells for later transfusion, the patient underwent systematic resection of segment 8. The cut surface of the resected specimen demonstrated an encapsulated yellow-brownish tumor measuring 52 mmx 40 mm which was diagnosed pathologicaly as moderately differentiated HCC. On the 9th postoperative day, the patient's temperature rose to 38℃, and exacerbated hemolysis was observed. The maximum total bilirubin value was 5.8 mg/dL and minimum hemoglobin level was 4.6 g/dL. He tolerated this period without blood transfusion. Currently he is being followed up as an outpatient, and shows no signs of HCC recurrence or symptoms of anemia. AIHA associated with HBV infection has been described in only three previous cases, and the present case is the first in which surgery was performed for accompanying HCC. 展开更多
关键词 Hepatocellular carcinoma B-type hepatitis Auto-immune hemolytic anemia
下载PDF
Herbal medicine Ninjinyoeito ameliorates ribavirin-induced anemia in chronic hepatitis C: A randomized controlled trial 被引量:1
6
作者 Yoshiharu Motoo Hisatsugu Mouri +3 位作者 Koushiro Ohtsubo Yasushi Yamaguchi Hiroyuki Watanabe Norio Sawabu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第26期4013-4017,共5页
AIM:Ribavirin (RBV) shows a strong antiviral effect on hepatitis C virus when used in combination with interferon. However, RBV-induced anemia is a major problem in this therapy. It would be of great clinical importan... AIM:Ribavirin (RBV) shows a strong antiviral effect on hepatitis C virus when used in combination with interferon. However, RBV-induced anemia is a major problem in this therapy. It would be of great clinical importance to ameliorate the anemia without reducing the RBV dose. We report here that, Ninjinyoeito (NYT), a herbal medicine can reduce the RBV-induced anemia. METHODS: Twenty-three patients with chronic hepatitis C were treated with interferon alpha 2b plus RBV with (NYT group) or without (control group) NYT by a randomized selection. Eighteen patients completed the treatment schedule, and hemato-biochemical and virological effects were evaluated. RESULTS: There was no significant difference in biochemical and virological responses between the two groups. However, anemia was significantly reduced in the NYT group compared with the control group. The maximal decrease of Hb in the NYT group (2.59±1.10 g/dL) was significantly (P= 0.026) smaller than that in the control group (3.71±0.97 g/dL). There was no significant difference in serum glutathione peroxidase activity, serum RBV concentration, and Thl/Th2 balance between the two groups. There was no specific adverse effect in NYT administration. CONCLUSION: These results suggest that NYT could be used as a supportive remedy to reduce the RBV-induced anemia in the treatment of chronic hepatitis C. 展开更多
关键词 Chronic hepatitis C RIBAVIRIN INTERFERON Herbal medicine ANEMIA
下载PDF
Pure red cell aplasia caused by pegylated interferon-α-2a plus ribavirin in the treatment of chronic hepatitis C 被引量:1
7
作者 Cheng-Shyong Chang Hsuan-Yu Lin +2 位作者 Fu-Lien Yu Chien-Yu Tsai Sheng-Lei Yan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第16期2155-2158,共4页
Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia,reticulocytopenia and almost complete absence of erythroid precursors in bone marrow.The pathophysiology of PRCA ma... Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia,reticulocytopenia and almost complete absence of erythroid precursors in bone marrow.The pathophysiology of PRCA may be congenital or acquired.To our knowledge,there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis C.We report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis C.The diagnosis of PRCA was confirmed by the typical findings of bone marrow biopsy.The possible etiologies of our case are also discussed in this paper. 展开更多
关键词 Chronic hepatitis C Pegylated interferon-α2a Pure red cell aplasia RIBAVIRIN
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部