AIM： TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus （HCV） infection.METHODS： One hundred chronic HCV infection patients failed in interferon treatment were enr...AIM： TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus （HCV） infection.METHODS： One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo, or oral treatment alone, Primary end points were liver enzymes, HCV-RNA levels and histology.RESULTS： Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo （P = 0.05）. Histology activity index （HAI） score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo （P = 0.21）. HCV-RNA levels decreased by l-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo （P = NS）. In part 11 of the trial, oral administration of antioxidants was not associated with significant alterations in any of the end points.CONCLUSION： Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients.展开更多
The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver an...The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver antioxidant activity. Samples were analyzed by FRAP （ferric-reducing antioxidant power）, FRK （free radicals） and DPPH （2,2-diphenyl-l-picrylhydrazyl） methods. Oxidative stress values （metallo thionein, reduced glutathione, oxidized glutathione and reduced/oxidized glutation ration） were measured in the blood and liver. Biochemical parameters （serum albumin, uric acid and bilirubin） were monitored in the blood. The antioxidant activity measured by the FRK method was higher in the oregano supplement （P 〈 0.05） than in plantain and rosemary supplements.展开更多
The globe artichoke has become important as a medicinal herb in recent years following the discovery of cynarin. This bitter-tasting compound, which is found in the leaves, improves liver and gall bladder function, st...The globe artichoke has become important as a medicinal herb in recent years following the discovery of cynarin. This bitter-tasting compound, which is found in the leaves, improves liver and gall bladder function, stimulates the secretion of digestive juices, especially bile, and lowers blood cholesterol levels. The leaves are anticholesterolemic, antirheumatic, cholagogue, digestive, diuretic, hypoglycaemic and lithontripic. BEDGEN 40 , a compound made with Cynara scolymus L. （artichoke） extract and choline chloride was evaluated for growth performance and anti-oxidant activity in tilapia. There were four treatment groups; group 1 was fed only with a basal diet and served as the control, group 2 - 4 were experimental groups that received 150, 300, or 600 mg/kg BEDGEN 40 , respectively, added to the basal diet and fed for 8 weeks. The results showed signifi- cant differences for weight gain, feed conversion, and protein efficiency in fish diets containing 150, 300, or 600 mg/kg BEDGEN 40 compared to the control. Generally, BEDGEN 40 improved the body condition factor and hepatosomatic index of tilapia, and reduced liver fat content. Fish consum- ing BEDGEN 40 also exhibited improved liver antioxidant status. BEDGEN 40 （300, or 600 mg/kg） was also found to significantly reduce the mortality of tilapia subsequently challenged with Aeromonas hydrophila.展开更多
文摘AIM： TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus （HCV） infection.METHODS： One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo, or oral treatment alone, Primary end points were liver enzymes, HCV-RNA levels and histology.RESULTS： Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo （P = 0.05）. Histology activity index （HAI） score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo （P = 0.21）. HCV-RNA levels decreased by l-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo （P = NS）. In part 11 of the trial, oral administration of antioxidants was not associated with significant alterations in any of the end points.CONCLUSION： Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients.
文摘The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver antioxidant activity. Samples were analyzed by FRAP （ferric-reducing antioxidant power）, FRK （free radicals） and DPPH （2,2-diphenyl-l-picrylhydrazyl） methods. Oxidative stress values （metallo thionein, reduced glutathione, oxidized glutathione and reduced/oxidized glutation ration） were measured in the blood and liver. Biochemical parameters （serum albumin, uric acid and bilirubin） were monitored in the blood. The antioxidant activity measured by the FRK method was higher in the oregano supplement （P 〈 0.05） than in plantain and rosemary supplements.
文摘The globe artichoke has become important as a medicinal herb in recent years following the discovery of cynarin. This bitter-tasting compound, which is found in the leaves, improves liver and gall bladder function, stimulates the secretion of digestive juices, especially bile, and lowers blood cholesterol levels. The leaves are anticholesterolemic, antirheumatic, cholagogue, digestive, diuretic, hypoglycaemic and lithontripic. BEDGEN 40 , a compound made with Cynara scolymus L. （artichoke） extract and choline chloride was evaluated for growth performance and anti-oxidant activity in tilapia. There were four treatment groups; group 1 was fed only with a basal diet and served as the control, group 2 - 4 were experimental groups that received 150, 300, or 600 mg/kg BEDGEN 40 , respectively, added to the basal diet and fed for 8 weeks. The results showed signifi- cant differences for weight gain, feed conversion, and protein efficiency in fish diets containing 150, 300, or 600 mg/kg BEDGEN 40 compared to the control. Generally, BEDGEN 40 improved the body condition factor and hepatosomatic index of tilapia, and reduced liver fat content. Fish consum- ing BEDGEN 40 also exhibited improved liver antioxidant status. BEDGEN 40 （300, or 600 mg/kg） was also found to significantly reduce the mortality of tilapia subsequently challenged with Aeromonas hydrophila.
