It thas been reported that the various experimental liver injuries and patients with liver diseases are accompanied by intestinal endotoxemia (IETM). Up to now, the effect of IETM on the chronicity of hepatitis, its p...It thas been reported that the various experimental liver injuries and patients with liver diseases are accompanied by intestinal endotoxemia (IETM). Up to now, the effect of IETM on the chronicity of hepatitis, its pervention and treatment have received little attention.According to the study of a large number of animal experiments and clinics, we raise a new conception of the pathogenesis of hepatic injury in hepatitis:The various factors induce liver injury(for example,hepatic virus, alcohol, medicines and hepatotoxic agents and so on )by various specific mechanisms,which is called "The primary liver injury ". IETM is occurred in the deveopment of hepatitis. Endotoxin activated kupffer cells and produced a number of chemical mediators. The liver injury caused by mediators is called"The secondary liver injury". This "The secondary liver injury" depends on serious degree of IETM. The repeated and persistent hepatocellular necrosis in light IETM condition accompanying hepatocellular regeneration and inflammatory cells infiltration develop the chronic hepatitis and/or liver fibrosis, even cirrhosis and hepatocarcinoma. The severe IETM offen leads to overinflammation following serious hepatocellular necrosis, even grows up severe hepatitis, liver failure further is appeared.展开更多
文摘It thas been reported that the various experimental liver injuries and patients with liver diseases are accompanied by intestinal endotoxemia (IETM). Up to now, the effect of IETM on the chronicity of hepatitis, its pervention and treatment have received little attention.According to the study of a large number of animal experiments and clinics, we raise a new conception of the pathogenesis of hepatic injury in hepatitis:The various factors induce liver injury(for example,hepatic virus, alcohol, medicines and hepatotoxic agents and so on )by various specific mechanisms,which is called "The primary liver injury ". IETM is occurred in the deveopment of hepatitis. Endotoxin activated kupffer cells and produced a number of chemical mediators. The liver injury caused by mediators is called"The secondary liver injury". This "The secondary liver injury" depends on serious degree of IETM. The repeated and persistent hepatocellular necrosis in light IETM condition accompanying hepatocellular regeneration and inflammatory cells infiltration develop the chronic hepatitis and/or liver fibrosis, even cirrhosis and hepatocarcinoma. The severe IETM offen leads to overinflammation following serious hepatocellular necrosis, even grows up severe hepatitis, liver failure further is appeared.
