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白介素-37在慢性肝病病程中的作用进展
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作者 郭渔 魏黎 许烂漫 《现代实用医学》 2024年第4期550-552,F0003,共4页
慢性肝病是由多种病因(病毒、酒精、代谢异常、免疫及遗传代谢等)导致的肝细胞持续损伤和肝内慢性炎症及纤维化。一系列研究表明,各种细胞因子[如白介素-6(interleukin-6,IL-6)、IL-18及IL-22等]在慢性肝病的细胞炎症损伤及纤维化进程... 慢性肝病是由多种病因(病毒、酒精、代谢异常、免疫及遗传代谢等)导致的肝细胞持续损伤和肝内慢性炎症及纤维化。一系列研究表明,各种细胞因子[如白介素-6(interleukin-6,IL-6)、IL-18及IL-22等]在慢性肝病的细胞炎症损伤及纤维化进程中起着重要作用[1]。 展开更多
关键词 慢性肝病 炎症损伤 肝病病程 细胞因子 代谢异常 慢性炎症 肝细胞 遗传代谢
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慢性肝病患者的长寿经
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作者 韩绍安 《解放军健康》 1994年第4期30-30,共1页
慢性肝病患者的长寿经韩绍安慢性肝炎、肝硬化等慢性肝病病程绵长,病情又容易复发,其中一部分甚至预后不良,影响寿命。但是,实践证明,如能正确对待,认真做好自我保健,多数病人可以显著改善预后,其中一些人甚至可以享有高寿。总... 慢性肝病患者的长寿经韩绍安慢性肝炎、肝硬化等慢性肝病病程绵长,病情又容易复发,其中一部分甚至预后不良,影响寿命。但是,实践证明,如能正确对待,认真做好自我保健,多数病人可以显著改善预后,其中一些人甚至可以享有高寿。总结多数肝病寿星的经验,主要有以下几... 展开更多
关键词 慢性肝病患者 肝病病程 自我保健 慢性肝炎 高脂肪食品 绍安 实践证明 肠道细菌感染 肝细胞 代偿功能
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Factors associated with the overall survival of elderly patients with hepatocellular carcinoma 被引量:4
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作者 Hideki Fujii Yoshito Itoh +8 位作者 Naoki Ohnishi Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Kanji Yamaguchi Masahito Minami Takeshi Okanoue 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第16期1926-1932,共7页
AIM:To identify the factors associated with overall survival of elderly patients with hepatocellular carcinoma(HCC).METHODS:A total of 286 patients with HCC(male/female:178/108,age:46-100 years),who were diagnosed and... AIM:To identify the factors associated with overall survival of elderly patients with hepatocellular carcinoma(HCC).METHODS:A total of 286 patients with HCC(male/female:178/108,age:46-100 years),who were diagnosed and treated by appropriate therapeutic procedures between January 2000 and December 2010,were enrolled in this study.Patients were stratified into two groups on the basis of age:Elderly(≥ 75 years old) and non-elderly(< 75 years old).Baseline clinical characteristics as well as cumulative survival rates were then compared between the two groups.Univariate and multivariate analyses were used to identify the factors associated with prolonged overall survival of patients in each group.Cumulative survival rates in the two groups were calculated separately for each modified Japan Integrated Stage score(mJIS score) category by the Kaplan-Meier method.In addition,we compared the cumulative survival rates of elderly and non-elderly patients with good hepatic reserve capacity(≤ 2 points as per mJIS).RESULTS:In the elderly group,the proportion of female patients,patients with absence of hepatitis B or hepatitis C viral infection,and patients with coexisting extrahepatic comorbid illness was higher(56.8% vs 31.1%,P < 0.001;27.0% vs 16.0%,P = 0.038;33.8% vs 22.2%,P = 0.047;respectively) than that in the nonelderly group.In the non-elderly group,the proportion of hepatitis B virus(HBV)-infected patients was higher than that in the elderly group(9.4% vs 0%,P = 0.006).The cumulative survival rates in the elderly group were 53.7% at 3 years and 32.9% at 5 years,which were equivalent to those in the non-elderly group(55.9% and 39.4%,respectively),as shown by a log-rank test(P = 0.601).In multivariate analysis,prolonged survival was significantly associated with the extent of liver damage and stage(P < 0.001 and P < 0.001,respectively),but was not associated with patient age.However,on individual evaluation of factors in both groups,stage was significantly(P < 0.001) associated with prolonged survival.Regarding mJIS scores of ≤ 2,the rate of female patients with this score was higher in the elderly group when compared to that in the non-elderly group(P = 0.012) and patients ≥ 80 years of age tended to demonstrate shortened survival.CONCLUSION:Survival of elderly HCC patients was associated with liver damage and stage,but not age,except for patients ≥ 80 years with mJIS score ≤ 2. 展开更多
关键词 Age Hepatocellular carcinoma Liver damage STAGE SURVIVAL
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