Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC...Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC） and explore their clinical significance. Methods： The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical （IHC） staining and periodic acid-Schiff （PAS） reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results： PPARy was over-expressed （24/34） in HCC tissues, it was associated with tumor size （〉 5 cm, P = 0.027）, broken capsule （P = 0.014）, tendency to metastasis and recurrence （P = 0.001）. The MVD was higher （23/24） in HCC tissues than that in corresponding para-cancerous tissues （t = 18.925, P 〈 0.05）. There was a significant positive correlation between the over-expression of PPARy and high MVD （r = 0.519）. Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients （P = 0.013, 0.036 and 0.022, respectively; log-rank test）. Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC. Conclusion： The PPARy correlated with the development of microcirculatory in HCC. PPARy is a novel prognostic indicator for evaluating of HCC.展开更多
A case with an Alpha-fetoprotein-producing(AFP-producing) carcinoma originating from the rectum was described.A 41-year-old man,who underwent a palliative surgery for rectal carcinoma,was diagnosed with occupying live...A case with an Alpha-fetoprotein-producing(AFP-producing) carcinoma originating from the rectum was described.A 41-year-old man,who underwent a palliative surgery for rectal carcinoma,was diagnosed with occupying liver lesions and a remarkable AFP elevation(3484.61 ng/mL),and the AFP declined obviously 10 days after the palliative surgery.So we carried out a biopsy of the liver lesions.The histopathology was reported as low differentiation adenocarcinoma.The immunohistochemistry of the tumor cells via liver biopsy showed:Villin,CDX-2 was positive,Glypican-3 was partial positive,CK7,CK20,AFP,Hepatocyte were all negative.The initial histopathology was reported as an AFP-producing rectum adenocarcinoma with liver metastasis,which was a rare disease.So far,only 17 reports,none has been reported in China.Then,we summarize the characteristic of the disease:diagnosed with hepatic metastasis,raised serum AFP and a poor outcome,in addition to primary symptoms.This kind of disease is highly malignant.展开更多
文摘Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC） and explore their clinical significance. Methods： The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical （IHC） staining and periodic acid-Schiff （PAS） reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results： PPARy was over-expressed （24/34） in HCC tissues, it was associated with tumor size （〉 5 cm, P = 0.027）, broken capsule （P = 0.014）, tendency to metastasis and recurrence （P = 0.001）. The MVD was higher （23/24） in HCC tissues than that in corresponding para-cancerous tissues （t = 18.925, P 〈 0.05）. There was a significant positive correlation between the over-expression of PPARy and high MVD （r = 0.519）. Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients （P = 0.013, 0.036 and 0.022, respectively; log-rank test）. Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC. Conclusion： The PPARy correlated with the development of microcirculatory in HCC. PPARy is a novel prognostic indicator for evaluating of HCC.
文摘A case with an Alpha-fetoprotein-producing(AFP-producing) carcinoma originating from the rectum was described.A 41-year-old man,who underwent a palliative surgery for rectal carcinoma,was diagnosed with occupying liver lesions and a remarkable AFP elevation(3484.61 ng/mL),and the AFP declined obviously 10 days after the palliative surgery.So we carried out a biopsy of the liver lesions.The histopathology was reported as low differentiation adenocarcinoma.The immunohistochemistry of the tumor cells via liver biopsy showed:Villin,CDX-2 was positive,Glypican-3 was partial positive,CK7,CK20,AFP,Hepatocyte were all negative.The initial histopathology was reported as an AFP-producing rectum adenocarcinoma with liver metastasis,which was a rare disease.So far,only 17 reports,none has been reported in China.Then,we summarize the characteristic of the disease:diagnosed with hepatic metastasis,raised serum AFP and a poor outcome,in addition to primary symptoms.This kind of disease is highly malignant.
