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Gynura root induces hepatic veno-occlusive disease:A case report and review of the literature 被引量:27
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作者 Ning Dai Ying-Cong Yu +4 位作者 Tian-Hua Ren Jia-Guo Wu Yuan Jiang Lai-Gen Shen Jing Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第10期1628-1631,共4页
Gynura root has been used extensively in Chinese folk medicine and plays a role in promoting microcirculation and relieving pain.However,its hepatic toxicity should not be neglected.Recently,we admitted a 62-year old ... Gynura root has been used extensively in Chinese folk medicine and plays a role in promoting microcirculation and relieving pain.However,its hepatic toxicity should not be neglected.Recently,we admitted a 62-year old female who developed hepatic veno-occlusive disease(HVOD)after ingestion of Gynura root.Only a few articles on HVOD induced by Gynura root have been reported in the literature.It is suspected that pyrrolizidine alkaloids in Gynura root might be responsible for HVOD.In this paper,we report a case of HVOD and review the literature. 展开更多
关键词 Hepatic veno-occlusive disease Gynura root
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Budd-Chiari syndrome: A case with a combination of hepatic vein and superior vena cava occlusion 被引量:2
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作者 Yoshio Araki Chikara Sakaguchi +5 位作者 Izumi Ishizuka Masaya Sasaki Tomoyuki Tsujikawa Shigeki Koyama Akira Furukawa Yoshihide Fujiyama 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第24期3797-3799,共3页
We here report a recent, rare case of Budd-Chiari syndrome, associated with a combination of hepatic vein and superior vena cava occlusion. A young female, who had been ingood health, was admitted to our hospital beca... We here report a recent, rare case of Budd-Chiari syndrome, associated with a combination of hepatic vein and superior vena cava occlusion. A young female, who had been ingood health, was admitted to our hospital because of massive ascites. The patient had used no oral contraceptives. Tests for coagulation disorders, hematological disorders, and antiphospholipid syndrome were all negative. BuddChiari syndrome was diagnosed by radiographic examination. The patient was suffering from a combination of hepatic vein and superior vena cava occlusion. In particular, the venous flow returned from the liver mainly through a right accessory hepatic vein, and stenosis was recognized at the orifice of this collateral vein into the vena cava.Subsequently, the patient underwent percutaneous balloon dilatation therapy for this stenosis. After this treatment, the massive ascites was gradually reduced, and she was discharged from our hospital. It has now been one year since discharge, and the patient has been doing well. If deteriorating liver function or intractable ascites occur again, a liver transplantation may be anticipated. This is the first case report of Budd-Chiari syndrome associated with a superior vena cava occlusion. 展开更多
关键词 Budd-Chiari syndrome Hepatic vein occlusion Superior vena cava ocdusion Percutaneous balloon dilatation
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One patient of hepatic veno-occlusive disease with an increased cancer antigen-125 expression caused by misuse of Sedum aizoon
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作者 Siliang Wu 《TMR Clinical Research》 2018年第1期15-19,共5页
Nowadays hepatic veno-occlusive disease is mainly caused by Sedum aizoon in China,and its prognosis dependents on the dosage and courses of the Sedum aizoon treatment but lacks other objective indicators.There are a l... Nowadays hepatic veno-occlusive disease is mainly caused by Sedum aizoon in China,and its prognosis dependents on the dosage and courses of the Sedum aizoon treatment but lacks other objective indicators.There are a lot relationships between CA125 level and liver cirrhosis,this case had a obvious increased CA125 level in the serum,hydrothorax and ascites,following by the liver cirrhosis in a short time,and then died of upper gastrointestinal bleeding.By now we guess that CA125 level could forecast the liver cirrhosis following by hepatic veno-occlusive,which will become the prognosis of the hepatic veno-occlusive. 展开更多
关键词 Hepatic veno-occlusive disease Sedum aizoon Cancer antigen-125
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PAI-1在造血干细胞移植早期血栓病变中的临床意义 被引量:4
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作者 韩悦 卢晓旭 +6 位作者 吴德沛 孙爱宁 张威 胡晓慧 高海丽 王兆钺 阮长耿 《中华血液学杂志》 CAS CSCD 北大核心 2009年第11期731-734,共4页
目的观察造血干细胞移植早期患者纤溶酶原激活剂抑制物-1(PAI-1)指标的动态改变,探讨其在移植相关性血栓病变中的临床意义。方法采用ELISA法监测95例接受造血干细胞移植的患者在预处理过程中以及干细胞移植后4周内血浆中PAI-1等凝血... 目的观察造血干细胞移植早期患者纤溶酶原激活剂抑制物-1(PAI-1)指标的动态改变,探讨其在移植相关性血栓病变中的临床意义。方法采用ELISA法监测95例接受造血干细胞移植的患者在预处理过程中以及干细胞移植后4周内血浆中PAI-1等凝血指标的动态改变。根据移植后并发症的发生情况将患者分为平稳组、急性移植物抗宿主病(aGVHD)组、血栓组以及感染组进行统计学分析。结果造血干细胞移植过程中患者的各项凝血相关指标呈现动态改变。其中PAI-1水平在预处理后升高,移植当周下降,随后又逐步上升。根据移植后首先出现的并发症情况将患者分为四组:平稳组41例、aGVHD组29例、血栓组6例[肝静脉闭塞病(VOD)5例,血栓性微血管病(TMA)1例]和感染组19例。自体移植中发生血栓1例(3.3%),异基因移植组发生血栓5例(7.7%)。移植后发生血栓患者PAI-1水平较发生血栓者无增高,后者又高于自体移植无血栓患者。有并发症的移植患者PAI-1水平明显高于无并发症患者。出现血栓病变的6例患者PAI-1极度升高,为(62.8±7.5)μg/L,明显高于GVHD组[(45.1±9.1)μg/L]和感染组[(50.0±11.2)μg/L]患者的移植后平均水平。结论血浆PAI-1水平的增高可能是移植相关性血栓病变的特异性指标,提示VOD、TMA等血栓并发症的发生。PAI-1水平的明显升高有益于移植相关性血栓并发症的早期诊断。 展开更多
关键词 移植相关性血栓病变 纤溶酶原激活剂抑制物-1 造血干细胞移植 肝静脉闭 塞病
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