Gastrointestinal （GI） sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do sev...Gastrointestinal （GI） sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do severe and life-threatening problems occur. The pathogenesis of abnormal upper GI sensory-motor function in diabetes is incompletely understood and is most likely multi-factorial of origin. Diabetic autonomic neuropathy as well as acute suboptimal control of diabetes has been shown to impair GI motor and sensory function. Morphological and biomechanical remodeling of the GI wall develops during the duration of diabetes, and may contribute to motor and sensory dysfunction. In this review sensory and motility disorders of the upper GI tract in diabetes is discussed; and the morphological changes and biomechanical remodeling related to the sensory-motor dysfunction is also addressed.展开更多
AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidem...AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final visit.RESULTS: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk formulas.CONCLUSION: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice.展开更多
Objective:To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods:Observing group NDP/FT-207 regimen:given nedaplatin 80-100 mg/m2 on day 1 an...Objective:To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods:Observing group NDP/FT-207 regimen:given nedaplatin 80-100 mg/m2 on day 1 and futraful 500-600 mg/m2 on day 1 to 5;control group:DDP/5-Fu regimen received cisplatin 80-100 mg/m2 on day 1 and 5-Fluorouracil 500-750 mg/m2 on day 1 to 5.In both groups per 28 days was a cycle, 2-3 cycles were one course.Results:Response and toxicity could be assessed in all the 78 patients, 42 patients were in observing group, the other 36 patients were in control group.The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1%(24/42) and 50%(18/36) respectively.The two groups have no significant difference.The toxicities as gastrointestinal disorders and myelosuppression in observing group was lighter than those in control group.Conclusion:The combination of NDP and FT-207 is a safer and effective regimen.展开更多
基金Supported by the Danish Diabetes Association, the Research Council of North Jutland County, the Toyota Foundation and the SparNord Foundation
文摘Gastrointestinal （GI） sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do severe and life-threatening problems occur. The pathogenesis of abnormal upper GI sensory-motor function in diabetes is incompletely understood and is most likely multi-factorial of origin. Diabetic autonomic neuropathy as well as acute suboptimal control of diabetes has been shown to impair GI motor and sensory function. Morphological and biomechanical remodeling of the GI wall develops during the duration of diabetes, and may contribute to motor and sensory dysfunction. In this review sensory and motility disorders of the upper GI tract in diabetes is discussed; and the morphological changes and biomechanical remodeling related to the sensory-motor dysfunction is also addressed.
文摘AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final visit.RESULTS: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk formulas.CONCLUSION: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice.
文摘Objective:To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods:Observing group NDP/FT-207 regimen:given nedaplatin 80-100 mg/m2 on day 1 and futraful 500-600 mg/m2 on day 1 to 5;control group:DDP/5-Fu regimen received cisplatin 80-100 mg/m2 on day 1 and 5-Fluorouracil 500-750 mg/m2 on day 1 to 5.In both groups per 28 days was a cycle, 2-3 cycles were one course.Results:Response and toxicity could be assessed in all the 78 patients, 42 patients were in observing group, the other 36 patients were in control group.The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1%(24/42) and 50%(18/36) respectively.The two groups have no significant difference.The toxicities as gastrointestinal disorders and myelosuppression in observing group was lighter than those in control group.Conclusion:The combination of NDP and FT-207 is a safer and effective regimen.
