The human microbiota is an aggregate of microorganisms residing in the human body, mostly in the gastrointestinal tract （GIT）. Our gut microbiota evolves with us and plays a pivotal role in human health and disease....The human microbiota is an aggregate of microorganisms residing in the human body, mostly in the gastrointestinal tract （GIT）. Our gut microbiota evolves with us and plays a pivotal role in human health and disease. In recent years, the microbiota has gained increasing attention due to its impact on host metabolism, physiology, and immune system development, but also because the perturbation of the microbiota may result in a number of diseases. The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer. It may also be linked to disorders such as nonalcoholic fatty liver disease （NAFLD）; obesity and diabetes, which are characterized as ＂lifestyle diseases＂ of the industrial- ized world; coronary heart disease; and neurological disorders. Although the revolution in molecular technologies has provided us with the necessary tools to study the gut microbiota more accurately, we need to elucidate the relationships between the gut microbiota and several human pathologies more precisely, as understanding the impact that the microbiota plays in various diseases is fundamental for the development of novel therapeutic strategies. Therefore, the aim of this review is to provide the read- er with an updated overview of the importance of the gut microbiota for human health and the poten- tial to manipulate gut microbial composition for purposes such as the treatment of antibiotic-resistant Clostridium difficile （C difficile） infections. The concept of altering the gut community by microbial intervention in an effort to improve health is currently in its infancy. However, the therapeutic implications appear to be very great. Thus, the removal of harmful organisms and the enrichment of beneficial mi- crobes may protect our health, and such efforts will pave the way for the development of more rational treatment options in the future.展开更多
Water is a strategically limited natural resource, and currently Iraq is in the grip of an extended drought period. It is needed to look for alternative water sources and work towards achieving high level of sustainab...Water is a strategically limited natural resource, and currently Iraq is in the grip of an extended drought period. It is needed to look for alternative water sources and work towards achieving high level of sustainability. Measurements for gray water samples were carried out including pH, EC （electrical conductivity）, TDS （total dissolved solids）, TS （total solids）, TSS （total suspended solids）, DO （dissolved oxygen）, BOD5 （biochemical oxygen demand）, COD （chemical oxygen demand）, alkalinity, chlorides （Cl）, calcium （Ca）, sodium （Na）, magnesium （Mg）, potassium （K）, lead （Pb）, TC （total coliforms）, TF （total fecal coliforms）, and nitrate （NO3）. The goals of this study are to estimate quantities of fresh water consumption and gray water generated in typical Baghdadian households, and to investigate gray water quality （physical, chemical and biological）. The major results can be summarized as follows： （1） The daily water consumption in Baghdad ranged from 75 Lpcd to 176 Lpcd with an average of 116 Lpcd; （2） the maximum daily consumption in Baghdad ranged from 124 Lpcd to 327 Lpcd with an average of 186 Lpcd; （3） the maximum hourly consumption in Baghdad ranged from 154 Lpcd to 900 Lpcd with an average of 308 Lpcd; （4） gray water generation in Baghdad ranged from 34 Lpcd to 139 Lpcd with an average of 68 Lpcd, and that gray water generated constituted 58% to 72% of total consumption.展开更多
Gastrointestinal microbiome,containing at least 100 trillion bacteria,resides in the mucosal surface of human intestine.Recent studies show that perturbations in the microbiota may influence physiology and link to a n...Gastrointestinal microbiome,containing at least 100 trillion bacteria,resides in the mucosal surface of human intestine.Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases,including colon tumorigenesis.Colorectal cancer(CRC),the third most common cancer,is the disease resulting from multi-genes and multi-factors,but the mechanistic details between gut microenvironment and CRC remain poorly characterized.Thanks to new technologies such as metagenome sequencing,progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible,which has facilitated studies about microbiota composition,taxonomic alterations and host interactions.Different bacterial species and their metabolites play critical roles in the development of CRC.Also,microbiota is important in the inflammatory response and immune processes deregulation during the development and progression of CRC.This review summarizes current studies regarding the association between gastrointestinalmicrobiota and the development of CRC,which provides insights into the therapeutic strategy of CRC.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China （21375144 and 21105115） and the National Basic Research Program of China （2012CB934004）.
文摘The human microbiota is an aggregate of microorganisms residing in the human body, mostly in the gastrointestinal tract （GIT）. Our gut microbiota evolves with us and plays a pivotal role in human health and disease. In recent years, the microbiota has gained increasing attention due to its impact on host metabolism, physiology, and immune system development, but also because the perturbation of the microbiota may result in a number of diseases. The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer. It may also be linked to disorders such as nonalcoholic fatty liver disease （NAFLD）; obesity and diabetes, which are characterized as ＂lifestyle diseases＂ of the industrial- ized world; coronary heart disease; and neurological disorders. Although the revolution in molecular technologies has provided us with the necessary tools to study the gut microbiota more accurately, we need to elucidate the relationships between the gut microbiota and several human pathologies more precisely, as understanding the impact that the microbiota plays in various diseases is fundamental for the development of novel therapeutic strategies. Therefore, the aim of this review is to provide the read- er with an updated overview of the importance of the gut microbiota for human health and the poten- tial to manipulate gut microbial composition for purposes such as the treatment of antibiotic-resistant Clostridium difficile （C difficile） infections. The concept of altering the gut community by microbial intervention in an effort to improve health is currently in its infancy. However, the therapeutic implications appear to be very great. Thus, the removal of harmful organisms and the enrichment of beneficial mi- crobes may protect our health, and such efforts will pave the way for the development of more rational treatment options in the future.
文摘Water is a strategically limited natural resource, and currently Iraq is in the grip of an extended drought period. It is needed to look for alternative water sources and work towards achieving high level of sustainability. Measurements for gray water samples were carried out including pH, EC （electrical conductivity）, TDS （total dissolved solids）, TS （total solids）, TSS （total suspended solids）, DO （dissolved oxygen）, BOD5 （biochemical oxygen demand）, COD （chemical oxygen demand）, alkalinity, chlorides （Cl）, calcium （Ca）, sodium （Na）, magnesium （Mg）, potassium （K）, lead （Pb）, TC （total coliforms）, TF （total fecal coliforms）, and nitrate （NO3）. The goals of this study are to estimate quantities of fresh water consumption and gray water generated in typical Baghdadian households, and to investigate gray water quality （physical, chemical and biological）. The major results can be summarized as follows： （1） The daily water consumption in Baghdad ranged from 75 Lpcd to 176 Lpcd with an average of 116 Lpcd; （2） the maximum daily consumption in Baghdad ranged from 124 Lpcd to 327 Lpcd with an average of 186 Lpcd; （3） the maximum hourly consumption in Baghdad ranged from 154 Lpcd to 900 Lpcd with an average of 308 Lpcd; （4） gray water generation in Baghdad ranged from 34 Lpcd to 139 Lpcd with an average of 68 Lpcd, and that gray water generated constituted 58% to 72% of total consumption.
文摘Gastrointestinal microbiome,containing at least 100 trillion bacteria,resides in the mucosal surface of human intestine.Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases,including colon tumorigenesis.Colorectal cancer(CRC),the third most common cancer,is the disease resulting from multi-genes and multi-factors,but the mechanistic details between gut microenvironment and CRC remain poorly characterized.Thanks to new technologies such as metagenome sequencing,progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible,which has facilitated studies about microbiota composition,taxonomic alterations and host interactions.Different bacterial species and their metabolites play critical roles in the development of CRC.Also,microbiota is important in the inflammatory response and immune processes deregulation during the development and progression of CRC.This review summarizes current studies regarding the association between gastrointestinalmicrobiota and the development of CRC,which provides insights into the therapeutic strategy of CRC.
