An entomological survey of Phlebotomine sand flies (Diptera: Psychodidae) was carried out in three sectors of Foum Jamgta region (province of Azilal, Morocco) during the year 2010. Morphological identification wa...An entomological survey of Phlebotomine sand flies (Diptera: Psychodidae) was carried out in three sectors of Foum Jamgta region (province of Azilal, Morocco) during the year 2010. Morphological identification was performed on a total of 1,152 sand flies (23% females and 77% males) collected by sticky paper traps. 80% of the total collected flies were identified as Phlebotomus (Paraphlebotomus) sergenti (Parrot) (57%) and Phlebotomus (Larroussius) longicuspis (Nitzulescu) (23%). In addition to these dominant species, four other species were found, Phlebotomus (Phlebotomus) papatasi (Scopoli), Sergentomyia (Sergentomyia) minuta (Rondani), Phlebotomus (Larroussius) perniciosus (Newstead) and Phlebotomus (Paraphlebotomus) chabaudi (Croset). Overall, the population dynamics show a yearly bimodal pattern related to rainfall and temperature, and with high density around human dwellings. The spatiotemporal distribution of sand fly species was helpful to discuss strategies that might be useful in controlling cutaneous leishmaniasis transmission in this endemic focus.展开更多
In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang [symbol: see text]-[symbol: see text]) wa...In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang [symbol: see text]-[symbol: see text]) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P展开更多
The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. I...The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. In this paper, we studied the transderreal delivery capacity through mouse skin of water-soluble CdSeS quantum dots (QDs) and the deposition of these QDs in the body. QD solution was coated onto the dorsal hairless skin of male ICR mice. Fluorescence microscopy and transmission electron microscopy (TEM) were used to observe the distribution of QDs in the skin and organs, and inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure the 111Cd content to indicate the concentration of QDs in plasma and organs. Experimental results indicate that QDs can penetrate into the dermal layer and are limited to the uppermost stratum corneum layers and the hair follicles. Through blood circulation, QDs deposit mostly in liver and kidney and are difficult to clear, 111Cd concentration was greater than 14 ng g-1 in kidney after 120 h after 0.32 nmol QDs was applied to a mouse. These results suggest that QDs have in vivo transdermal delivery capacity through mouse skin and are harmful to the liver and kidney.展开更多
Objective: To evaluate the clinical efficacy of aligned acupuncture at the muscle regions plus cutaneous needle for post-stroke upper limb spasticity.Methods: By adopting a design of multicenter randomized controlled ...Objective: To evaluate the clinical efficacy of aligned acupuncture at the muscle regions plus cutaneous needle for post-stroke upper limb spasticity.Methods: By adopting a design of multicenter randomized controlled clinical trial, 488 patients with post-stroke upper limb spasticity were randomized into a treatment group and a control group, 244 in each group. In addition to rehabilitation training, the treatment group received aligned acupuncture at the muscle regions plus cutaneous needle therapy and the control group received conventional Western medicine. After successive 3-week treatments, the clinical efficacy, spasticity degree of the upper limb, joint function, and neurological defect degree were evaluated in the two groups. Results: The total effective rate was 93.4% in the treatment group versus 61.5% in the control group, and the difference was statistically significant(P < 0.05). The upper-limb spasticity degree, joint function, and neurological defect degree were improved significantly in both groups after intervention(P<0.05), and the improvements in the treatment group were more significant than those in the control group(P<0.05 or P<0.01). Conclusion: Aligned acupuncture at the muscle regions plus cutaneous needle therapy is effective in treating post-stroke upper limb spasticity.展开更多
Objective:Radiation is an important cause of delayed wound healing,and there still exist many questions regarding the patterns and mechanisms of wound healing.This study investigated the characteristics of wound heal...Objective:Radiation is an important cause of delayed wound healing,and there still exist many questions regarding the patterns and mechanisms of wound healing.This study investigated the characteristics of wound healing after varying doses of local radiation and explored possible causes of the delay in healing caused by radiation.Methods:A full-thickness dorsal longitudinal skin tissue,2 cm in diameter,was excised after local irradiation on one side of the back of swine,and the other side was wounded as a control.The size of the wound area was recorded every two days after injury.Pathological changes,proliferating cell nuclear antigen(PCNA,immunohistochemistry)and apoptosis levels(TUNEL assay)were measured at different time points after wounding.Results:The course of wound healing can be divided into four phases,namely:the arresting phase,the healing priming phase,the fast healing phase,and the healed phase.Although the total wound healing time was closely correlated to the dose of irradiation(R2=0.9758),it was more dependent on the length of the arresting phase(R2=0.9903)because once the arresting phase ended,the wound healed at a similar speed regardless of radiation doses.Pathological analysis showed that compared with the control side there were more necrotic tissues,slower epithelial crawling,as well as fewer blood vessels and cellular components in the irradiated side at the arresting phase,while other phases revealed no significant difference concerning these measurements.Immunohistochemistry showed that the irradiated wounds had significantly less PCNA-positive and more TUNEL-positive labeling of cells in the arresting phase than in other phases.Moreover,the changes were positively related to the radiation doses,but there was no obvious difference in cell proliferation or apoptosis among the healing priming phase,fast healing phase or healed phase,whether on the control side or on the irradiated side.Conclusions:After local irradiation,the length of the arresting phase determines the wound healing time.Increased apoptosis and decreased cell proliferation might be an important reason for the formation of the arresting phase.展开更多
文摘An entomological survey of Phlebotomine sand flies (Diptera: Psychodidae) was carried out in three sectors of Foum Jamgta region (province of Azilal, Morocco) during the year 2010. Morphological identification was performed on a total of 1,152 sand flies (23% females and 77% males) collected by sticky paper traps. 80% of the total collected flies were identified as Phlebotomus (Paraphlebotomus) sergenti (Parrot) (57%) and Phlebotomus (Larroussius) longicuspis (Nitzulescu) (23%). In addition to these dominant species, four other species were found, Phlebotomus (Phlebotomus) papatasi (Scopoli), Sergentomyia (Sergentomyia) minuta (Rondani), Phlebotomus (Larroussius) perniciosus (Newstead) and Phlebotomus (Paraphlebotomus) chabaudi (Croset). Overall, the population dynamics show a yearly bimodal pattern related to rainfall and temperature, and with high density around human dwellings. The spatiotemporal distribution of sand fly species was helpful to discuss strategies that might be useful in controlling cutaneous leishmaniasis transmission in this endemic focus.
文摘In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang [symbol: see text]-[symbol: see text]) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P
基金supported by the Medical College of Chinese People’s Armed Police Force in 2010 (WYZ201003)
文摘The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles; however, the permeability of the skin to these nanoparticles is currently unknown. In this paper, we studied the transderreal delivery capacity through mouse skin of water-soluble CdSeS quantum dots (QDs) and the deposition of these QDs in the body. QD solution was coated onto the dorsal hairless skin of male ICR mice. Fluorescence microscopy and transmission electron microscopy (TEM) were used to observe the distribution of QDs in the skin and organs, and inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure the 111Cd content to indicate the concentration of QDs in plasma and organs. Experimental results indicate that QDs can penetrate into the dermal layer and are limited to the uppermost stratum corneum layers and the hair follicles. Through blood circulation, QDs deposit mostly in liver and kidney and are difficult to clear, 111Cd concentration was greater than 14 ng g-1 in kidney after 120 h after 0.32 nmol QDs was applied to a mouse. These results suggest that QDs have in vivo transdermal delivery capacity through mouse skin and are harmful to the liver and kidney.
基金supported by Scientific Research Project of Hebei Provincial Administration Bureau of Traditional Chinese Medicine (No. 2009180)
文摘Objective: To evaluate the clinical efficacy of aligned acupuncture at the muscle regions plus cutaneous needle for post-stroke upper limb spasticity.Methods: By adopting a design of multicenter randomized controlled clinical trial, 488 patients with post-stroke upper limb spasticity were randomized into a treatment group and a control group, 244 in each group. In addition to rehabilitation training, the treatment group received aligned acupuncture at the muscle regions plus cutaneous needle therapy and the control group received conventional Western medicine. After successive 3-week treatments, the clinical efficacy, spasticity degree of the upper limb, joint function, and neurological defect degree were evaluated in the two groups. Results: The total effective rate was 93.4% in the treatment group versus 61.5% in the control group, and the difference was statistically significant(P < 0.05). The upper-limb spasticity degree, joint function, and neurological defect degree were improved significantly in both groups after intervention(P<0.05), and the improvements in the treatment group were more significant than those in the control group(P<0.05 or P<0.01). Conclusion: Aligned acupuncture at the muscle regions plus cutaneous needle therapy is effective in treating post-stroke upper limb spasticity.
文摘Objective:Radiation is an important cause of delayed wound healing,and there still exist many questions regarding the patterns and mechanisms of wound healing.This study investigated the characteristics of wound healing after varying doses of local radiation and explored possible causes of the delay in healing caused by radiation.Methods:A full-thickness dorsal longitudinal skin tissue,2 cm in diameter,was excised after local irradiation on one side of the back of swine,and the other side was wounded as a control.The size of the wound area was recorded every two days after injury.Pathological changes,proliferating cell nuclear antigen(PCNA,immunohistochemistry)and apoptosis levels(TUNEL assay)were measured at different time points after wounding.Results:The course of wound healing can be divided into four phases,namely:the arresting phase,the healing priming phase,the fast healing phase,and the healed phase.Although the total wound healing time was closely correlated to the dose of irradiation(R2=0.9758),it was more dependent on the length of the arresting phase(R2=0.9903)because once the arresting phase ended,the wound healed at a similar speed regardless of radiation doses.Pathological analysis showed that compared with the control side there were more necrotic tissues,slower epithelial crawling,as well as fewer blood vessels and cellular components in the irradiated side at the arresting phase,while other phases revealed no significant difference concerning these measurements.Immunohistochemistry showed that the irradiated wounds had significantly less PCNA-positive and more TUNEL-positive labeling of cells in the arresting phase than in other phases.Moreover,the changes were positively related to the radiation doses,but there was no obvious difference in cell proliferation or apoptosis among the healing priming phase,fast healing phase or healed phase,whether on the control side or on the irradiated side.Conclusions:After local irradiation,the length of the arresting phase determines the wound healing time.Increased apoptosis and decreased cell proliferation might be an important reason for the formation of the arresting phase.