保留比率肺功能减损(preserved ratio impaired spirometry, PRISm)定义为在吸入支气管扩张剂后,FEV1/FVC ≥ 0.7,FEV1% Preserved ratio impaired spirometry (PRISm) is a heterogeneous lung disease, defined by after bronchodilat...保留比率肺功能减损(preserved ratio impaired spirometry, PRISm)定义为在吸入支气管扩张剂后,FEV1/FVC ≥ 0.7,FEV1% Preserved ratio impaired spirometry (PRISm) is a heterogeneous lung disease, defined by after bronchodilator inhalation a forced expiratory volume in one second (FEV1) that is less than 80% of the predicted value, whilst maintaining FEV1/forced vital capacity (FVC) ≥ 0.7. In recent years, although the prevalence of PRISm in the population has been confirmed by some studies, in-depth discussion and research in related fields are still insufficient. Previous studies have found that PRISm population can be caused by a variety of risk factors. And compared with those with normal lung function, the risk of progression to the COPD, the risk of cardiovascular-related mortality and all-cause mortality is significantly increased. Without timely intervention, it may gradually deteriorate to COPD. So it is very important to detect and prevent PRISm early. This review encapsulates research pertaining to PRISm, spanning its incidence, risk factors, disease characteristics, associated diseases, prognosis and treatment, aiming to understand PRISm comprehensively, and hope to provide more accurate condition assessment for PRISm patients, and promote the comprehensive rehabilitation and health management of patients.展开更多
保留比值受损肺功能(preserved ratio impaired spirometry,PRISm)描述了一种较为普遍的肺功能障碍,近年来被认为是慢性阻塞性肺疾病(简称慢阻肺)的前期,目前人们对PRISm的病因、流行病学、临床特征有了具体的认识,但其发病机制、疾病...保留比值受损肺功能(preserved ratio impaired spirometry,PRISm)描述了一种较为普遍的肺功能障碍,近年来被认为是慢性阻塞性肺疾病(简称慢阻肺)的前期,目前人们对PRISm的病因、流行病学、临床特征有了具体的认识,但其发病机制、疾病异质性和预后仍未研究清楚;嗜酸性粒细胞(eosinophils,EOS)是慢阻肺气道炎症的重要参与者,对于慢阻肺的诊疗指导作用不容小觑。近年来有研究发现,EOS与PRISm同样具有相关性,本文系统阐述了EOS在PRISm发生发展中作用的研究进展,以及在PRISm中的临床诊疗和预后价值,为慢阻肺的早期管理和诊治提供新的思路。展开更多
文摘保留比率肺功能减损(preserved ratio impaired spirometry, PRISm)定义为在吸入支气管扩张剂后,FEV1/FVC ≥ 0.7,FEV1% Preserved ratio impaired spirometry (PRISm) is a heterogeneous lung disease, defined by after bronchodilator inhalation a forced expiratory volume in one second (FEV1) that is less than 80% of the predicted value, whilst maintaining FEV1/forced vital capacity (FVC) ≥ 0.7. In recent years, although the prevalence of PRISm in the population has been confirmed by some studies, in-depth discussion and research in related fields are still insufficient. Previous studies have found that PRISm population can be caused by a variety of risk factors. And compared with those with normal lung function, the risk of progression to the COPD, the risk of cardiovascular-related mortality and all-cause mortality is significantly increased. Without timely intervention, it may gradually deteriorate to COPD. So it is very important to detect and prevent PRISm early. This review encapsulates research pertaining to PRISm, spanning its incidence, risk factors, disease characteristics, associated diseases, prognosis and treatment, aiming to understand PRISm comprehensively, and hope to provide more accurate condition assessment for PRISm patients, and promote the comprehensive rehabilitation and health management of patients.
文摘保留比值受损肺功能(preserved ratio impaired spirometry,PRISm)描述了一种较为普遍的肺功能障碍,近年来被认为是慢性阻塞性肺疾病(简称慢阻肺)的前期,目前人们对PRISm的病因、流行病学、临床特征有了具体的认识,但其发病机制、疾病异质性和预后仍未研究清楚;嗜酸性粒细胞(eosinophils,EOS)是慢阻肺气道炎症的重要参与者,对于慢阻肺的诊疗指导作用不容小觑。近年来有研究发现,EOS与PRISm同样具有相关性,本文系统阐述了EOS在PRISm发生发展中作用的研究进展,以及在PRISm中的临床诊疗和预后价值,为慢阻肺的早期管理和诊治提供新的思路。
