Objective: To study vascular characteristics of bronchial arterial reconstruction for lung cancer in relation to patient’s prognosis.Methods: According to the International Staging System for Lung Cancer, bronchial a...Objective: To study vascular characteristics of bronchial arterial reconstruction for lung cancer in relation to patient’s prognosis.Methods: According to the International Staging System for Lung Cancer, bronchial arteriography was performed in 16 patients with stage III a , 42 patients with stage III b lung cancer before bronchial arterial infusion (BAI) of chemotherapy. Angiograms was read by radiologists and analyzed by real-multicolour picture system. All patients were followed up and the data were collected.Results: The common findings of angiographic vessels were variable distending, hypervascularity with shunting as net, and extravasation of contrast, light or dense staining in the regions of the tumors for all patients. Radial growth vessels in pericancer were found in 30 patients, including 20 cases (66.7%) of small cell lung cancer (SCLC), 7 cases (23.3%) of adenocarcinoma, 3 cases (10%) of squamous carcinoma; a thick circular vessels in pericancer in 16 patients: both characteristics above were seen in 5 cases. Hematogenous dissemination was found in 19 of 30 patients (63.3%) with radial growth vessels in pericancer; lymphatic spread (supraclavicular nodes) in 3 of 30 (10%); local recurrences in 2 of 30 (6.7%) 6 and 30 months respectively after curable resection. Hematogenous dissemination was found in 2 of 28 patients (7.1%) without radial growth vessels in pericancer during the period of follow-up. There was significant difference in the rate of hematogenous dissemination in two groups (P<0.01).Conclusion: Radial growth vessels at pericancer for bronchial arteriography of lung cancer was an important sign of high rate of hematogenous dissemination and lymphatic spread. Key words lung cancer - angiography - metastasis展开更多
Objective： To establish the animal model for the chronic pulmonary embolism and do some research on it. Methods： Pulmonary arteriography by DSA were performed in 6 goats and the stent was released in the infer-pulmo...Objective： To establish the animal model for the chronic pulmonary embolism and do some research on it. Methods： Pulmonary arteriography by DSA were performed in 6 goats and the stent was released in the infer-pulmonary arterary. Arterial blood gas analysis and right heart catheterization were done. After 3 days of embolism, pulmonary arteriography were performed again. After the animal was sacrificed, the right and left infer-pulmonary tissues were prepared and pathologically studied. Results： Stents were smoothly released in 6 animals. Compared with that before embolism, the arterial blood gas showed no difference 10 minutes later and 3 days later of the stent released. The pulmonary angiography showed that the right infra pulmonary artery was partly blocked and the blood could still pass by. 3 d of the embolism later, the stent was placed well and the right pulmonary artery was completely blocked. Compared with that before embolism,the right atrial pressure, ventricular pressure and the pulmonary pressure in 10 rain after embolism did not change much （ P 〉 0.05 ）, while 3 d after embolism, the pressures were obviously changed（P 〈 0.05 ）. There was no atelectasis ,pleural effusion in the right infra lobe in the experimental group. The wall of blood capillary among the alve- olar wall were significantly dilated. Hyperemia and edema were also observed. Lots of monocyte infiltrated. Localized exudates appeared in alveolar. Conclusion： By releasing stent in the pulmonary, the chronic pulmonary embolism model could be established in the animal experiment, and it should have great potential value in the following study.展开更多
文摘Objective: To study vascular characteristics of bronchial arterial reconstruction for lung cancer in relation to patient’s prognosis.Methods: According to the International Staging System for Lung Cancer, bronchial arteriography was performed in 16 patients with stage III a , 42 patients with stage III b lung cancer before bronchial arterial infusion (BAI) of chemotherapy. Angiograms was read by radiologists and analyzed by real-multicolour picture system. All patients were followed up and the data were collected.Results: The common findings of angiographic vessels were variable distending, hypervascularity with shunting as net, and extravasation of contrast, light or dense staining in the regions of the tumors for all patients. Radial growth vessels in pericancer were found in 30 patients, including 20 cases (66.7%) of small cell lung cancer (SCLC), 7 cases (23.3%) of adenocarcinoma, 3 cases (10%) of squamous carcinoma; a thick circular vessels in pericancer in 16 patients: both characteristics above were seen in 5 cases. Hematogenous dissemination was found in 19 of 30 patients (63.3%) with radial growth vessels in pericancer; lymphatic spread (supraclavicular nodes) in 3 of 30 (10%); local recurrences in 2 of 30 (6.7%) 6 and 30 months respectively after curable resection. Hematogenous dissemination was found in 2 of 28 patients (7.1%) without radial growth vessels in pericancer during the period of follow-up. There was significant difference in the rate of hematogenous dissemination in two groups (P<0.01).Conclusion: Radial growth vessels at pericancer for bronchial arteriography of lung cancer was an important sign of high rate of hematogenous dissemination and lymphatic spread. Key words lung cancer - angiography - metastasis
基金supported financially by the Youth Scholar Foundation of city health administration of shanghai(No044Y02)
文摘Objective： To establish the animal model for the chronic pulmonary embolism and do some research on it. Methods： Pulmonary arteriography by DSA were performed in 6 goats and the stent was released in the infer-pulmonary arterary. Arterial blood gas analysis and right heart catheterization were done. After 3 days of embolism, pulmonary arteriography were performed again. After the animal was sacrificed, the right and left infer-pulmonary tissues were prepared and pathologically studied. Results： Stents were smoothly released in 6 animals. Compared with that before embolism, the arterial blood gas showed no difference 10 minutes later and 3 days later of the stent released. The pulmonary angiography showed that the right infra pulmonary artery was partly blocked and the blood could still pass by. 3 d of the embolism later, the stent was placed well and the right pulmonary artery was completely blocked. Compared with that before embolism,the right atrial pressure, ventricular pressure and the pulmonary pressure in 10 rain after embolism did not change much （ P 〉 0.05 ）, while 3 d after embolism, the pressures were obviously changed（P 〈 0.05 ）. There was no atelectasis ,pleural effusion in the right infra lobe in the experimental group. The wall of blood capillary among the alve- olar wall were significantly dilated. Hyperemia and edema were also observed. Lots of monocyte infiltrated. Localized exudates appeared in alveolar. Conclusion： By releasing stent in the pulmonary, the chronic pulmonary embolism model could be established in the animal experiment, and it should have great potential value in the following study.
