目的探讨乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期患者对其肺表面生化标志物水平、气道重塑以及肺功能水平产生的影响。方法选取2020年2月—2022年4月江南大学附属医院的60例慢性阻塞性肺疾病急性加重期患者为研究对象;以投掷硬币...目的探讨乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期患者对其肺表面生化标志物水平、气道重塑以及肺功能水平产生的影响。方法选取2020年2月—2022年4月江南大学附属医院的60例慢性阻塞性肺疾病急性加重期患者为研究对象;以投掷硬币法分为参照组和研究组,参照组(30例)施以常规对症治疗;研究组(30例)在参照组基础上,施以乙酰半胱氨酸治疗;对比两组患者肺表面生化标志物水平、气道重塑以及肺功能水平。结果治疗后,研究组血清肺表面活性蛋白(pulmonary surfatcant-associated protein,SP)-A、克拉拉细胞蛋白16(clara cell secretory protein 16,CC16)、SP-D水平相较于参照组显著降低,差异有统计学意义(P<0.05)。治疗后,研究组气道壁面积(area of airway wall,WA)、气道壁厚度同气道管腔外径比值(airway wall thickness/diameter ofairway,T/D)、气道腔面积(area of airway,AI)、WA占总截面积百分比(wall area percent,WA%)相较于参照组低,差异有统计学意义(P<0.05)。治疗后,研究组用力肺活量(forced vital capacity,FVC)为(2.51±0.51)L、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)为(2.35±0.49)L、FEV1/FVC为(95.22±0.72)%明显高于参照组,差异有统计学意义(t=3.071、2.555、16.182,P<0.05)。结论临床对慢性阻塞性肺疾病急性加重期患者采用乙酰半胱氨酸完成治疗后,对于肺表面生化标志物水平、气道重塑以及肺功能水平的改善,可以获得显著效果。展开更多
目的:观察金龙蛤蚧平喘加味方对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期肺肾气虚证合并骨质疏松患者骨密度(bone mineral density,BMD)及骨代谢生化标志物的影响。方法:选取2022年9月至2023年8月安徽中医...目的:观察金龙蛤蚧平喘加味方对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期肺肾气虚证合并骨质疏松患者骨密度(bone mineral density,BMD)及骨代谢生化标志物的影响。方法:选取2022年9月至2023年8月安徽中医药大学附属滁州中西医结合医院呼吸科门诊及病房收治的COPD稳定期肺肾气虚证合并OP患者58例,根据随机数字表法分为对照组和联合组,每组29例。对照组给予常规西药对症治疗,联合组在对照组治疗的基础上联合金龙蛤蚧平喘加味方治疗。观察两组患者治疗前后肺功能[1秒用力呼气容积(forced expiratory volume in one second,FEV1)用力肺活量(forced vital capacity,FVC)、FEV1/FVC]、COPD评估测试问卷(COPD assessment test,CAT)评分、症状积分、BMD及骨代谢生化标志物[总碱性磷酸酶(alkaline phosphatase,ALP)、骨钙素(osteocalcin,OC)及Ⅰ型胶原C端肽(C-terminal peptide of type 1 collagen,CTX-1)]等指标变化情况。结果:联合组治疗后腰椎BMD高于对照组,差异有统计学意义(P<0.05),股骨颈BMD高于对照组,差异无统计学意义(P>0.05);联合组治疗后ALP、OC、CTX-1水平低于对照组,差异有统计学意义(P<0.05);联合组治疗后腰背疼痛、腰膝酸软、下肢抽筋症状积分均低于对照组,差异有统计学意义(P<0.05);联合组治疗后FEV1高于对照组,CAT评分低于对照组,差异有统计学意义(P<0.05)。结论:金龙蛤蚧平喘加味方能改善COPD稳定期肺肾气虚证合并骨质疏松患者的骨密度、肺功能,降低骨代谢生化标志物ALP、OC、CTX-1水平,减轻患者腰背疼痛、腰膝酸软、下肢抽筋症状。展开更多
Context: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary art...Context: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease. Objectiv e: To determine if there are novel patterns of lipoprotein heterogeneity in low -birth-weight infants. Design, Setting, and Participants: Prospective study at a US medical center of a representative sample of infants (n = 163; 70 white an d 93 black) born at 28 or more weeks of gestational age between January 3, 2000, and September 27, 2000. This sample constituted 20%of all infants born during the study period at this site. Main Outcome Measures: Plasma levels and particle sizes of lipoprotein subclasses and plasma concentrations of lipids, lipoprotei ns (high-density lipoprotein [HDL] and low-density lipoprotein [LDL]), and apo lipoproteins. Results: An elevated lipoprotein peak of a particle with density b etween 1.062 and 1.072 g/mL was identified using physical-chemical methods. Thi s subclass of large HDL was enriched in apolipoprotein C-I (apo C-I). Based on the amount of the apo C-I-enriched HDL peak, 156 infants were assigned to 1 o f 4 groups: 0 (none detected), 17%; 1 (possibly pre sent), 41%; 2 (probably present), 22%; 3 (elevated), 19%. Infants in group 3, compared with those in the other 3 groups, had significantly (P<.001) lower m ean birth weight (2683.7 vs 3307.1 g)-and younger mean gestational age (36.2 vs 39.3 wk). After correction for age, infants in group 3 had signifi-cantly high er levels of total and large HDL cholesterol and of total and large LDL choleste rol and LDL particle number. However, infants in group 3 had lower levels of sma ll HDL, very low-density lipoproteins, and triglycerides than infants in the ot her 3 groups. This lipoprotein profile differed from that in infants born small for gestational age, who had significantly higher triglyceride (P<.001) and apo B (P=.04) levels, but lower levels of total and large HDL cholesterol (P < .001) and apo A-I (P<.001). Conclusions Because apo C-I-enriched HDL, and purified apo C-I alone, promotes apoptosis in vitro, increased amounts of this particle may have physiological significance and identify a novel group of low-birth-w eight infants apparently distinct from traditionally classified small-for-gest ationalage infants.展开更多
文摘目的探讨乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期患者对其肺表面生化标志物水平、气道重塑以及肺功能水平产生的影响。方法选取2020年2月—2022年4月江南大学附属医院的60例慢性阻塞性肺疾病急性加重期患者为研究对象;以投掷硬币法分为参照组和研究组,参照组(30例)施以常规对症治疗;研究组(30例)在参照组基础上,施以乙酰半胱氨酸治疗;对比两组患者肺表面生化标志物水平、气道重塑以及肺功能水平。结果治疗后,研究组血清肺表面活性蛋白(pulmonary surfatcant-associated protein,SP)-A、克拉拉细胞蛋白16(clara cell secretory protein 16,CC16)、SP-D水平相较于参照组显著降低,差异有统计学意义(P<0.05)。治疗后,研究组气道壁面积(area of airway wall,WA)、气道壁厚度同气道管腔外径比值(airway wall thickness/diameter ofairway,T/D)、气道腔面积(area of airway,AI)、WA占总截面积百分比(wall area percent,WA%)相较于参照组低,差异有统计学意义(P<0.05)。治疗后,研究组用力肺活量(forced vital capacity,FVC)为(2.51±0.51)L、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)为(2.35±0.49)L、FEV1/FVC为(95.22±0.72)%明显高于参照组,差异有统计学意义(t=3.071、2.555、16.182,P<0.05)。结论临床对慢性阻塞性肺疾病急性加重期患者采用乙酰半胱氨酸完成治疗后,对于肺表面生化标志物水平、气道重塑以及肺功能水平的改善,可以获得显著效果。
文摘目的:观察金龙蛤蚧平喘加味方对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期肺肾气虚证合并骨质疏松患者骨密度(bone mineral density,BMD)及骨代谢生化标志物的影响。方法:选取2022年9月至2023年8月安徽中医药大学附属滁州中西医结合医院呼吸科门诊及病房收治的COPD稳定期肺肾气虚证合并OP患者58例,根据随机数字表法分为对照组和联合组,每组29例。对照组给予常规西药对症治疗,联合组在对照组治疗的基础上联合金龙蛤蚧平喘加味方治疗。观察两组患者治疗前后肺功能[1秒用力呼气容积(forced expiratory volume in one second,FEV1)用力肺活量(forced vital capacity,FVC)、FEV1/FVC]、COPD评估测试问卷(COPD assessment test,CAT)评分、症状积分、BMD及骨代谢生化标志物[总碱性磷酸酶(alkaline phosphatase,ALP)、骨钙素(osteocalcin,OC)及Ⅰ型胶原C端肽(C-terminal peptide of type 1 collagen,CTX-1)]等指标变化情况。结果:联合组治疗后腰椎BMD高于对照组,差异有统计学意义(P<0.05),股骨颈BMD高于对照组,差异无统计学意义(P>0.05);联合组治疗后ALP、OC、CTX-1水平低于对照组,差异有统计学意义(P<0.05);联合组治疗后腰背疼痛、腰膝酸软、下肢抽筋症状积分均低于对照组,差异有统计学意义(P<0.05);联合组治疗后FEV1高于对照组,CAT评分低于对照组,差异有统计学意义(P<0.05)。结论:金龙蛤蚧平喘加味方能改善COPD稳定期肺肾气虚证合并骨质疏松患者的骨密度、肺功能,降低骨代谢生化标志物ALP、OC、CTX-1水平,减轻患者腰背疼痛、腰膝酸软、下肢抽筋症状。
文摘Context: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease. Objectiv e: To determine if there are novel patterns of lipoprotein heterogeneity in low -birth-weight infants. Design, Setting, and Participants: Prospective study at a US medical center of a representative sample of infants (n = 163; 70 white an d 93 black) born at 28 or more weeks of gestational age between January 3, 2000, and September 27, 2000. This sample constituted 20%of all infants born during the study period at this site. Main Outcome Measures: Plasma levels and particle sizes of lipoprotein subclasses and plasma concentrations of lipids, lipoprotei ns (high-density lipoprotein [HDL] and low-density lipoprotein [LDL]), and apo lipoproteins. Results: An elevated lipoprotein peak of a particle with density b etween 1.062 and 1.072 g/mL was identified using physical-chemical methods. Thi s subclass of large HDL was enriched in apolipoprotein C-I (apo C-I). Based on the amount of the apo C-I-enriched HDL peak, 156 infants were assigned to 1 o f 4 groups: 0 (none detected), 17%; 1 (possibly pre sent), 41%; 2 (probably present), 22%; 3 (elevated), 19%. Infants in group 3, compared with those in the other 3 groups, had significantly (P<.001) lower m ean birth weight (2683.7 vs 3307.1 g)-and younger mean gestational age (36.2 vs 39.3 wk). After correction for age, infants in group 3 had signifi-cantly high er levels of total and large HDL cholesterol and of total and large LDL choleste rol and LDL particle number. However, infants in group 3 had lower levels of sma ll HDL, very low-density lipoproteins, and triglycerides than infants in the ot her 3 groups. This lipoprotein profile differed from that in infants born small for gestational age, who had significantly higher triglyceride (P<.001) and apo B (P=.04) levels, but lower levels of total and large HDL cholesterol (P < .001) and apo A-I (P<.001). Conclusions Because apo C-I-enriched HDL, and purified apo C-I alone, promotes apoptosis in vitro, increased amounts of this particle may have physiological significance and identify a novel group of low-birth-w eight infants apparently distinct from traditionally classified small-for-gest ationalage infants.
