目的 评价脾氨肽口服溶液治疗季节性过敏性鼻炎的有效性和安全性。方法 选取84例季节性过敏性鼻炎患者,随机分配至脾氨肽组和常规组。两组各服药4周,治疗后比较临床疗效、生活质量和外周血免疫功能的变化,并同时进行安全性评估。结果 ...目的 评价脾氨肽口服溶液治疗季节性过敏性鼻炎的有效性和安全性。方法 选取84例季节性过敏性鼻炎患者,随机分配至脾氨肽组和常规组。两组各服药4周,治疗后比较临床疗效、生活质量和外周血免疫功能的变化,并同时进行安全性评估。结果 治疗后脾氨肽组鼻部症状较常规组明显减轻(1.1±1.0 vs 1.9±1.7,P=0.046);生活质量较常规组明显改善(15.4±18.7 vs 19.0±18.3,P=0.096);细胞因子IL-17A较常规组升高(1.7±1.2 vs 3.9±6.1,P=0.012);抗组胺药物、鼻用糖皮质激素用量较常规组显著减少(P<0.05)。结论 脾氨肽口服溶液联合常规药物剂治疗季节性过敏性鼻炎可以减轻鼻部症状,改善生活质量,减少药物用量,发挥免疫调节作用。展开更多
All-atom molecular simulations and two-dimensional nuclear overhauser effect spectrum have been used to study the conformations of carnosine in aqueous solution. Intramolecular distances, root-mean-square deviation, r...All-atom molecular simulations and two-dimensional nuclear overhauser effect spectrum have been used to study the conformations of carnosine in aqueous solution. Intramolecular distances, root-mean-square deviation, radius of gyration, and solvent-accessible surface are used to characterize the properties of the carnosine. Carnosine can shift between extended and folded states, but exists mostly in extended state in water. Its preference for extension in pure water has been proven by the 2D nuclear magnetic resonance (NMR) experiment. The NMR experimental results are consistent with the molecular dynamics simulations.展开更多
Densities of aqueous solutions of eight amino acids, glycine, L-alanine, L-valine, L-isoleucine, L-serine, L-threonine, L-arginine and L-phenylalanine, are measured as a function of amino acid concentration from 293.1...Densities of aqueous solutions of eight amino acids, glycine, L-alanine, L-valine, L-isoleucine, L-serine, L-threonine, L-arginine and L-phenylalanine, are measured as a function of amino acid concentration from 293.15K to 333.15K. These data are used to calculate the apparent molar volume Vφ and infinite dilution apparent molar volume Vφo (partial molar volume). Data of five amino acids are used to correlate partial molar volume Vφo usinggroup contribution method to estimate the contributions of the zwitterionic end groups (NH3+,COO-) and CH2 group, OH group, CNHNHNH2 group and C6H5(phenyl) group of amino acids. The results show that Vφo values for all kinds of groups of amino acids studied increase with increase of temperature except those for CH2 group, which are almost constant within the studied temperature range. Data of other amino acids, L-valine, L-isoleucine and L-threonine, are chosen for comparison with the predicted partial molar volume Vφo using the group additivity parameters obtained. The results confirm that this group additivity method has excellent predictive utility.展开更多
文摘目的 评价脾氨肽口服溶液治疗季节性过敏性鼻炎的有效性和安全性。方法 选取84例季节性过敏性鼻炎患者,随机分配至脾氨肽组和常规组。两组各服药4周,治疗后比较临床疗效、生活质量和外周血免疫功能的变化,并同时进行安全性评估。结果 治疗后脾氨肽组鼻部症状较常规组明显减轻(1.1±1.0 vs 1.9±1.7,P=0.046);生活质量较常规组明显改善(15.4±18.7 vs 19.0±18.3,P=0.096);细胞因子IL-17A较常规组升高(1.7±1.2 vs 3.9±6.1,P=0.012);抗组胺药物、鼻用糖皮质激素用量较常规组显著减少(P<0.05)。结论 脾氨肽口服溶液联合常规药物剂治疗季节性过敏性鼻炎可以减轻鼻部症状,改善生活质量,减少药物用量,发挥免疫调节作用。
文摘All-atom molecular simulations and two-dimensional nuclear overhauser effect spectrum have been used to study the conformations of carnosine in aqueous solution. Intramolecular distances, root-mean-square deviation, radius of gyration, and solvent-accessible surface are used to characterize the properties of the carnosine. Carnosine can shift between extended and folded states, but exists mostly in extended state in water. Its preference for extension in pure water has been proven by the 2D nuclear magnetic resonance (NMR) experiment. The NMR experimental results are consistent with the molecular dynamics simulations.
基金the Educational Department Doctor Foundation of China (No. 2000005608).
文摘Densities of aqueous solutions of eight amino acids, glycine, L-alanine, L-valine, L-isoleucine, L-serine, L-threonine, L-arginine and L-phenylalanine, are measured as a function of amino acid concentration from 293.15K to 333.15K. These data are used to calculate the apparent molar volume Vφ and infinite dilution apparent molar volume Vφo (partial molar volume). Data of five amino acids are used to correlate partial molar volume Vφo usinggroup contribution method to estimate the contributions of the zwitterionic end groups (NH3+,COO-) and CH2 group, OH group, CNHNHNH2 group and C6H5(phenyl) group of amino acids. The results show that Vφo values for all kinds of groups of amino acids studied increase with increase of temperature except those for CH2 group, which are almost constant within the studied temperature range. Data of other amino acids, L-valine, L-isoleucine and L-threonine, are chosen for comparison with the predicted partial molar volume Vφo using the group additivity parameters obtained. The results confirm that this group additivity method has excellent predictive utility.