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黄葵胶囊防治顺铂相关性肾毒性的临床观察 被引量:4
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作者 韩灵敏 韩春山 +2 位作者 杜利力 于晓丽 段孝楠 《广西医科大学学报》 CAS 2012年第2期279-280,共2页
目的:观察黄葵胶囊防治顺铂相关性肾毒性的效果。方法:选取我科2006年1月至2011年10月既往有化学性肾功损伤现已基本恢复并排除原发性肾脏疾病患者68例进行观察,将其按数字表法随机分为观察组和对照组,各34例。两组患者性别、年龄、化... 目的:观察黄葵胶囊防治顺铂相关性肾毒性的效果。方法:选取我科2006年1月至2011年10月既往有化学性肾功损伤现已基本恢复并排除原发性肾脏疾病患者68例进行观察,将其按数字表法随机分为观察组和对照组,各34例。两组患者性别、年龄、化疗前肾功情况均无显著差异(P>0.05),均应用含标准剂量顺铂方案进行化疗。观察组同步口服黄葵胶囊,对照组单纯化疗,治疗期间两组定期监测肾功。化疗后1个月比较两组患者血清肌酐水平(Scr)、肌酐清除率(Ccr)、胱抑素C(CysC)、尿β2-MG值变化情况。结果:化疗后观察组患者各监测指标数值变化幅度,即肾功损伤情况均较对照组轻(P<0.05)。结论:黄葵胶囊在含顺铂方案化疗过程中可对患者肾功有保护作用,能够减轻顺铂的肾毒性。 展开更多
关键词 黄葵胶囊 顺铂 化疗 肾功损伤
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Role of BMP-7 and TGF-β_1 expression in renal tubulo-interstitial lesion of Wistar rats induced by unilateral ureteral obstruction
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作者 周剑锋 李娜 袁发焕 《Journal of Medical Colleges of PLA(China)》 CAS 2005年第6期333-337,共5页
Objective: To explore the role of bone morphorgenetic protein-7 (BMP-7) in the renal tubulo-interstitial lesions induced by unilateral ureteral obstruction (UUO). Methods: Sixty Wistar rats were equally and random... Objective: To explore the role of bone morphorgenetic protein-7 (BMP-7) in the renal tubulo-interstitial lesions induced by unilateral ureteral obstruction (UUO). Methods: Sixty Wistar rats were equally and randomly divided into normal control, sham operation and UUO groups, and respectively sacrificed on the 1st, 3rd, 7th, 14th day after the time of UUO operation. The mRNA levels of BMP-7 and TGF-β1 in the renal tissues were examined by RT-PCR. The expression sites and levels of BMP-7 and TGF-β1 proteins were detected by immunohistochemistry staining. Results:Compared to control groups, the level of BMP-7 mRNA was significantly decreased, but that of TGF-β1 mRNA was significantly increased in UUO rats. Immunohistochemistry staining indicated that BMP-7 mainly expressed in the renal tubules and interstitum, rarely in the glomeruli. In UUO rats, the expression of BMP-7 protein was decreased, but that of TGF-β1 was increased in an obstruction dependent manner. Conclusion:The down- regulation of BMP-7 is observed in the early phase of fibrotic process of the renal interstitium, suggesting it may be involved in the formation and development of the tubulo-interstitial lesions. 展开更多
关键词 bone morphogenetic protein-7 unilateral ureteral obstruction FIBROSIS
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Ketamine Abuse-Induced Obstructive Nephropathy and Kidney Injury
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作者 Jun Wang Hua-lin Qi +1 位作者 Feng Liu Hai-dong Yan 《Chinese Medical Sciences Journal》 CAS CSCD 2014年第2期122-124,共3页
KETAMINE is an anaesthetic agent characterized by a rapid onset and short duration of action, but it has increasingly been abused as a "clubdrug" since the late 1980s. It can causeinflammation and contraction of the... KETAMINE is an anaesthetic agent characterized by a rapid onset and short duration of action, but it has increasingly been abused as a "clubdrug" since the late 1980s. It can causeinflammation and contraction of the bladder, leading to possibly irreversible kidney damage. Since 2007, case reports are appearing in the medical literature describing severe bladder dysfunction and kidney injury in ketamine abusers. In this article, we report a case of obstructive nephropathy and kidney injury in a ketamine abuser. 展开更多
关键词 KETAMINE kidney injury HYDRONEPHROSIS
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奥普利农与米力农在新生儿先心病双心室纠治术后效果的比较
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作者 黄红娟 李炘 +6 位作者 沈维嘉 袁洪樑 沈啸威 冉旭东 廖健毅 徐贵英 徐婉玉 《中华胸心血管外科杂志》 CSCD 北大核心 2023年第11期647-652,共6页
目的回顾性比较PDE3抑制剂奥普利农和米力农的临床疗效。方法收集2018至2022年苏州大学附属儿童医院心胸外科体外循环下新生儿先心病双心室纠治术后患儿41例,其中奥普利农组25例,米力农组16例,总结并研究患儿肾功能、心脏功能改善及心... 目的回顾性比较PDE3抑制剂奥普利农和米力农的临床疗效。方法收集2018至2022年苏州大学附属儿童医院心胸外科体外循环下新生儿先心病双心室纠治术后患儿41例,其中奥普利农组25例,米力农组16例,总结并研究患儿肾功能、心脏功能改善及心律失常发生率。结果两组术后1天射血分数(EF)均下降(P<0.01);术后4天奥普利农组EF较术后1天显著升高(P<0.01),米力农组较术后1天升高(P<0.05),且同期奥普利农组EF较米力农组显著升高(P<0.01);米力农组术后7天EF较术后4天继续升高(P<0.01),但两组间比较差异无统计学意义;远期随访发现奥普利农组术后7天EF较远期差异无统计学意义(P>0.05),而米力农组远期EF高于术后7天(P<0.05)。奥普力农组术后4、7天肌酐水平持续下降(P<0.01,P<0.05);米力农组术后4天较术后1天肌酐水平下降显著(P<0.01),术后7天较术后4天下降不明显;术后7天奥普利农组肌酐水平较米力农组更低(P<0.05)。患儿心律失常发生率奥普利农组比值稍降;而米力农组无变化。结论奥普利农改善新生儿先心病双心室纠治术后心功能效果优于米力农,且恢复至正常心功能时间更短;在肾功能保护方面,奥普利农强于米力农,且奥普利农对于肾脏保护作用持续时间较长;心律失常发生率方面两种药物差异无统计学意义。 展开更多
关键词 先天性心脏病 奥普利农 米力农 新生儿 能不全 急性肾功损伤
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