本文报道了1例临床上罕见的前列腺癌肾脏转移病例。67岁男性患者,体检发现总前列腺特异性抗原(total prostate specific antigen,tPSA)升高,为19.7 ng/mL,游离前列腺特异性抗原(free prostate specific antigen,fPSA)/tPSA为0.06,外院...本文报道了1例临床上罕见的前列腺癌肾脏转移病例。67岁男性患者,体检发现总前列腺特异性抗原(total prostate specific antigen,tPSA)升高,为19.7 ng/mL,游离前列腺特异性抗原(free prostate specific antigen,fPSA)/tPSA为0.06,外院前列腺穿刺活检确诊前列腺癌后于2023年7月至我院就诊,Gleason评分4+4=8分,前列腺MRI检查示周围带左后份DWI信号增高,邻近结构未见浸润,盆腔未见肿大淋巴结,全身骨显像检查未见明确肿瘤骨转移病灶,门诊诊断前列腺癌(T2cN0M0,高危),肾脏增强CT示右肾下份包膜下肾皮质区囊实性占位伴周围渗出,大小约6.3 cm×3.5 cm。多学科讨论后行超声引导下肾穿刺,病理结果显示符合前列腺癌转移,后予药物去势联合阿比特龙和泼尼松治疗。治疗1个月后复查PSA为7.2 ng/mL,睾酮为0.49μg/L。患者确诊2个月后,因个人原因拒绝进一步治疗,绝食后死亡。展开更多
Case ReportIn August 2004, a 76-year-old patient was referred to our hospital for progressive loss of appetite, accompanied with mild upper abdominal distention, pain, hiccups and dyspepsia over a recent 3 months peri...Case ReportIn August 2004, a 76-year-old patient was referred to our hospital for progressive loss of appetite, accompanied with mild upper abdominal distention, pain, hiccups and dyspepsia over a recent 3 months period. Reviewing his disease history showed that 16 months before admission （April 2003）, he was diagnosed with a recurring left renal clear cell cancer （immunohistochemical staining of tumor cells were positive for CK and Vim, but negative for SMA, HMB-45 and HHF-35, Fig. 1） 10 years after a nephrectomy due to a right renal cancer. At that time, he was treated with photodynamic therapy followed by bio-immunotherapy（interleukine-2 plus lymphokine-activated killer cells）. Follow-up by an abdominal CT scan every 3 months showed significant regression of the left renal carcinoma.展开更多
文摘Case ReportIn August 2004, a 76-year-old patient was referred to our hospital for progressive loss of appetite, accompanied with mild upper abdominal distention, pain, hiccups and dyspepsia over a recent 3 months period. Reviewing his disease history showed that 16 months before admission （April 2003）, he was diagnosed with a recurring left renal clear cell cancer （immunohistochemical staining of tumor cells were positive for CK and Vim, but negative for SMA, HMB-45 and HHF-35, Fig. 1） 10 years after a nephrectomy due to a right renal cancer. At that time, he was treated with photodynamic therapy followed by bio-immunotherapy（interleukine-2 plus lymphokine-activated killer cells）. Follow-up by an abdominal CT scan every 3 months showed significant regression of the left renal carcinoma.
