期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
LUPUS NEPHRITIS COMPLICATED WITH MALIGNANT HYPERTENSION:FROM RENAL VASCULAR PATHOLOGY TO CLINICAL RELEVANCE 被引量:2
1
作者 Jian-ling Tao Hang Li Yu Tang Yu-bing Wen Xue-wang Li 《Chinese Medical Sciences Journal》 CAS CSCD 2008年第2期81-87,共7页
Objective To investigate the clinical and pathological characteristics of lupus nephritis patients complicated with malignant hypertension.Methods We retrospectively studied 19 patients with lupus nephritis complicate... Objective To investigate the clinical and pathological characteristics of lupus nephritis patients complicated with malignant hypertension.Methods We retrospectively studied 19 patients with lupus nephritis complicated with malignant hypertension who underwent renal biopsy between January 2002 and December 2006.Results Of 19 patients,3 were men and 16 were women,with a mean age of 24.4±7.7 years old.All had positive antinuclear antibodies and low serum complement was found in 13 patients.All were anemic and 12 of them were thrombocytopenic.Impaired renal function was found in 17 patients with an average serum creatinine of 184.5±88.9 μmol/L.Severe intrarenal arteriolar lesion was found in all patients.Six patients had lupus vasculopathy,11 patients had renal thrombotic microangiopathy lesion,2 had severe arteriosclerosis.All patients received steroids and immunosuppressive drugs,15 received angiotensin-converting enzyme inhibitor(ACEI)/angiotensin receptor blocker(ARB)with resultant well-controlled blood pressure.Thrombocytopenia and hemolytic anemia resolved remarkably.The renal function improved or recovered in 14 of 17 patients,and 3 developed end-stage renal disease on maintenance dialysis.Conclusions Severe intrarenal vascular lesion complicated with renal nephritis parallels clinical manifestation of malignant hypertension.Renal pathology is the key of treatment strategy emphasizing on the significance of renal vascular involvement and type.On the basis of immunosuppressive drugs and steroids to control systemic lupus activity,timely initiation of ACEI/ARB could be of benefit to blood pressure control and long term renal survival. 展开更多
关键词 lupus nephritis malignant hypertension renal pathology renal vascular involvement thrombotic microangiopathy
下载PDF
经皮腔内肾动脉支架成形术治疗动脉粥样硬化性肾动脉狭窄的疗效分析 被引量:7
2
作者 郭连瑞 谷涌泉 +3 位作者 张建 李建新 俞恒锡 汪忠镐 《中国修复重建外科杂志》 CAS CSCD 北大核心 2010年第9期1037-1040,共4页
目的探讨经皮腔内肾动脉支架成形术(percutaneous transluminal renal artery stenting,PTRAS)治疗动脉粥样硬化性肾动脉狭窄(atherosclerotic renal artery stenosis,ARAS)的疗效。方法回顾分析2002年1月-2008年12月,采用PTRAS治疗69例... 目的探讨经皮腔内肾动脉支架成形术(percutaneous transluminal renal artery stenting,PTRAS)治疗动脉粥样硬化性肾动脉狭窄(atherosclerotic renal artery stenosis,ARAS)的疗效。方法回顾分析2002年1月-2008年12月,采用PTRAS治疗69例ARAS患者的临床资料。男47例,女22例;年龄42~88岁,平均66.2岁。单侧66例,其中1例为单功能肾;双侧3例。肾动脉造影显示肾动脉狭窄程度为70%~99%。合并高血压67例,外周血管病损69例,冠心病34例,糖尿病44例,高血脂症36例。观察患者术后肾功能及血压变化并分析疗效。结果 1例肾动脉狭窄程度为99%的患者因急性夹层导致急性肾动脉闭塞,改行急诊旁路移植术;余68例均成功植入肾动脉支架,成功率为98.6%。68例肾动脉支架成功植入者中,1例术后3个月失访,1例术后6个月死于心肌梗死;余66例获随访,随访时间13~60个月,平均32个月。随访12个月时,血清肌酐水平为(107.8±35.4)μmol/L,与术前(104.1±33.8)μmol/L比较差异无统计学意义(P>0.05);9例肾功能改善(13.6%),48例稳定(72.8%),9例恶化(13.6%),肾功能获益率为86.4%。64例术前高血压患者随访12个月时,收缩压自术前(163±34)mm Hg(1mm Hg=0.133kPa)降至(132±24)mm Hg,舒张压自术前(89±17)mm Hg降至(78±11)mm Hg,差异均有统计学意义(P<0.05);4例高血压治愈(6.3%),52例改善(81.2%),8例失败(12.5%),高血压获益率为87.5%。随访12个月时2例(3.0%)出现再狭窄。结论 PTRAS治疗ARAS的手术成功率高,有助于高血压患者血压控制和稳定肾功能,远期疗效需进一步随访观察。 展开更多
关键词 动脉粥样硬化性动脉狭窄 经皮腔内动脉支架成形术 动脉狭窄 肾血管性高血
原文传递
Explore the direct and/or the synergistic antihypertensive effects of wind-dispelling herbs involving Fangfeng and Baizhi on hypertensive rats with liver-yang hyperactivity based on vasoactive substances
3
作者 Bo Liang Feng-Ying Luo Hui-Ling Liao 《TMR Modern Herbal Medicine》 2018年第1期19-28,共10页
Objective: To explore the direct and/or the enhancing antihypertensive effects of wind-dispelling herbs involvingFangfeng (Saposhnikoviae Radix) and Baizhi (Angelicae dahuricae Radix) using liver-yang hyperactivi... Objective: To explore the direct and/or the enhancing antihypertensive effects of wind-dispelling herbs involvingFangfeng (Saposhnikoviae Radix) and Baizhi (Angelicae dahuricae Radix) using liver-yang hyperactivity renalhypertension rat. Methods: Model rats with hyperactivity of liver-yang hyperactivity were prepared using male SD rats.Once successful, the rats were randomly divided into groups and given medicine by gavage for 4 weeks. Blood wascollected from the abdominal aorta to prepare serum. Serum nitric oxide (NO) concentration was determined bychemical colorimetry. The contents of ET, TXB2 and 6-K-PGF1a were determined by enzyme linked immunosorbentassay (ELISA). Results: Compared with the control model group, the blood pressure, serum ET and TXB2 of rats in thewind dispelling medicine group was not significantly reduced, while those of rats in captopril group, Tianma GoutengDecoction I group (TGD group) decreased significantly (P 〈0.05 for both). Interestingly, the blood pressure, serum ETand TXB2 of rats in the combination group (wind dispelling medicine & TGD) decreased significantly compared withboth wind dispelling medicine group and TGD group. Meanwhile, the levels of serum NO and 6- K-PGF1a in thecombination group was much higher than those in the wind dispelling medicine group or TGD group (P 〈0.05 for both).However, the levels of serum NO and 6- K-PGF1a in the wind dispelling medicine group was not significantly increasedcompared with the model group. Conclusion: There is no direct pressure lowering effects of wind dispelling medicinealone, while wind dispelling medicine could potentiates the antihypertensive effects of Tianma Gouteng Decoction I.Besides, the synergistic effects may be related to decreased ET and TXB2 levels and the increased NO and 6- K-PGF1alevels. 展开更多
关键词 Liver-yang hyperactivity renal hypertension Vasoactive substances Wind dispelling medicine (Fangfeng(Saposhnikoviae Radix) Baizhi (Angelicae dahuricae Radix)) Synergistic antihypertensive mechanism
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部