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基本方加辨证分型治疗慢性肾功能衰竭疗效观察 被引量:9
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作者 余信国 李静 江德乐 《四川中医》 北大核心 2004年第8期40-41,共2页
目的 :通过治疗、观察和随访了解基本方加辨证分型法治疗慢性肾衰的近、远期疗效。方法 :用基本方加辨证分型疗法对慢性肾衰进行 2~ 6年的治疗 ,并对其中 80例进行 2年以上的随访。结果 :80例患者近期病情稳定率为 87 5 % ,2~ 6年病... 目的 :通过治疗、观察和随访了解基本方加辨证分型法治疗慢性肾衰的近、远期疗效。方法 :用基本方加辨证分型疗法对慢性肾衰进行 2~ 6年的治疗 ,并对其中 80例进行 2年以上的随访。结果 :80例患者近期病情稳定率为 87 5 % ,2~ 6年病情稳定率为 81 3%。结论 :基本方加辨证分型疗法治疗CRF患者近、远期疗效较好 ,值得探讨。 展开更多
关键词 辨证分 慢性功能 辨证分 肾衰ⅰ型
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TypeⅠinositol 1, 4, 5-triphosphate receptors increase in kidney of mice with fulminant hepatic failure 被引量:7
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作者 Ying Wen Wei Cui Pei Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第16期2344-2348,共5页
AIM: To delineate the mechanisms of renal vasoconstriction in hepatorenal syndrome (HRS), we investigated the expression of type I inositol 1, 4, 5-triphosphate receptors (IP3R I) of kidney in mice with fulminant... AIM: To delineate the mechanisms of renal vasoconstriction in hepatorenal syndrome (HRS), we investigated the expression of type I inositol 1, 4, 5-triphosphate receptors (IP3R I) of kidney in mice with fulminant hepatic failure (FHF). METHODS: FHF was induced by lipopolysaccharide (LPS) in D-galactosamine (GAIN) sensitized BALB/c mice. There were 20 mice in normal saline (NS)-treated group, 20 mice in LPS-treated group, 20 mice in GaIN- treated group, and 60 mice in GalN/LPS-treated group (FHF group). Liver and kidney tissues were obtained at 2, 6, and 9 h after administration. The liver and kidney specimens were stained with hematoxylin-eosin for studying morphological changes under light microscope. The expression of IP3R I in kidney tissue was tested by immunohistochemistry, Western blot and reverse transcription (RT)-PCR. RESULTS: Kidney tissues were morphologically normal at all time points in all groups. IP3R I proteins were found localized in the plasma region of glomerular mesangial cells (GMC) and vascular smooth muscle cells (VSMC) in kidney by immunohistochemical staining. In kidney of mice with FHF at 6 h and 9 h IP3R I staining was upregulated. Results from Western blot demonstrated consistent and significant increment of IP3R I expression in mice with FHF at 6 h and 9 h (t = 3.16, P 〈 0.05; t = 5.43, P 〈 0.01). Furthermore, we evaluated IP3R I mRNA expression by RT-PCR and observed marked upregulation of IP3R I mRNA in FHF samples at 2 h, 6 h and 9 h compared to controls (t = 2.97, P 〈 0.05; t = 4.42, P 〈 0.01; t = 3.81, P 〈 0.01). CONCLUSION: The expression of IP3R I protein increased in GMC and renal VSMC of mice with FHF, possibly caused by up-regulation of IP3R I mRNA. 展开更多
关键词 Hepatorenal syndrome Fulminant hepatic failure Type inositol 1 4 5-trisphophate receptors Glomerular mesangial cells Vascular smooth muscle cells
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