Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud....Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.展开更多
The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating...The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating effect on cell growth in gastrointestinal malignancies such as pancreatic carcinomas. The article by Zhou et al is all the more important because it highlights the rapidly increasing role of triplodide in the management of systemic malignancies. For instance, triptolide acts on the PI3K/Akt/NF-κB pathway, thereby enhancing apoptosis secondary to the administration of bortezomib in multiple myeloma cells. Similar synergisms are seen when triptolide is administered along with 5-fluoruracil for the management of colonic carcinomas. Similarly, triptolide causes down-regulation of the Bcl-2 gene, resulting in control of cell growth in tumors, such as glioblastoma multiformes.展开更多
Objective: To study the anticancer effect of Chinese compound recipe FuFangTengLiGen (FFTLG) against trans- plantation tumor of PG cell and preliminarily explore the connection with connexin43 (Cx43) and epithelial ca...Objective: To study the anticancer effect of Chinese compound recipe FuFangTengLiGen (FFTLG) against trans- plantation tumor of PG cell and preliminarily explore the connection with connexin43 (Cx43) and epithelial cadherin (E-cad). Methods: Model rats of transplantation tumor of human large cell cancer PG were established. The low, medium and high dose groups of FFTLG, the blank control group were set up. After 21 days medication of FFTLG through gastrogavage, the antitumor effect of each group was compared. The gene expressions of Cx43 and E-cad in each group were quantitatively detected and compared by the application of immunohistochemistry technique. Results: FFTLG could significantly inhibit the growth of transplantation tumor. FFTLG could obviously up-regulate the expressions of Cx43 and E-cad, which in the low/medium and high dose groups were separately higher than that in the blank group. Conclusion: FFTLG has definite antitumor effect against human large cell cancer and can obviously up-regulate the expressions of Cx43 and E-cad, which may be correlated with its effect of anti-tumor.展开更多
Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine deriv...Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl sub- stituent have been found to exhibit much more potent TNF-a inhibitory activity than natural sinomenine and other derivatives.展开更多
文摘Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.
文摘The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating effect on cell growth in gastrointestinal malignancies such as pancreatic carcinomas. The article by Zhou et al is all the more important because it highlights the rapidly increasing role of triplodide in the management of systemic malignancies. For instance, triptolide acts on the PI3K/Akt/NF-κB pathway, thereby enhancing apoptosis secondary to the administration of bortezomib in multiple myeloma cells. Similar synergisms are seen when triptolide is administered along with 5-fluoruracil for the management of colonic carcinomas. Similarly, triptolide causes down-regulation of the Bcl-2 gene, resulting in control of cell growth in tumors, such as glioblastoma multiformes.
文摘Objective: To study the anticancer effect of Chinese compound recipe FuFangTengLiGen (FFTLG) against trans- plantation tumor of PG cell and preliminarily explore the connection with connexin43 (Cx43) and epithelial cadherin (E-cad). Methods: Model rats of transplantation tumor of human large cell cancer PG were established. The low, medium and high dose groups of FFTLG, the blank control group were set up. After 21 days medication of FFTLG through gastrogavage, the antitumor effect of each group was compared. The gene expressions of Cx43 and E-cad in each group were quantitatively detected and compared by the application of immunohistochemistry technique. Results: FFTLG could significantly inhibit the growth of transplantation tumor. FFTLG could obviously up-regulate the expressions of Cx43 and E-cad, which in the low/medium and high dose groups were separately higher than that in the blank group. Conclusion: FFTLG has definite antitumor effect against human large cell cancer and can obviously up-regulate the expressions of Cx43 and E-cad, which may be correlated with its effect of anti-tumor.
基金supported by the National Basic Research Program of China(973 Program,2010CB833200)National Natural Science Foundation of China(90713044,21032002)+1 种基金SHMCST (08431903000)the Fundamental Research Funds for the Central Universities(1082020502)
文摘Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl sub- stituent have been found to exhibit much more potent TNF-a inhibitory activity than natural sinomenine and other derivatives.
