目的探讨精神、心理因素与功能性消化不良(FD)的关系及抗抑郁药联合胃动力药对其疗效。方法采用随机对照方法,以抗抑郁药联合促胃动力药的治疗组30例,以促胃动力药为治疗的对照组22例,进行汉密尔顿抑郁量表(H AM D)、汉密尔顿焦虑量表(H...目的探讨精神、心理因素与功能性消化不良(FD)的关系及抗抑郁药联合胃动力药对其疗效。方法采用随机对照方法,以抗抑郁药联合促胃动力药的治疗组30例,以促胃动力药为治疗的对照组22例,进行汉密尔顿抑郁量表(H AM D)、汉密尔顿焦虑量表(H AM A)和消化症状评分。结果治疗组较对照组有明显改善(P<0.05)。结论抗抑郁药对功能性消化不良有确切疗效,与促胃动力联合使用有协同作用。展开更多
To investigate the effect of chronic gastric electrical stimulation (GES) on the daily use of prokinetics and antiem- etics, hospitalizations, total symptom score (TSS), SF- 36 status for health- related quality of li...To investigate the effect of chronic gastric electrical stimulation (GES) on the daily use of prokinetics and antiem- etics, hospitalizations, total symptom score (TSS), SF- 36 status for health- related quality of life (HQOL), and gastric emptying of a solid meal, we evaluated 37 gastroparetic patients preoperatively and 1 year after undergoing GES implant. Prokinetic and antiemetic use was significantly reduced. Of 27 patients on at least one prokinetic at baseline, 8 were off at 1 year. Twenty- six patients requiring antiemetics before surgery decreased to 17. Mean TSS was significantly reduced and the reduction for patients off medications was significantly better than for patients still on medications. Overall SF- 36 scores for HQOL were significantly improved, and patients off antiemetics had a significantly higher HQOL score than for patients on antiemetics at 1 year. Hospitalizations decreased from 50 ± 10 days for the year prior to GES therapy to 14± 3 days (P < 0.05). However, gastric emptying was not significantly improved. Conclusions are as follows. (1) Chronic GES significantly reduced the use of prokinetic/antiemetic medications and the need for hospitalization in gastropraretic patients, whose clinical and quality of life outcomes also significantly improved (2) These data provide evidence of the positive economic impact of this new therapy on long- term clinical outcomes in gastroparetic patients not responding to standard medical therapy.展开更多
文摘目的探讨精神、心理因素与功能性消化不良(FD)的关系及抗抑郁药联合胃动力药对其疗效。方法采用随机对照方法,以抗抑郁药联合促胃动力药的治疗组30例,以促胃动力药为治疗的对照组22例,进行汉密尔顿抑郁量表(H AM D)、汉密尔顿焦虑量表(H AM A)和消化症状评分。结果治疗组较对照组有明显改善(P<0.05)。结论抗抑郁药对功能性消化不良有确切疗效,与促胃动力联合使用有协同作用。
文摘To investigate the effect of chronic gastric electrical stimulation (GES) on the daily use of prokinetics and antiem- etics, hospitalizations, total symptom score (TSS), SF- 36 status for health- related quality of life (HQOL), and gastric emptying of a solid meal, we evaluated 37 gastroparetic patients preoperatively and 1 year after undergoing GES implant. Prokinetic and antiemetic use was significantly reduced. Of 27 patients on at least one prokinetic at baseline, 8 were off at 1 year. Twenty- six patients requiring antiemetics before surgery decreased to 17. Mean TSS was significantly reduced and the reduction for patients off medications was significantly better than for patients still on medications. Overall SF- 36 scores for HQOL were significantly improved, and patients off antiemetics had a significantly higher HQOL score than for patients on antiemetics at 1 year. Hospitalizations decreased from 50 ± 10 days for the year prior to GES therapy to 14± 3 days (P < 0.05). However, gastric emptying was not significantly improved. Conclusions are as follows. (1) Chronic GES significantly reduced the use of prokinetic/antiemetic medications and the need for hospitalization in gastropraretic patients, whose clinical and quality of life outcomes also significantly improved (2) These data provide evidence of the positive economic impact of this new therapy on long- term clinical outcomes in gastroparetic patients not responding to standard medical therapy.
