以往认为肥大细胞(Mast cell,MC)是介导速发型超敏反应的关键细胞,主要在机体过敏性反应中发挥作用。然而,近年来对 MC 的分子生物学其在皮肤创伤愈合中的作用进行了大量的研究,认为它参与了创伤愈合的出血与凝血、炎症渗出、血管和肉...以往认为肥大细胞(Mast cell,MC)是介导速发型超敏反应的关键细胞,主要在机体过敏性反应中发挥作用。然而,近年来对 MC 的分子生物学其在皮肤创伤愈合中的作用进行了大量的研究,认为它参与了创伤愈合的出血与凝血、炎症渗出、血管和肉芽组织的形成、再上皮化、纤维化和瘢痕改建过程的各个方面,对体内环境稳定和修复具有一定作用,在病理情况下也造成组织损伤和病变。本文就 MC 上述方面的进展作一综述。MC 在种族遗传上是古老的细胞,广泛分布于哺乳动物各器官,但主要分布于机体与环境的交界处。展开更多
Angiotensin Ⅱ has been reported to have an important role in the fibrotic response to tissue injuries:it stimulates the proliferation of fibroblasts via activation of angiotensin Ⅱ（AT1) receptor.In the present stud...Angiotensin Ⅱ has been reported to have an important role in the fibrotic response to tissue injuries:it stimulates the proliferation of fibroblasts via activation of angiotensin Ⅱ（AT1) receptor.In the present study,whether Ang Ⅱ forming enzymes,angiotensin converting enzyme(ACE) and chymase,which were activated in pulmonary fibrosis induced by paraquat(PQ) were examined in hamsters.PQ was administered subcutaneously once a week at a dose of 6mg·kg^-1 for four weeks and the 18mg·kg^-1 for six weeks.Interstitial and superficial pulmonary fibrosis were found five weeks after administration.Chymase activity was significantly increased in the PQ group when compared with saline group.ACE activity,on the other hand,was not significantly different.There data support the possible role of angiotensin Ⅱ,via activation of chymase,to the PQ-induced pulmonary fibrosis.展开更多
文摘以往认为肥大细胞(Mast cell,MC)是介导速发型超敏反应的关键细胞,主要在机体过敏性反应中发挥作用。然而,近年来对 MC 的分子生物学其在皮肤创伤愈合中的作用进行了大量的研究,认为它参与了创伤愈合的出血与凝血、炎症渗出、血管和肉芽组织的形成、再上皮化、纤维化和瘢痕改建过程的各个方面,对体内环境稳定和修复具有一定作用,在病理情况下也造成组织损伤和病变。本文就 MC 上述方面的进展作一综述。MC 在种族遗传上是古老的细胞,广泛分布于哺乳动物各器官,但主要分布于机体与环境的交界处。
文摘Angiotensin Ⅱ has been reported to have an important role in the fibrotic response to tissue injuries:it stimulates the proliferation of fibroblasts via activation of angiotensin Ⅱ（AT1) receptor.In the present study,whether Ang Ⅱ forming enzymes,angiotensin converting enzyme(ACE) and chymase,which were activated in pulmonary fibrosis induced by paraquat(PQ) were examined in hamsters.PQ was administered subcutaneously once a week at a dose of 6mg·kg^-1 for four weeks and the 18mg·kg^-1 for six weeks.Interstitial and superficial pulmonary fibrosis were found five weeks after administration.Chymase activity was significantly increased in the PQ group when compared with saline group.ACE activity,on the other hand,was not significantly different.There data support the possible role of angiotensin Ⅱ,via activation of chymase,to the PQ-induced pulmonary fibrosis.
