胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基...胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基于网络药理学方法探讨益胃抗癌汤治疗胃癌前病变的分子机制,获得益胃抗癌汤1889个活性成分和499个潜在治疗靶点,通过GeneCards得到胃癌前病变1612个相关靶点,交集靶点168个,从PPI核心网络筛选出71个关键靶点,GO和KEGG分析相关靶基因,参与了4870个生物学反应过程、447个细胞功能、329个细胞组分以及345个相关信号通路,通过分子对接,所有核心靶基因与核心成分均具有较好的结合活性,其中对接分数较高的是小檗碱、非洲防己碱和氢化小檗碱。为临床应用和进一步的实验验证提供参考。展开更多
Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug tar...Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug targets and interacting pathways of SJZ decoction in treating GPL.The compounds and predicted targets of SJZ decoction were screened from TCMSP,and the disease targets were obtained from GeneCards.The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology(GO)enrichment,Kyoto encyclopedia of genes and genomes pathway enrichment analyses.Results:The results show that 111 compounds and 90 targets were obtained in this work.These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways.Active compounds,targets,and pathways were used to construct a compound-target network,a target-pathways network,and an integrated GPL pathway.These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation,cell apoptosis process,and cell proliferation.Conclusions:This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction,which facilitate the modernization of herbal medicine for complex diseases in the future.展开更多
OBJECTIVE:To investigate the clinical effects of modified Dachengqi Tang(DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.METHODS:Sixty postoperative esophageal cancer patients...OBJECTIVE:To investigate the clinical effects of modified Dachengqi Tang(DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.METHODS:Sixty postoperative esophageal cancer patients were enrolled and randomly assigned to the modified treatment group or the control group(30 patients in each group).Patients in the treatment group were given DCQT made from decocted herbs and administered via nasojejunal tube at a dosage of 150 mL.Gastrointestinal motility was assessed by recording time for recovery of bowel sounds,flatus,defecation,and the total amount of gastric drainage during the first three postoperative days.Plasma motilin(MTL) and vasoactive intestinal peptide(VIP) were measured one hour before and three days after surgery.RESULTS:Compared with the control group,the times to first bowel sound,flatus,and defecation were significantly shorter and there was less gastric drainage in the treatment group(P < 0.01,P < 0.01,P < 0.01,and P < 0.05,respectively).In the treatment group,postoperative plasma MTL was significantly higher(P < 0.01) and VIP was significantly lower than those in the control group(P < 0.05).There was no difference found in either MTL or VIP from before to after operation in the treatment group(P > 0.05).MTL was significantly lower and VIP was higher postoperatively in the control group,compared to before surgery(P < 0.01).CONCLUSION:Modified DCQT effectively improved decreased gastrointestinal motility in postoperative esophageal cancer patients by increasing MTL and reducing VIP.展开更多
文摘胃癌发病率和病死率逐年上升,胃癌前病变(precancerous lesions of gastric cancer,PLGC)是正常胃黏膜转化成胃癌的重要过程。益胃抗癌汤为王新杰教授自拟方,通过多年临床运用发现其在改善胃黏膜功能,延缓胃癌进程方面疗效显著,文章基于网络药理学方法探讨益胃抗癌汤治疗胃癌前病变的分子机制,获得益胃抗癌汤1889个活性成分和499个潜在治疗靶点,通过GeneCards得到胃癌前病变1612个相关靶点,交集靶点168个,从PPI核心网络筛选出71个关键靶点,GO和KEGG分析相关靶基因,参与了4870个生物学反应过程、447个细胞功能、329个细胞组分以及345个相关信号通路,通过分子对接,所有核心靶基因与核心成分均具有较好的结合活性,其中对接分数较高的是小檗碱、非洲防己碱和氢化小檗碱。为临床应用和进一步的实验验证提供参考。
文摘Objective:To find out the potential mechanisms of Si-Jun-Zi(SJZ)decoction in the treatment of gastric precancerous lesions(GPL).Methods:A network pharmacology approach was used to analyze the active compounds,drug targets and interacting pathways of SJZ decoction in treating GPL.The compounds and predicted targets of SJZ decoction were screened from TCMSP,and the disease targets were obtained from GeneCards.The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology(GO)enrichment,Kyoto encyclopedia of genes and genomes pathway enrichment analyses.Results:The results show that 111 compounds and 90 targets were obtained in this work.These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways.Active compounds,targets,and pathways were used to construct a compound-target network,a target-pathways network,and an integrated GPL pathway.These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation,cell apoptosis process,and cell proliferation.Conclusions:This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction,which facilitate the modernization of herbal medicine for complex diseases in the future.
基金the Administration of Shandong Provincial Traditional Chinese Medicine,China,No.2009-166
文摘OBJECTIVE:To investigate the clinical effects of modified Dachengqi Tang(DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.METHODS:Sixty postoperative esophageal cancer patients were enrolled and randomly assigned to the modified treatment group or the control group(30 patients in each group).Patients in the treatment group were given DCQT made from decocted herbs and administered via nasojejunal tube at a dosage of 150 mL.Gastrointestinal motility was assessed by recording time for recovery of bowel sounds,flatus,defecation,and the total amount of gastric drainage during the first three postoperative days.Plasma motilin(MTL) and vasoactive intestinal peptide(VIP) were measured one hour before and three days after surgery.RESULTS:Compared with the control group,the times to first bowel sound,flatus,and defecation were significantly shorter and there was less gastric drainage in the treatment group(P < 0.01,P < 0.01,P < 0.01,and P < 0.05,respectively).In the treatment group,postoperative plasma MTL was significantly higher(P < 0.01) and VIP was significantly lower than those in the control group(P < 0.05).There was no difference found in either MTL or VIP from before to after operation in the treatment group(P > 0.05).MTL was significantly lower and VIP was higher postoperatively in the control group,compared to before surgery(P < 0.01).CONCLUSION:Modified DCQT effectively improved decreased gastrointestinal motility in postoperative esophageal cancer patients by increasing MTL and reducing VIP.
