期刊文献+

二次检索

题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到13篇文章
< 1 >
每页显示 20 50 100
胃镜下病理活检和外科手术病理在胃癌评估中的应用分析
1
作者 申小雄 《中国社区医师》 2022年第16期87-89,共3页
目的:分析胃癌患者采用胃镜下病理活检和外科手术病理在胃癌评估中的临床价值。方法:选取2019年2月-2021年2月广西壮族自治区人民医院收治的胃癌患者共50例。分析胃镜下病理活检和外科手术病理在胃癌评估中的价值。结果:胃镜下病理活检... 目的:分析胃癌患者采用胃镜下病理活检和外科手术病理在胃癌评估中的临床价值。方法:选取2019年2月-2021年2月广西壮族自治区人民医院收治的胃癌患者共50例。分析胃镜下病理活检和外科手术病理在胃癌评估中的价值。结果:胃镜下病理活检和外科手术病理比较,差异无统计学意义(P>0.05)。外科手术病理印戒细胞癌、黏液腺癌检出率高于胃镜下病理活检,差异有统计学意义(P<0.05);两组管状腺癌和乳头状腺癌的检出率比较,差异无统计学意义(P>0.05)。两组诊断方法Ⅰ型诊断结果比较,差异无统计学意义(P>0.05);Ⅱ型、Ⅲ型、Ⅳ型胃镜活检诊断较低,差异有统计学意义(P<0.05)。外科手术病理分化不良型例数少于胃镜下病理活检,差异有统计学意义(P<0.05);外科手术病理分化型例数高于胃镜下病理活检,差异有统计学意义(P<0.05)。结论:胃镜下病理活检可作为术前诊断的良好手段,但对胃癌的全面评估,仍要以外科手术病理结果为依据。 展开更多
关键词 胃镜下病理活检 外科手术病理 胃癌评估 分化
下载PDF
OLGA及OLGIM分期系统对1790例 慢性萎缩性胃炎患者胃癌风险的评估价值 被引量:17
2
作者 吴水清 黄建成 +2 位作者 李达周 王雯 陆晶 《陕西医学杂志》 CAS 2021年第6期756-758,共3页
目的:探讨可操作的与胃癌风险联系的萎缩评估(OLGA)和可操作的与胃癌风险联系的肠化生评估(OLGIM)系统对慢性萎缩性胃炎(CAG)癌变风险的评估价值。方法:1790例CAG患者为研究对象,记录基本资料以及胃镜、病理、幽门螺杆菌(HP)检查结果,分... 目的:探讨可操作的与胃癌风险联系的萎缩评估(OLGA)和可操作的与胃癌风险联系的肠化生评估(OLGIM)系统对慢性萎缩性胃炎(CAG)癌变风险的评估价值。方法:1790例CAG患者为研究对象,记录基本资料以及胃镜、病理、幽门螺杆菌(HP)检查结果,分析OLGA/OLGIM分期与胃黏膜病变的相关性,比较不同OLGA/OLGIM分期患者HP感染情况。结果:1790例CAG中,病理表现为萎缩908例(50.73%),肠化生1384例(77.32%),上皮内瘤变(含癌变)185例(10.34%);OLGA分期中,0期、Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期分别有882例、687例、170例、44例和7例;OLGIM分期中,0期、Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期分别有406例、1092例、221例、53例和18例。OLGA及OLGIM分期与胃黏膜病变均呈正相关(r s=0.096、0.138,均P<0.05)。OLGA及OLGIM各分期HP感染率比较总体差异均具有统计学意义(均P<0.05)。结论:OLGA及OLGIM分期系统对胃癌风险评估具有一定临床价值。 展开更多
关键词 可操作的与胃癌风险联系的萎缩评估 可操作的与胃癌风险联系的肠化生评估 慢性萎缩性胃炎 上皮内瘤变 幽门螺杆菌
下载PDF
基于胃癌高危因素及血清学胃功能指标在胃癌筛查中的应用 被引量:1
3
作者 向桢 安运锋 《右江医学》 2023年第1期24-30,共7页
目的探讨血清学胃功能指标及胃癌高危因素在胃癌筛查中的应用,为胃癌的早期筛查提供参考。方法以2018—2019年在桂林某医院健康体检中心体检人群为研究对象,针对高危人群进行因素筛查。对高危人群进行血清指标检测[包括血清胃蛋白酶原(... 目的探讨血清学胃功能指标及胃癌高危因素在胃癌筛查中的应用,为胃癌的早期筛查提供参考。方法以2018—2019年在桂林某医院健康体检中心体检人群为研究对象,针对高危人群进行因素筛查。对高危人群进行血清指标检测[包括血清胃蛋白酶原(PG)Ⅰ和Ⅱ、胃泌素17(G-17)、PGⅠ/PGⅡ比值(PGR)],检测抗体(Hp-IgG)感染情况。通过调查问卷调查研究对象性别、年龄、体重指数(BMI)、饮食、生活习惯等资料,经胃镜及病理诊断确诊为胃癌,以多因素logistic回归分析模型确定与胃癌发生相关的危险因素,通过受试者工作特征曲线(ROC)验证血清指标对胃癌的诊断效能。针对存在胃癌高危因素受试者进行健康管理,评价健康管理患者效果。结果经问卷调查法筛选出胃癌高危人群2654人,胃镜检查及病理诊断确诊胃癌34人。胃癌患者年龄、胃癌家族史、胃癌前疾病、不良饮食喜好、不良生活习惯、Hp-IgG阳性占比和血清G-17水平高于非胃癌受试者,PGR值低于非胃癌受试者,差异有统计学意义(P<0.05),且经logistic回归分析显示上述因素均为影响胃癌发生的独立危险因素(P<0.001)。ROC结果显示PGR、Hp-IgG、G-17诊断胃癌的AUC分别为0.794、0.789和0.855,三者联合检测诊断胃癌的AUC为0.942,联合检测的AUC大于单独检测(P<0.05)。结论年龄、胃癌家族史、Hp-IgG阳性、血清G-17、PGR等均为影响胃癌发生的独立危险因素,且血清指标Hp-IgG、血清G-17、PGR检测可作为癌前病变高危人群和胃癌的血清学筛查指标。 展开更多
关键词 幽门螺杆菌 胃癌风险评估 健康管理
下载PDF
新型胃癌筛查评分系统和OLGA分级在慢性萎缩性胃炎癌变风险分层中的一致性评价 被引量:4
4
作者 石振旺 方东 +4 位作者 鲍德明 王黎明 许勤 赵敏 陈正徐 《中国老年学杂志》 CAS 北大核心 2023年第15期3649-3652,共4页
目的评价新型胃癌评分系统和可操作的与胃癌风险联系的胃炎评估(OLGA)分级对慢性萎缩性胃炎(CAG)癌变风险分层的一致性,分析其影响因素。方法纳入2020年1月至2021年2月安徽医科大学附属合肥医院消化内科就诊的CAG患者168例,收集人口学资... 目的评价新型胃癌评分系统和可操作的与胃癌风险联系的胃炎评估(OLGA)分级对慢性萎缩性胃炎(CAG)癌变风险分层的一致性,分析其影响因素。方法纳入2020年1月至2021年2月安徽医科大学附属合肥医院消化内科就诊的CAG患者168例,收集人口学资料,采集血清样本检测胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素(G)-17、幽门螺杆菌(Hp)抗体,计算PGⅠ、PGⅡ比值(PGR),完成新型胃癌筛查评分系统评分;根据内镜和病理结果,由萎缩范围和程度进行OLGA分级判定。采用Kappa相关分析评价新型胃癌评分系统和OLGA分级的一致性,单因素和多因素Logistic回归分析影响两种方法一致性的相关因素。结果新型胃癌筛选系统平均评分(9.54±2.63)分,其中低危125例(74.40%)、中高危43例(25.59%);OLGA分级低危(0~Ⅱ级)137例(81.55%),高危(Ⅲ~Ⅳ级)31例(18.45%),Kappa相关分析结果显示两种方法呈中度相关(P=0.000)。两种分层方法同时为“低危”或“高危”的患者146例,吻合率86.90%,设为一致组,危险分层存在差异的患者22例(13.09%),设为非一致组。单因素分析结果显示,两组一级亲属胃癌史、Hp血清抗体分型、木村-竹本分类及高盐饮食存在显著差异(P<0.05),多因素Logistic回归分析示不同抗体分型Hp感染是影响危险分层差异的相关因素(P<0.05)。结论新型胃癌筛选评分系统对评估CAG患者的癌变风险有重要参考价值,具有无创、简便、可重复的优点,但是在临床应用时可能需考虑Hp抗体分型对风险分层的影响。 展开更多
关键词 胃癌筛查 可操作的与胃癌风险联系的胃炎评估(OLGA)分级 慢性萎缩性胃炎 幽门螺旋杆菌
下载PDF
窄带成像放大内镜分级系统在慢性萎缩性胃炎实时诊断及危险分层中的价值研究
5
作者 李倩 郭春梅 +9 位作者 董凤晓 王亚丹 孟明明 刘揆亮 宿慧 余春开 王婧玮 朱丽存 吴静 刘红 《胃肠病学和肝病学杂志》 CAS 2024年第6期698-702,共5页
目的探讨窄带成像放大内镜(narrow band imaging magnification endoscopy,NBI-ME)分级系统在慢性萎缩性胃炎(chronic atrophic gastritis,CAG)实时诊断及危险分层中的价值。方法收集40岁以上接受NBI-ME检查患者的内镜和病理资料,评估NB... 目的探讨窄带成像放大内镜(narrow band imaging magnification endoscopy,NBI-ME)分级系统在慢性萎缩性胃炎(chronic atrophic gastritis,CAG)实时诊断及危险分层中的价值。方法收集40岁以上接受NBI-ME检查患者的内镜和病理资料,评估NBI-ME分级系统和组织病理学金标准—OLGA/OLGIM(operative link for gastritis assessment/operative link for gastric intestinal metaplasia assessment)分期系统的相关性及一致性。结果共纳入63例患者,男41例,女22例,胃窦和胃体部的NBI-ME评分和组织学评分的一致性均为73.0%,总体一致性显著(Kappa=0.695,P<0.05;加权Kappa=0.907,P<0.05),其中胃窦的一致性良好(Kappa=0.604,P<0.05),胃体的一致性中等(Kappa=0.487,P<0.05);Cochran-Mantel-Haenszel分析表明,高危NBI-ME分级(Ⅱ~Ⅳ级)的患者诊断为高危OLGA/OLGIM分期的可能性更高(P<0.0001),NBI-ME分级诊断高危CAG/GIM的敏感性为81.8%(95%CI:59.7%~94.8%),特异性为95.1%(95%CI:83.5%~99.4%)。结论NBI-ME评分与组织病理学评分具有较高一致性,它是一种简便、经济并实时诊断CAG及识别胃癌高危人群的检查及随访方式。 展开更多
关键词 窄带成像放大内镜 慢性萎缩性胃炎 实时诊断 危险分层 可操作的与胃癌风险联系的肠化生评估
下载PDF
不同OLGIM分期胃炎患者PGⅠ、PGR水平变化及HP感染状况分析 被引量:5
6
作者 袁惠 王溪 《海南医学》 CAS 2023年第1期26-29,共4页
目的 研究不同可操作的与胃癌风险联系的肠化生评估(OLGIM)分期胃炎患者胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原比值(PGR)水平及幽门螺杆菌(HP)感染状况。方法 回顾性选取2019年1月至2021年1月西安高新医院消化内科收治的120例胃炎患者纳入观察... 目的 研究不同可操作的与胃癌风险联系的肠化生评估(OLGIM)分期胃炎患者胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原比值(PGR)水平及幽门螺杆菌(HP)感染状况。方法 回顾性选取2019年1月至2021年1月西安高新医院消化内科收治的120例胃炎患者纳入观察组,同期选择在我院体检的110例健康人群作为对照组。比较两组受检者的血清PGI水平、PGR及HP感染状况,并比较不同OLGIM分期胃炎患者的血清PGⅠ水平、PGR及HP感染状况,采用Pearson相关性分析法分析血清PGI水平、PGR及HP感染阳性率与OLGIM分期的相关性。结果 观察组患者的血清PGⅠ水平、PGR分别为(74.89±3.71) ng/mL、5.16±1.01,明显低于对照组的(95.40±5.85) ng/m L、7.43±1.60,Hp感染阳性率为66.67%,明显高于对照组的13.64%,差异均有统计学意义(P<0.05);四组OLGIM分期患者的血清PGⅠ水平、PGR水平均逐渐降低,HP感染阳性率逐渐升高,其中Ⅳ期组胃炎患者的血清PGⅠ水平、PGR水平均明显低于Ⅲ期组、Ⅱ期组和Ⅰ期组,HP感染阳性率明显高于Ⅲ期组、Ⅱ期组和Ⅰ期组,Ⅲ期组胃炎患者的血清PGⅠ水平、PGR水平均明显低于Ⅱ期组和Ⅰ期组,HP感染阳性率明显高于Ⅱ期组和Ⅰ期组,Ⅱ期组胃炎患者的血清PGⅠ水平、PGR水平均明显低于Ⅰ期组,HP感染阳性率明显高于Ⅰ期组,组间比较差异均有统计学意义(P<0.05);经Pearson相关分析结果显示,PGⅠ、PGR与OLGIM分期均呈负相关(r=-0.607、-0.528,P<0.05),HP感染阳性率与OLGIM分期呈正相关(r=0.720,P<0.05)。结论 血清PGⅠ水平、PGR在Ⅳ期胃炎患者中的表达水平明显降低,HP感染阳性率有明显升高,血清PGⅠ水平、PGR及HP感染状况与OLGIM分期进展程度有明显相关性。 展开更多
关键词 胃炎 可操作的与胃癌风险联系的肠化生评估 胃蛋白酶原Ⅰ 胃蛋白酶原比值 幽门螺杆菌 感染
下载PDF
Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance 被引量:18
7
作者 Kamran Ghaffarzadehgan Mostafa Jafarzadeh +6 位作者 Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第41期6376-6381,共6页
AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences betwee... AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. 展开更多
关键词 Gastric cancer Cluster of differentiation 44 Survival rateImmunohistochemistry Cell adhesion molecules
下载PDF
Does N ratio affect survival in D1 and D2 lymph node dissection for gastric cancer? 被引量:3
8
作者 Ibrahim Sakcak Baris Dogu Yildiz +4 位作者 Fatih Mehmet Avsar Saadet Akturan Kemal Kilic Erdal Cosgun Enver O Hamamci 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第35期4007-4012,共6页
AIM:To identify whether there could have been changes in survival if lymph node ratio (N ratio) had been used.METHODS:We assessed 334 gastric adenocarcinoma cases retrospectively between 2001 and 2009.Two hundred and ... AIM:To identify whether there could have been changes in survival if lymph node ratio (N ratio) had been used.METHODS:We assessed 334 gastric adenocarcinoma cases retrospectively between 2001 and 2009.Two hundred and sixteen patients out of 334 were included in the study.Patients were grouped according to disection1 (D1) or dissection 2 (D2) dissection.We compared the estimated survival and actual survival determined by Pathologic nodes (pN) class and N ratio,and SPSS 15.0 software was used for statistical analysis.RESULTS:Ninety-six (44.4%) patients underwent D1 dissection and 120 (55.6%) had D2 dissection.When groups were evaluated,23 (24.0%) patients in D1 and 21 (17.5%) in D2 had stage migration (P=0.001).When both D1 and D2 groups were evaluated for number of pathological lymph nodes,despite the fact that there was no difference in N ratio between D1 and D2 groups,a statistically significant difference was found between them with regard to pN1 and pN2 groups (P=0.047,P=0.044 respectively).In D1,pN0 had the longest survival while pN3 had the shortest.In D2,pN0 had the longest survival whereas pN3 had the shortest survival.CONCLUSION:N ratio is an accurate staging system for defining prognosis and treatment plan,thus decreasing methodological errors in gastric cancer staging. 展开更多
关键词 Gastric cancer Lymph node dissection Node ratio Tumor nodule metastasis
下载PDF
Quantitative assessment model for gastric cancer screening 被引量:1
9
作者 KtmChea Wei-PingYu LiangSong Yi-MinZhu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第5期641-644,共4页
AIM: To set up a mathematic model for gastric cancer screening and to evaluate its function in mass screening for gastric cancer.METHODS: A case control study was carried on in 66patients and 198 normal people, then t... AIM: To set up a mathematic model for gastric cancer screening and to evaluate its function in mass screening for gastric cancer.METHODS: A case control study was carried on in 66patients and 198 normal people, then the risk and protective factors of gastric cancer were determined, including heavy manual work, foods such as small yellow-fin tuna, dried small shrimps, squills, crabs, mothers suffering from gastric diseases, spouse alive, use of refrigerators and hot food,etc. According to some principles and methods of probability and fuzzy mathematics, a quantitative assessment model was established as follows: first, we selected some factors significant in statistics, and calculated weight coefficient for each one by two different methods; second, population space was divided into gastric cancer fuzzy subset and non gastric cancer fuzzy subset, then a mathematic model for each subset was established, we got a mathematic expression of attribute degree (AD).RESULTS: Based on the data of 63 patients and 693 normal people, AD of each subject was calculated. Considering the sensitivity and specificity, the thresholds of AD values calculated were configured with 0.20 and 0.17, respectively.According to these thresholds, the sensitivity and specificity of the quantitative model were about 69% and 63%.Moreover, statistical test showed that the identification outcomes of these two different calculation methods were identical (P>0.05).CONCLUSION: The validity of this method is satisfactory.It is convenient, feasible, economic and can be used to determine individual and population risks of gastric cancer. 展开更多
关键词 Gastric cancer Mass screening Quantitative assessment model
下载PDF
Improved quality of life in patients with gastric cancer after esophagogastrostomy reconstruction 被引量:57
10
作者 Hao Zhang Zhe Sun Hui-Mian Xu Ji-Xian Shan Shu-Bao Wang Jun-Qing Chen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第25期3183-3190,共8页
AIM:To compare postoperative quality of life (QOL) in patients with gastric cancer treated by esophagogastrostomy reconstruction after proximal gastrectomy.METHODS: QOL assessments that included functional outcomes (a... AIM:To compare postoperative quality of life (QOL) in patients with gastric cancer treated by esophagogastrostomy reconstruction after proximal gastrectomy.METHODS: QOL assessments that included functional outcomes (a 24-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) were performed in 149 patients with gastric cancer in the upper third of the stomach, who had received proximal gastrectomy with additional esophagogastrostomy.RESULTS: Fifty-four patients underwent reconstruction by esophagogastric anterior wall end-to-side anastomosis combined with pyloroplasty (EA group); 45 patients had reconstruction by esophagogastric posterior wall end-to-side anastomosis (EP group); and 50 patients had reconstruction by esophagogastric end-to-end anastomosis (EE group). The EA group showed the best postoperative QOL, such as recovery of body weight, less discomfort after meals, and less heart burn or belching at 6 and 24 mo postoperatively. However, the survival rates, surgical results and Spitzer QOL index were similar among the three groups.CONCLUSION: Postoperative QOL was better in the EA than EP or EE group. To improve QOL after proximal gastrectomy for upper third gastric cancer, the EA procedure using a stapler is safe and feasible for esophagogastrostomy. 展开更多
关键词 Gastric cancer Proximal gastrectomy ESOPHAGOGASTROSTOMY Quality of life
下载PDF
Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy 被引量:18
11
作者 Jian Ang Liang Hu +5 位作者 Pin-Tong Huang Jin-Xiu Wu Ling-Na Huang Chun-Hui Cao Yi-Xiong Zheng Li Chen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7026-7032,共7页
AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuv... AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuvant chemotherapy followed by curative resection between September 2011 and February 2012 were analyzed.Pre-operative chemotherapy regimens of fluorouracil + oxaliplatin or S-1 + oxaliplatin were administered in 2-4 cycles over 6-12 wk periods.All patients underwent contrast-enhanced computed tomography(CT) scan and DCUS before and after two courses of pre-operative chemotherapy.The therapeutic response was assessed by CT using the response evaluation criteria in solid tumors(RECIST 1.1) criteria.Tumor area was assessed by DCUS as enhanced appearance of gastric carcinoma due to tumor vascularity during the contrast phase as compared to the normal gastric wall.Histopathologic analysis was carried out according to the Mandard tumor regression grade criteria and used as the reference standard.Receiver operating characteristic(ROC) analysis was used to evaluate the efficacy of DCUS parameters in differentiating histopathological responders from non-responders.RESULTS:The study population consisted of 32 men and 11 women,with mean age of 59.7 ± 11.4 years.Neither age,sex,histologic type,tumor site,T stage,nor N stage was associated with pathological response.The responders had significantly smaller mean tumor size than the non-responders(15.7 ± 7.4 cm vs 33.3 ± 14.1 cm,P < 0.01).According to Mandard's criteria,27 patients were classified as responders,with 11(40.7%) showing decreased tumor size by DCUS.In contrast,only three(18.8%) of the 16 non-responders showed decreased tumor size by DCUS(P < 0.01).The area under the ROC curve was 0.64,with a 95%CI of 0.46-0.81.The effects of several cut-off points on diagnostic parameters were calculated in the ROC curve analysis.By maximizing Youden's index(sensitivity + specificity-1),the best cut-off point for distinguishing responders from non-responders was determined,which had optimal sensitivity of 62.9% and specificity of 56.3%.Using this cut-off point,the positive and negative predictive values of DCUS for distinguishing responders from non-responders were 70.8% and 47.4%,respectively.The overall accuracy of DCUS for therapeutic response assessment was 60.5%,slightly higher than the 53.5% for CT response assessment with RECIST criteria(P = 0.663).Although the advantage was not statistically significant,likely due to the small number of cases assessed.DCUS was able to identify decreased perfusion in responders who showed no morphological change by CT imaging,which can be occluded by such treatment effects as fibrosis and edema.CONCLUSION:DCUS may represent an innovative tool for more accurately predicting histopathological response to neoadjuvant chemotherapy before surgical resection in patients with locally-advanced gastric cancer. 展开更多
关键词 Gastric cancer CHEMOTHERAPY Ultrasonic imaging Predictive value of tests Disease management
下载PDF
滋培汤治疗胃阴不足型慢性萎缩性胃炎临床研究 被引量:11
12
作者 周永添 姚民武 《广州中医药大学学报》 CAS 2022年第5期1027-1032,共6页
【目的】研究滋培汤治疗胃阴不足型慢性萎缩性胃炎的临床疗效。【方法】将64例胃阴不足型慢性萎缩性胃炎患者随机分为治疗组和对照组,每组各32例。对照组给予艾司奥美拉唑肠溶胶囊和铝镁加混悬液口服的西医常规治疗,治疗组在对照组的基... 【目的】研究滋培汤治疗胃阴不足型慢性萎缩性胃炎的临床疗效。【方法】将64例胃阴不足型慢性萎缩性胃炎患者随机分为治疗组和对照组,每组各32例。对照组给予艾司奥美拉唑肠溶胶囊和铝镁加混悬液口服的西医常规治疗,治疗组在对照组的基础上给予滋培汤口服治疗,疗程为2个月。观察2组患者治疗前后中医证候评分、可操作的与胃癌风险联系的胃炎评估(OLGA)分期评分及血清胃蛋白酶原(PG)Ⅰ、PGⅡ及PGⅠ/PGⅡ比值(PGR)的变化情况,并评价2组患者的临床疗效。【结果】(1)疗效方面:治疗2个月后,治疗组的总有效率为93.75%(30/32),对照组为71.88%(23/32),组间比较,治疗组的疗效明显优于对照组(P<0.05)。(2)中医证候评分方面:治疗后,治疗组的胃脘灼痛、饥不欲食、口干、大便干结评分均较治疗前明显改善(P<0.01),而对照组仅胃脘灼痛、饥不欲食评分较治疗前明显改善(P<0.05或P<0.01);组间比较,治疗组对各项证候评分的改善作用均明显优于对照组(P<0.05或P<0.01)。(3)检测指标方面:治疗后,除对照组的PGⅡ外,2组患者的血清PGⅠ、PGⅡ及PGR水平均较治疗前明显改善(P<0.01),且治疗组对血清PGⅠ、PGⅡ及PGR水平的改善作用均明显优于对照组(P<0.01)。(4)OLGA分期评分方面:治疗后,2组患者的OLGA分期评分均较治疗前明显下降(P<0.05或P<0.01),且治疗组对OLGA分期评分的下降作用明显优于对照组(P<0.01)。【结论】在西医常规治疗的基础上联合滋培汤治疗胃阴不足型慢性萎缩性胃炎疗效确切,能有效缓解患者临床症状,延缓甚至逆转慢性萎缩性胃炎的进程。 展开更多
关键词 滋培汤 胃阴不足型 慢性萎缩性胃炎 可操作的与胃癌风险联系的胃炎评估(OLGA)分期评分 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ
下载PDF
Hp感染及胃黏膜TFF1/GKN2表达与慢性胃炎OLGA/OLGIM分期的关系 被引量:6
13
作者 郭殿华 程芃 +2 位作者 陈卿奇 许小康 庞莉 《中华医院感染学杂志》 CAS CSCD 北大核心 2023年第4期527-531,共5页
目的 分析幽门螺杆菌(Hp)感染及胃黏膜三叶草因子1/胃动蛋白2(TFF1/GKN2)表达与慢性胃炎可操作的与胃癌风险联系的胃炎评估/可操作的与胃癌风险联系的肠化生评估(OLGA/OLGIM)分期的关系.方法 收集2020年1月-2021年9月海南西部中心医院... 目的 分析幽门螺杆菌(Hp)感染及胃黏膜三叶草因子1/胃动蛋白2(TFF1/GKN2)表达与慢性胃炎可操作的与胃癌风险联系的胃炎评估/可操作的与胃癌风险联系的肠化生评估(OLGA/OLGIM)分期的关系.方法 收集2020年1月-2021年9月海南西部中心医院收治的156例慢性胃炎患者的临床资料,根据OLGA/OLGIM分期及病变严重程度,将患者分为高分期组(Ⅲ~Ⅳ期组,74例)与低分期组(0~Ⅱ期组,82例),比较两组Hp感染及胃黏膜TFF1、GKN2表达情况,分析高分期组Hp感染与TFF1、GKN2表达的一致性,并记录两组Hp细胞毒素相关基因A(CagA)及TFF1、GKN2表达量,分析OLGA/OLGIM分期与Hp CagA、TFF1、GKN2表达量的相关性;对随访时间≥12个月的Hp感染阳性者作进一步分析,比较其随访期间Hp感染及TFF1、GKN2表达、OLGA/OLGIM分期变化.结果 高分期组Hp感染阳性率高于低分期组(P<0.05),胃黏膜TFF1及GKN2表达阳性率均低于低分期组(P<0.05);高分期组患者Hp感染阳性与胃黏膜TFF1、GKN2表达阴性具有较高一致性,Kappa系数分别为0.774、0.570;高分期组胃黏膜Hp CagA mRNA相对表达量高于低分期组(P<0.05),TFF1及GKN2 mRNA相对表达量均低于低分期组(P<0.05);Spearman秩相关分析显示,OLGA分期及OLGIM分期均与胃黏膜Hp CagA mRNA相对表达量呈正相关(r=0.439、0.425),与TFF1及GKN2 mRNA相对表达量呈负相关(r=-0.712、-0.694、-0.705、-0.687);111例Hp感染阳性者有32例获得12个月的随访,随访12个月时,患者Hp感染阳性率及OLGA分期、OLGIM分期降低(P<0.05),TFF1及GKN2表达阳性率升高(P<0.05).结论 Hp感染可增加慢性胃炎病情进展,该作用机制可能与下调胃黏膜TFF1、GKN2的表达有关,可为慢性胃炎的治疗提供新靶点. 展开更多
关键词 慢性胃炎 幽门螺杆菌 可操作的与胃癌风险联系的胃炎评估/可操作的与胃癌风险联系的肠化生评估 三叶草因子1 胃动蛋白2
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部